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  4. Recombinant Human Late cornified envelope protein 3A (LCE3A)

Recombinant Human Late cornified envelope protein 3A (LCE3A)

  • 中文名称：
    人LCE3A重组蛋白
  • 货号：
    CSB-EP716360HUb0
  • 规格：
    ￥1536
  • 图片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

产品详情

  • 纯度：
    Greater than 90% as determined by SDS-PAGE.
  • 基因名：
    LCE3A
  • Uniprot No.：
  • 别名：
    LCE3A; LEP13Late cornified envelope protein 3A; Late envelope protein 13
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length
  • 来源：
    E.coli
  • 分子量：
    12.6kDa
  • 表达区域：
    1-89aa
  • 氨基酸序列
    MSCQQNQQQCQPPPKCPAKSPAQCLPPASSSCAPSSGGCGPSSERSCCLSHHRCRRSHRCRCQSSNSCDRGSGQQGGSSSCGHSSAGCC
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Tris-based buffer,50% glycerol
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    A structural component of the cornified envelope of the stratum corneum involved in innate cutaneous host defense (Probable). Possesses defensin-like antimicrobial activity against a broad spectrum of Gram-positive and Gram-negative bacteria, both aerobic and anaerobic species. Upon inflammation, may regulate skin barrier repair by shaping cutaneous microbiota composition and immune response to bacterial antigens.
  • 基因功能参考文献：
    1. genetic polymorphism is associated with psoriasis vulgaris among Mongolians from Inner Mongolia PMID: 29397434
    2. analysis of disease variants at the LCE3 cluster among the psoriasis patients in India PMID: 27048876
    3. Observational study of gene-disease association. (HuGE Navigator) PMID: 19601998
    4. paper describing nomenclature changes and expression in range of tissues and in response to UV PMID: 15854049
  • 蛋白家族：
    LCE family
  • 组织特异性：
    Skin-specific. Expression was readily detected in adult trunk skin, adult arm skin, fetal skin, penal skin, vulva, esophagus and tongue. Not expressed in the cervix, rectum, lung, colon, or placenta.
  • 数据库链接：

    HGNC: 29461

    OMIM: 612613

    KEGG: hsa:353142

    STRING: 9606.ENSP00000335006

    UniGene: Hs.553714