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  4. Recombinant Human Killer cell immunoglobulin-like receptor 2DS5 (KIR2DS5), partial

Recombinant Human Killer cell immunoglobulin-like receptor 2DS5 (KIR2DS5), partial

  • 货号：
    CSB-YP619902HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP619902HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP619902HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP619902HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP619902HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    KIR2DS5; CD158G; NKAT9Killer cell immunoglobulin-like receptor 2DS5; CD158 antigen-like family member G; MHC class I NK cell receptor; Natural killer-associated transcript 9; NKAT-9; CD antigen CD158g
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Activating natural killer (NK) receptor that recognizes C2 epitopes of HLA-C alleles. Bridging the innate and adaptive immune systems, NK cells express a number of cell surface receptors which either inhibit or stimulate their cytotoxicity. Able to activate NK cells citotoxicity and cytokine production such as IFNG. Receptor functions are attenuated even lost in some alleles, such as KIR2DS5*002 reprensented in this entry.
  • 基因功能参考文献：
    1. KIR2DS5 gene may be protective against hypertension. PMID: 29105364
    2. The presence ofKIR2DS5 reduced the risk of endometriosis if a female possessed alleles from group C2 of HLA-C. PMID: 25724317
    3. The presence of KIR2DS2/2DL2 with KIR2DS5 abrogated the risk of KIR2DS2/2DL2 and the protective benefit of KIR2DS5. PMID: 24571473
    4. genetic polymorphism impacts glycosylation and protein expression level PMID: 24269691
    5. The activating KIR2DS5 gene was significantly increased in thyroid ancer patients compared to the controls. PMID: 22836040
    6. Data indicate that killer-cell immunoglobulin-like receptors (KIRs)activator (KIR3DS1 and KIR2DS5) and inhibitory (KIR2DL5) genes are associated with severe pandemic influenza A (H1N1) 2009 infections. PMID: 22652695
    7. In summary, KIR polymorphisms may be involved in the development of Epstein-Barr virus associated hemophagocytic lymphohistiocytosis, with KIR2DS5 promoting susceptibility to this disease. PMID: 22376216
    8. increase in the allele distribution in northern province of Tehran compared with that reported for the southern Iran population PMID: 21867738
    9. predisposition to systemic lupus erythematosus was associated with GTGT deletion at the SLC11A1 3'UTR, presence of KIR2DS2 +/KIR2DS5 +/KIR3DS1 + profile, increased number of stimulatory KIR genes and European and Amerindian ancestries PMID: 21233146
    10. The presence of KIR2DS5 gene protects human from endometriosis, ankylosing spondylitis, and acute rejection of kidney graft. PMID: 20865034
    11. reduced allele frequency in African Americans PMID: 19410616
    12. Donor activating KIR2DS5 may improve disease-free survival in non T-cell-depleted haploidentical hematopoietic stem cell transplantation. PMID: 18315912
    13. Positive linkage disequilibrium was seen and between KIR3DS1 and KIR2DS5. PMID: 12559621
    14. Carriage of activating 2ds5 was increased in patient with herpes virus RDs. PMID: 17592337
    15. The most frequent allele found in 132 cell lines from International Workshop samples is KIR2DS5*005, an allele characteristic of African populations. PMID: 18498296
    16. The stimulatory KIR2DS5 gene was associated with improved leukemia free survival. PMID: 18555529
    17. KIR2DS5 gene codes for a surface receptor triggering natural killer cell function. PMID: 18624290
    18. The level of KIR2DS5 surface expression was impacted by residue 47 but that variation at several residues in the D2 domain of KIR2DS5 ultimately had a more profound effect. PMID: 18682925
    19. Lack of activation KIR2DS5 may play an important role in the development of bronchiolitis obliterans but not in the control of cytomegalovirus reactivation after lung transplantation. PMID: 18765192
    20. KIR2DS1 incompatibilities increased risk of relapse after allogeneic hematopoietic stem cell transplantation PMID: 19500138

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  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein; Extracellular side.
  • 蛋白家族：
    Immunoglobulin superfamily
  • 组织特异性：
    Expressed on a discrete subset of peripheral blood NK cells.
  • 数据库链接：

    HGNC: 6337

    OMIM: 604956

    KEGG: hsa:3810

    UniGene: Hs.744266