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  4. Recombinant Human Leucine-rich repeats and immunoglobulin-like domains protein 1 (LRIG1), partial

Recombinant Human Leucine-rich repeats and immunoglobulin-like domains protein 1 (LRIG1), partial

  • 中文名称：
    人LRIG1重组蛋白
  • 货号：
    CSB-YP850317HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人LRIG1重组蛋白
  • 货号：
    CSB-EP850317HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人LRIG1重组蛋白
  • 货号：
    CSB-EP850317HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人LRIG1重组蛋白
  • 货号：
    CSB-BP850317HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人LRIG1重组蛋白
  • 货号：
    CSB-MP850317HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    LRIG1
  • Uniprot No.：
  • 别名：
    Leucine rich repeat protein; Leucine rich repeat protein LRIG1; leucine rich repeats and immunoglobulin like domains 1; Leucine-rich repeats and immunoglobulin-like domains protein 1; leucine-rich repeats- and immunoglobulin-like domains-cotnaining protein 1; LIG 1; LIG-1; LIG1; Lrig1; LRIG1_HUMAN; Ortholog of mouse integral membrane glycoprotein LIG 1
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Acts as a feedback negative regulator of signaling by receptor tyrosine kinases, through a mechanism that involves enhancement of receptor ubiquitination and accelerated intracellular degradation.
  • 基因功能参考文献：
    1. MiR-183 overexpression promoted radioresistance of glioblastoma via down-regulating LRIG1 and increasing the activity of EFGR/Akt. PMID: 29793318
    2. LRIG1 is a negative regulator of RET2A and RET2B and is also downregulated in papillary and medullary thyroid carcinoma PMID: 29436694
    3. LRIG1 expression in human GC tissues is inversely correlated with miR-20a and EGFR. PMID: 29450946
    4. Role of LRIG1 in cancer [review] PMID: 27628597
    5. LRIG1 expression may represent a barrier to EMT PMID: 26387542
    6. LRIG1 role in the atrophic epidermis PMID: 28099467
    7. Downregulation of LRIG1 expression in oral verrucous carcinoma tissue is reported. PMID: 27509922
    8. LRIG1, as a negative mediated gene of tumor, can inhibit biological function of PAs via inhibiting PI3K/AKT and Ras/Raf/ERK pathways, and it might be a new target for gene therapy ofPituitary adenomas PMID: 27465333
    9. LRIG1 and Fascin-1 were differently expressed in cancer and normal lung tissue in patients with NSCLC, which could be a biomarker for mediastinal lymph node metastasis in NSCLC patients. PMID: 28230028
    10. Results suggest that the LRIG1could negatively control MRP-1 and the apoptosis to improve the sensitivity of VP16-related chemotherapy. PMID: 27183435
    11. ERa-dependent expression of LRIG1 dampens ErbB3 signaling in luminal breast cancer cells, and by blocking ERa activity with fulvestrant, LRIG1 is decreased thus permitting ErbB3 accumulation, enhanced ErbB3 signaling to cell survival pathways PMID: 26148232
    12. These findings demonstrate that LRIG1 is an independent prognostic factor in patients with non-small cell lung cancer PMID: 25813475
    13. LRIG1 expression was associated with pathological type, differentiation status, and stage of Non-small Cell Lung Cancer. The result showed that LRIG1 was an independent prognostic factor for OS of NSCLC patients. PMID: 26632716
    14. The inhibitory effects of LRIG1 are most likely mediated by suppression of the EGFR/PI3K/AKT pathway and epithelial-mesenchymal transition (EMT) process. PMID: 25860915
    15. LRIG1 can enhance chemosensitivity in glioblastoma by inhibition of BCL-2 and MnSOD PMID: 25449296
    16. Results showed that leucine-rich repeats and immunoglobulin-like domains can reverse multidrug resistance in glioblastoma, by negatively regulating epidermal growth factor receptor. PMID: 25801120
    17. MiR-20a mediated temozolomide-resistance in glioblastoma cells through negatively regulating LRIG1 expression. PMID: 25960225
    18. Based on these results, we concluded that the upregulation of LRIG1 expression inhibited the EGFR signaling pathway, activated the mitochondrial pathway of apoptosis and eventually increased the sensitivity of bladder cancer cells to CDDP. PMID: 25695283
    19. a subset of human duodenal tumors exhibited features of LRIG1(-/-) adenomas, including loss of LRIG1, gastric metaplasia (MUCIN5AC and MUCIN6), and increased amphiregulin and Egfr activity. PMID: 25794708
    20. LRIG1 is frequently methylated in human CRC and consequent mRNA and protein downregulation may contribute to tumor growth by activating EGFR/AKT signaling PMID: 26159916
    21. findings indicate that downregulation of LRIG1 is possibly a novel potential marker of transformation and tumorigenesis in OSSN cases. PMID: 24709893
    22. LRIG1 evolved in bladder cancer as a rare feedback negative attenuator of EGFR. PMID: 24314030
    23. These findings suggested that LRIG1-targeting siRNA can exert a dramatically inhibitory effect on RNA transcription and protein expression of LRIG1. PMID: 22528225
    24. Loss of LRIG1 was independently associated with risk of any relapse. PMID: 24879564
    25. USP8 is involved in deubiquitination of LRIG1, influencing the efficiency of Met degradation. PMID: 24828152
    26. LRIG1 immunoreactivity could be a clinically important prognostic marker in HPV-associated oropharyngeal cancer. PMID: 24548859
    27. LRIG1 downregulation in cancer cells enhances EGFR-MAPK-SPHK1 signaling and ECM remodeling activity, leading to malignant phenotypes of head and neck cancers PMID: 23624915
    28. LRIG1 mediates degradation of Met by SAIT301 and this degradation does not require Met activation. PMID: 23208509
    29. Downregulation of LRIG1 expression promotes the aggressive properties of glioma cells via EGFR/Akt/c-Myc activation. PMID: 23124613
    30. Data indicate that Lrig3 opposes Lrig1 negative regulatory action and enhances ErbB receptors ERBB2, ERBB3 and ERBB4 stability. PMID: 23723069
    31. LRIG1 inhibits EGFR expression and the downstream signaling activation, interferes with Bcl-2/Topo-2 expressions and eventually sensitizes glioma cells to TMZ PMID: 23850692
    32. High LRIG1 expression is associated with cervical adenocarcinoma progression. PMID: 23165628
    33. These findings suggest that upregulation of LRIG1 expression enhances the CDDP sensitivity in the glioma cell line U251. PMID: 23581227
    34. LRIG1 Loss of heterozygosity (LOH) is frequent across cancers and its loss is an early event in the development of human squamous carcinomas. PMID: 23208928
    35. This study revealed that the previously described up-regulation of EGFR and down-regulation of ERBB4 occurred in all analyzed renal cell carcinoma types, whereas down-regulation of ERBB2 and LRIG1 was only present in clear cell renal cell carcinoma. PMID: 22554477
    36. Cytoplasmic expression of LRIG1 is associated with meningiomas. PMID: 22484910
    37. Observations suggest the tumor suppressor function of LRIG1 is lost in a subset of colorectal cancers. PMID: 22464327
    38. our findings show that both upregulation of RTK signaling and attenuated TNFalpha expression caused by LRIG1 downregulation confers resistance to Smac mimetics PMID: 22241084
    39. ErbB2 activation antagonizes ERalpha-driven Lrig1 expression, providing a mechanistic explanation for Lrig1 loss in ErbB2-positive breast cancer. This work provides strong evidence for a growth-inhibitory role for Lrig1 in breast cancer. PMID: 21821674
    40. LRIG1 and LRIG2 expressions were seen in precancerous cervical epithelium and found to increase with increasing grade. PMID: 21632100
    41. LRIG1-transduced cells treated with cisplatin had more severe DNA damage, cellular apoptosis, growth inhibition and reversal of invasion PMID: 21431282
    42. LRIG1 was a marker for good prognosis after prostatectomy, which might be due to its growth inhibiting properties PMID: 21128282
    43. the LRIG1 ectodomain can be proteolytically shed and can function as a non-cell-autonomous regulator of growth factor signaling PMID: 21087604
    44. ERBB2 and LRIG1 copy number is increased in breast cancer PMID: 19490591
    45. Down-regulation of LIG-1 is associated with cancer PMID: 12234026
    46. Results demonstrate that LRIG1 is an integral cell-surface membrane protein that is expressed by specific cells in various human tissues and that its 143-kDa form might be cleaved into 111-kDa and 32-kDa fragments. PMID: 12684867
    47. downregulation of LRIG1 is associated with renal cell carcinoma PMID: 14520461
    48. LRIG1 evolved in mammals as a feedback negative attenuator of signaling by receptor tyrosine kinases PMID: 15282549
    49. LRIG1-mediated receptor ubiquitination and degradation may contribute to the suppression of ErbB receptor function PMID: 15345710
    50. A breast cancer linked gene is located within an amplicon containing the LRIG1 locus at 3p14.3. PMID: 16168117

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  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein.
  • 组织特异性：
    Widely expressed.
  • 数据库链接：

    HGNC: 17360

    OMIM: 608868

    KEGG: hsa:26018

    STRING: 9606.ENSP00000273261

    UniGene: Hs.518055