Your Good Partner in Biology Research

  1. 首页
  2. 蛋白
  3. 重组蛋白
  4. Recombinant Human Keratocan (KERA)

Recombinant Human Keratocan (KERA)

  • 中文名称：
    人KERA重组蛋白
  • 货号：
    CSB-YP012149HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人KERA重组蛋白
  • 货号：
    CSB-EP012149HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人KERA重组蛋白
  • 货号：
    CSB-EP012149HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人KERA重组蛋白
  • 货号：
    CSB-BP012149HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人KERA重组蛋白
  • 货号：
    CSB-MP012149HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    KERA
  • Uniprot No.：
  • 别名：
    CNA2; KERA; KERA_HUMAN; Keratan sulfate proteoglycan keratocan; Keratocan; KTN; SLRR2B
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    21-352
  • 氨基酸序列
    RSVRQVYEVH DSDDWTIHDF ECPMECFCPP SFPTALYCEN RGLKEIPAIP SRIWYLYLQN NLIETIPEKP FENATQLRWI NLNKNKITNY GIEKGALSQL KKLLFLFLED NELEEVPSPL PRSLEQLQLA RNKVSRIPQG TFSNLENLTL LDLQNNKLVD NAFQRDTFKG LKNLMQLNMA KNALRNMPPR LPANTMQLFL DNNSIEGIPE NYFNVIPKVA FLRLNHNKLS DEGLPSRGFD VSSILDLQLS HNQLTKVPRI SAHLQHLHLD HNKIKSVNVS VICPSPSMLP AERDSFSYGP HLRYLRLDGN EIKPPIPMAL MTCFRLLQAV II
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May be important in developing and maintaining corneal transparency and for the structure of the stromal matrix.
  • 基因功能参考文献：
    1. We expand the phenotypic spectrum of biallelic KERA mutations in this report of a boy with juvenile corneal ectasia who was found to harbor an underlying novel homozygous mutation in the gene. PMID: 28799822
    2. KERA mutation c.740A>G has been identified to date in three different populations, which makes it the most frequently occurring mutation in patients with cornea plana PMID: 28677912
    3. The mutation that we report here leads to the deletion of a conserved amino acid (p.Phe125del) from the third LRR motif of the keratocan protein, which might lead to an abnormal tertiary structure of the protein, thereby leading to the disease. PMID: 25967529
    4. a novel KERA variant, p.(Ile225Thr), was detected that segregates with Cornea plana in the homozygous form. PMID: 26099342
    5. Corneal endothelial disorders were found with compound mutations in KERA PMID: 23834557
    6. rare variant in KERA was identified in a large kindred with premature atherosclerosis PMID: 24879339
    7. Linkage and haplotype analyses identified 12q21.33 as a locus for posterior amorphous corneal dystrophy. However, no mutations were identified in the candidate genes (KERA, LUM, DCN, EPYC) within this region. PMID: 20357198
    8. KERA mutation is associated with autosomal recessive cornea plana PMID: 15370545
    9. This is the first report of the identification of a mutation within KERA in a family of Hispanic origin with autosomal recessive cornea plana. PMID: 16157807
    10. No evidence that endothelial dysfunction and germline mutation of lumican and keratocan genes participate in the etiology of subepithelial corneal haze. PMID: 16760896
    11. Specific for mutation in KERA, the ophthalmic phenotype of recessive cornea plana does not significantly vary with different KERA mutations. PMID: 17011957
    12. In addition, no pathogenic sequence variations were found in DCN, DSPG3, LUM, PITX2 and FOXC1, which have also been implicated in corneal and anterior segment dysgenesis. PMID: 17558846
    13. This is the first description of recessive cornea plana in a white British family and it is the second report on the p.N247S change in the KERA gene. PMID: 17679937
    14. Multiple core-protein species were detected for decorin, biglycan, lumican and keratocan in the degenerate osteoarthritic articular cartilage and menisci. PMID: 18620607

    显示更多

    收起更多

  • 相关疾病：
    Cornea plana 2, autosomal recessive (CNA2)
  • 亚细胞定位：
    Secreted, extracellular space, extracellular matrix.
  • 蛋白家族：
    Small leucine-rich proteoglycan (SLRP) family, SLRP class II subfamily
  • 组织特异性：
    Cornea (at protein level). Increased expression in the stroma of keratoconus corneas. Also detected in trachea, and in low levels, in intestine, skeletal muscle, ovary, lung and putamen.
  • 数据库链接：

    HGNC: 6309

    OMIM: 217300

    KEGG: hsa:11081

    STRING: 9606.ENSP00000266719

    UniGene: Hs.125750