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  4. Recombinant Human Killer cell lectin-like receptor subfamily F member 2 (KLRF2), partial

Recombinant Human Killer cell lectin-like receptor subfamily F member 2 (KLRF2), partial

  • 中文名称：
    人KLRF2重组蛋白
  • 货号：
    CSB-YP514229HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人KLRF2重组蛋白
  • 货号：
    CSB-EP514229HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人KLRF2重组蛋白
  • 货号：
    CSB-EP514229HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人KLRF2重组蛋白
  • 货号：
    CSB-BP514229HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人KLRF2重组蛋白
  • 货号：
    CSB-MP514229HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    KLRF2
  • Uniprot No.：
  • 别名：
    KLRF2Killer cell lectin-like receptor subfamily F member 2; Lectin-like receptor F2; Activating coreceptor NKp65
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    C-type lectin-like receptor involved in natural killer cell mediated cytotoxicity and cytokine secretion in keratinocytes via its interaction with CLEC2A.
  • 基因功能参考文献：
    1. NKp65 utilizes a hemi-immunoreceptor tyrosine-based activation motif -like motif for cellular activation that requires Syk, although Syk appears not to be recruited to NKp65. PMID: 28082678
    2. Key residues at the membrane-distal surface of KACL, but not glycosylation, determine the functional interaction of the keratinocyte-specific C-type lectin-like receptor KACL with its high-affinity receptor NKp65 PMID: 25510854
    3. structure explains the exceptionally high affinity of the NKp65-KACL interaction compared with other cell-cell interaction pairs, which may compensate for the monomeric nature of NKp65 to achieve cell activation PMID: 23803857
    4. Keratinocytes express KACL and are capable of stimulating NKp65-expressing cells in a KACL-dependent manner. PMID: 20194751
  • 亚细胞定位：
    Cell membrane; Single-pass type II membrane protein.
  • 数据库链接：

    HGNC: 37646

    KEGG: hsa:100431172

    UniGene: Hs.725113