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  4. Recombinant Human Leucine-rich repeat-containing protein 4 (LRRC4), partial

Recombinant Human Leucine-rich repeat-containing protein 4 (LRRC4), partial

  • 中文名称：
    人LRRC4重组蛋白
  • 货号：
    CSB-YP867195HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人LRRC4重组蛋白
  • 货号：
    CSB-EP867195HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人LRRC4重组蛋白
  • 货号：
    CSB-EP867195HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人LRRC4重组蛋白
  • 货号：
    CSB-BP867195HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人LRRC4重组蛋白
  • 货号：
    CSB-MP867195HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    LRRC4
  • Uniprot No.：
  • 别名：
    LRRC4; BAG; NAG14; UNQ554/PRO1111Leucine-rich repeat-containing protein 4; Brain tumor-associated protein BAG; Nasopharyngeal carcinoma-associated gene 14 protein; Netrin-G2 ligand; NGL-2
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Synaptic adhesion protein. Regulates the formation of exitatory synapses through the recruitment of pre-and-postsynaptic proteins. Organize the lamina/pathway-specific differentiation of dendrites. Plays an important role for auditory synaptic responses. Involved in the suppression of glioma.
  • 基因功能参考文献：
    1. Results show a strong negative correlation between the expression of miR-381 and LRRC4 in osteosarcoma (OS) tissues, indicating LRRC4 as a direct target gene of miR-381. PMID: 27612424
    2. Following EGF stimuli, the D domain of LRRC4 anchors ERK1/2 in the cytoplasm and abrogates ERK1/2 activation and nuclear translocation. PMID: 27884160
    3. polymorphisms and haplotypes in the LRRC4 may have a role in pituitary adenoma in a Chinese population PMID: 24563334
    4. Disturbing miR-182 and -381 inhibits BRD7 transcription and glioma growth by directly targeting LRRC4. PMID: 24404152
    5. LRRC4 inhibited the miR-185 pathway function in glioma PMID: 22834685
    6. Potentially, modulation of LRRC4 or STMN1 expression may be useful for design of new therapies for the intervention of glioma PMID: 21809374
    7. As a glioma suppressor, LRRC4 inhibits the endogenous expression of small regulatory microRNA hsa-miR-381 and decreases cell proliferation and tumor growth in cultured glioma cells. PMID: 21435336
    8. LRRC4 may play an important role in maintaining normal function and suppressing tumorigenesis in the central nervous system. PMID: 15967442
    9. LRRC4 gene might be involved in tumor suppression by restraining DNA synthesis and nucleoli organizer regions-associated proteins. PMID: 16188120
    10. these studies represent the first cDNA array analysis of the effects of LRRC4 on the involvement of different neurobiological genes in U251MG glioblastoma cells and provide new insights into the function of LRRC4 in glioma PMID: 16215635
    11. LRRC4 plays a major role in suppressing U251 cell proliferation by regulating the extracellular signal-regulated kinase (ERK)/Akt/NF-kappaBp65, STAT3, and JNK2/c-Jun pathways. PMID: 16723503
    12. LRRC4 may be a negative regulator of the RPTP-zeta receptor, and contribute to suppressing the invasion ability of gliomas cells PMID: 16941076
    13. LRRC4 inhibits glioblastoma cell proliferation, migration, and angiogenesis by downgrading pleiotropic cytokine responses. PMID: 17541939
    14. Methylation-mediated inactivation of LRRC4 is a frequent and glioma-specific event. PMID: 18976507

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  • 亚细胞定位：
    Membrane; Single-pass type I membrane protein. Cell junction, synapse, postsynaptic cell membrane.
  • 组织特异性：
    Specifically expressed in brain.
  • 数据库链接：

    HGNC: 15586

    OMIM: 610486

    KEGG: hsa:64101

    STRING: 9606.ENSP00000249363

    UniGene: Hs.655003