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  4. Recombinant Human Kallikrein-15 (KLK15)

Recombinant Human Kallikrein-15 (KLK15)

  • 货号：
    CSB-YP884452HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP884452HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP884452HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP884452HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP884452HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    KLK15
  • Uniprot No.：
  • 别名：
    KLK15; Kallikrein-15; EC 3.4.21.-; ACO protease
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    22-256
  • 氨基酸序列
    LLEGDECAP HSQPWQVALY ERGRFNCGAS LISPHWVLSA AHCQSRFMRV RLGEHNLRKR DGPEQLRTTS RVIPHPRYEA RSHRNDIMLL RLVQPARLNP QVRPAVLPTR CPHPGEACVV SGWGLVSHNE PGTAGSPRSQ VSLPDTLHCA NISIISDTSC DKSYPGRLTN TMVCAGAEGR GAESCEGDSG GPLVCGGILQ GIVSWGDVPC DNTTKPGVYT KVCHYLEWIR ETMKRN
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Protease whose physiological substrate is not yet known.
  • 基因功能参考文献：
    1. KLK15 may be able to cleave many ECM components, similar to several members of the KLK family. Thus the protease could potentially be linked to tumorigenesis by promoting metastasis via this mechanism. PMID: 29928903
    2. Data provide insights into the localization and possible role of KLK15 in human physiology. PMID: 29958881
    3. Pronounced correlations between KLK10/KLK11 (rs = 0.647) and between KLK9/KLK15 (rs = 0.716) mRNA, but not between other combinations, indicate coordinate expression of distinct pairs of peptidases PMID: 29095848
    4. Variations in KLK15, but not KLK11 expression were significantly associated with prognosis in gastric cancer PMID: 26224476
    5. Advanced pathologic stage was associated with significantly higher expression of KLK15 and PCA3 mRNAs. PMID: 23391636
    6. KLK15 mRNA expression levels are a novel marker for the differential diagnosis of prostate cancer. PMID: 23620432
    7. These findings suggest a role for KLK15 genetic variation in the etiology of prostate cancer among men of European ancestry. PMID: 22132073
    8. association with ovarian cancer survival PMID: 21457553
    9. Multivariate analysis identified dichotomised KLK15 expression, corrected for patient parameters age, preoperative prostate-specific antigen level, pathological tumour stage, Gleason score and surgical margins, as an prognostic factor for poor outcome. PMID: 20473923
    10. KLK15 expression analysis could be employed as a valuable tool for the discrimination between benign prostatic hyperplasia and prostate cancer tissue specimens and as an unfavorable prognostic marker for prostate cancer. PMID: 20067463
    11. Data show six non-synonymous amino acid or frame shift changes in the KLK3 gene and three changes in each of the neighboring genes, KLK15 and KLK2. PMID: 19823874
    12. Kallikrein 15 expression is an independent prognostic factors of progression-free and overall survival in breast cancer patients PMID: 12439720
    13. KLK15 expression, as assessed by quantitative RT-PCR, is an independent marker of unfavorable prognosis for ovarian cancer. PMID: 12915603

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Peptidase S1 family, Kallikrein subfamily
  • 组织特异性：
    Highest expression in the thyroid gland. Also expressed in the prostate, salivary, and adrenal glands and in the colon testis and kidney.
  • 数据库链接：

    HGNC: 20453

    OMIM: 610601

    KEGG: hsa:55554

    STRING: 9606.ENSP00000469315

    UniGene: Hs.567535