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  4. Recombinant Human Leukocyte-associated immunoglobulin-like receptor 1 (LAIR1), partial

Recombinant Human Leukocyte-associated immunoglobulin-like receptor 1 (LAIR1), partial

  • 货号：
    CSB-YP012721HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP012721HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP012721HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP012721HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP012721HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    5133400O11Rik ; CD305; D7Bwg0421e; hLAIR1; LAIR 1; LAIR-1; LAIR1; LAIR1 protein; LAIR1_HUMAN; Leukocyte associated Ig like receptor 1; Leukocyte associated immunoglobulin like receptor 1; Leukocyte-associated immunoglobulin-like receptor 1
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation. May also play its inhibitory role independently of SH2-containing phosphatases. Modulates cytokine production in CD4+ T-cells, down-regulating IL2 and IFNG production while inducing secretion of transforming growth factor beta. Down-regulates also IgG and IgE production in B-cells as well as IL8, IL10 and TNF secretion. Inhibits proliferation and induces apoptosis in myeloid leukemia cell lines as well as prevents nuclear translocation of NF-kappa-B p65 subunit/RELA and phosphorylation of I-kappa-B alpha/CHUK in these cells. Inhibits the differentiation of peripheral blood precursors towards dendritic cells.
  • 基因功能参考文献：
    1. These findings demonstrate that C1q and it's globular region interact with CD33 to activate its inhibitory motifs, while the collagen-like region does not. Whole C1q is required to crosslink CD33 and LAIR-1 and concurrently activate CD33/LAIR-1 inhibitory motifs. PMID: 28325905
    2. Human decidua mesenchymal stem cells may modulate the function of decidual natural killer cells via the interaction between collagen and LAIR1. PMID: 28677766
    3. results suggest that P. falciparum has acquired multiple RIFINs to evade the host immune system by targeting immune inhibitory receptors, as LAIR1 and LILRB1 PMID: 29186116
    4. LAIR1 is used for immune evasion of Plasmodium falciparum by associating with RIFIN. PMID: 29186116
    5. We suggest that LAIR1 and LAIR2 genetic variants are associated with regulation of gene expression and variable pemphigus foliaceus susceptibility, and show indirect association of LAIR2 differential mRNA expression with pemphigus foliaceus pathogenesis. PMID: 26721477
    6. A LAIR1 insertion generates broadly reactive antibodies against malaria variant antigens;findings illustrate, with a biologically relevant example, a novel mechanism of antibody diversification by interchromosomal DNA transposition PMID: 26700814
    7. C1q-mediated repression of human monocytes is regulated by LAIR-1 PMID: 25247291
    8. The LAIR1-SHP-1-CAMK1-CREB pathway sustains the survival and self-renewal of AML stem cells. PMID: 25915125
    9. These data suggest that LAIR-1 has a relevant impact on EOC progression and may be helpful for a better understanding of molecular pathogenesis of cancer. PMID: 25660999
    10. LAIR1 expression is a reliable and inexpensive marker capable of independently predicting time to first treatment in newly diagnosed unselected patients with chronic lymphocytic leukemia. PMID: 24415628
    11. The expression of LAIR -1 on pDCs of juvenile systemic lupus erythematosus patients was significantly lower than that of control patients. PMID: 24399813
    12. a novel pathway for the immunomodulatory functions of SP-D mediated via binding of its collagenous domains to LAIR-1. PMID: 24585933
    13. positive association between concentrations of amniotic fluid sLAIR-1 and neonatal lung compliance PMID: 24386309
    14. LAIR-1 may play an important role in immune imbalance in children with immune thrombocytopenia. PMID: 24750832
    15. Studies indicate that Megakaryocyte maturation is accompanied by up-regulation of glycoprotein VI and down-regulation of leukocyte-associated immunoglobulin-like receptor-1. PMID: 20713462
    16. differential role in T-cells and macrophages in patients with rheumatoid arthritis PMID: 24380839
    17. C1q is a functional ligand for LAIR-1 restricting immune cell differentiation and activation. PMID: 23093673
    18. Loss of LAIR-1 function is associated with systemic lupus erythematosus PMID: 22355402
    19. tumor-expressed collagens can bind and trigger immune inhibitory signaling via LAIR-1, suggesting that collagens indeed may affect tumor immune evasion. PMID: 21955987
    20. Data show that pDCs isolated from peripheral blood of systemic lupus erithematosus (SLE) patients express lower levels of LAIR-1 while displaying slight but consistent expression of NKp44. PMID: 21151495
    21. These results suggest that LAIR-1 is a likely candidate for an early marker of megakaryocytes differentiation, and provide initial evidence indicating that LAIR-1 serves as a negative regulator of megakaryocytopoiesis. PMID: 21216234
    22. The expression of LAIR-1 is up-regulated in tumor patients, which may contribute to cancer immune escape. PMID: 18394348
    23. unanticipated mechanism of collagen recognition common to LAIR-1 and GPVI PMID: 20007810
    24. LAIR-1 exerts inhibitory functions on antigen-specific effector T cells PMID: 12072189
    25. NK cells derived from a boy with CAEBV showed decreased cytotoxic function and impaired IFN-gamma secretion. In addition, the NK cells lacked expression of the broadly expressed NK receptor, LAIR-1. PMID: 12757266
    26. structure and role of LAIR (review) PMID: 15065762
    27. Collagens are functional ligands for LAIR-1 and directly inhibit immune cell activation in vitro. PMID: 16754721
    28. Regulated expression of LAIR-1 and the subsequent change in the threshold for activation may be a mechanism to modulate inhibition of the immune system. PMID: 17330824
    29. in cell lines, LAIR-1, which is not expressed on platelets but is present on most hematopoietic cells, inhibits GPVI responses to collagen but not convulxin PMID: 17764536
    30. A receptor that potentially is able to regulate multiple steps of an immune response.[REVIEW] PMID: 18063695
    31. LAIR-2 prevents binding of human LAIR-1 to collagens and LAIR-1 cross-linking in vitro, suggesting that the protein has an immunoregulatory function in vivo. PMID: 18209062
    32. both constitutive and sIgM-induced phosphorylation of p38 and JNK is inhibited by LAIR-1 through an ITIM-dependent signal; this inhibitory signal is missing when LAIR-1 is not expressed as occurs in HR CLL. PMID: 18288129
    33. Human collagen II peptides II-17, -30 and -56 and collagen III peptides III-1, -30, -38, -44, -45, and -51 specifically interacted with hLAIR-1 expressed on K562 cells. PMID: 19345263
    34. Mutation of a single residue, arginine 65, dramatically decreases the binding of LAIR-1 to collagens. PMID: 19380792

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  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein.
  • 组织特异性：
    Expressed on the majority of peripheral mononuclear cells, including natural killer (NK) cells, T-cells, B-cells, monocytes, and dendritic cells. Highly expressed in naive T-cells and B-cells but no expression on germinal center B-cells. Abnormally low ex
  • 数据库链接：

    HGNC: 6477

    OMIM: 602992

    KEGG: hsa:3903

    STRING: 9606.ENSP00000375622

    UniGene: Hs.572535