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  4. Recombinant Human Lithostathine-1-alpha (REG1A)

Recombinant Human Lithostathine-1-alpha (REG1A)

  • 货号：
    CSB-YP019546HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP019546HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP019546HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP019546HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP019546HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    REG1A
  • Uniprot No.：
  • 别名：
    ICRF; Islet cells regeneration factor; Islet of Langerhans regenerating protein; Lithostathine 1 alpha ; Lithostathine 1 alpha precursor; Lithostathine; Lithostathine-1-alpha; MGC12447 ; P19 ; Pancreatic stone protein; Pancreatic stone protein secretory; Pancreatic thread protein; Protein X; PSP; PSPS ; PSPS1 ; PTP; RATRGPI; REG; REG-1-alpha; Reg1; REG1A; REG1A_HUMAN; Regenerating islet derived 1 alpha; Regenerating islet derived 1 alpha pancreatic stone protein pancreatic thread protein; Regenerating islet-derived protein 1-alpha; Regenerating protein I alpha
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    23-166
  • 氨基酸序列
    QEAQTELP QARISCPEGT NAYRSYCYYF NEDRETWVDA DLYCQNMNSG NLVSVLTQAE GAFVASLIKE SGTDDFNVWI GLHDPKKNRR WHWSSGSLVS YKSWGIGAPS SVNPGYCVSL TSSTGFQKWK DVPCEDKFSF VCKFKN
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Might act as an inhibitor of spontaneous calcium carbonate precipitation. May be associated with neuronal sprouting in brain, and with brain and pancreas regeneration.
  • 基因功能参考文献：
    1. Serum levels of PCT and PSP are promising biomarkers for early diagnosis of pediatric acute osteomyelitis. PMID: 29091592
    2. PSP/reg levels are significantly up-regulated in diabetic kidney disease patients and might be related to renal injury PMID: 28418911
    3. Both univariate and multivariate analysis demonstrated that REG1A expression was associated with OS and PFS, and conducted harmful effects on nasopharyngeal carcinoma progression and survival. This study suggested that REG1A expression could serve as an independent adverse factor for survival in nasopharyngeal carcinoma. PMID: 29162157
    4. Reg I may play a role in the maintenance of mucosal barrier function by inducing tight junction proteins such as claudins 3 and 4. PMID: 27055226
    5. the prognostic value of procalcitonin (PCT), high-sensitivity C-reactive protein (hs-CRP), and pancreatic stone protein (PSP) in children with sepsis, was investigated. PMID: 28358790
    6. REG1alpha was overexpressed in bladder cancer tissues compared with adjacent normal samples. Downregulation of REG1alpha expression in urothelial bladder cancer can reduce tumor growth, migration, invasion and angiogenesis. PMID: 28209239
    7. REG-I is expressed in head and neck squamous cell carcinoma and is associated with a longer survival status. PMID: 27539087
    8. We have established a novel, three-protein biomarker panel that is able to detect patients with early-stage pancreatic cancer in urine specimens:LYVE-1, REG1A, and TFF1 were selected as candidate biomarkers PMID: 26240291
    9. post-operative serum PSP levels were significantly associated with the presence of infection in both the on-pump and off-pump setting. PMID: 25793700
    10. REG Ialpha protein may play a role in angiogenesis during progression of gastric cancer PMID: 25813126
    11. PSP/reg is significantly up-regulated in T2DM patients, and PSP/reg levels are related to the duration of diabetes. PMID: 25234740
    12. the expression of REG Ialpha and REG Ibeta may be upregulated in human beta cells under inflammatory conditions through the JAK/STAT pathway PMID: 25767811
    13. Collectively, these findings suggest that REG Ialpha activates c-Jun via the JNK and ERK pathway, thereby enhancing radiosensitivity PMID: 25656613
    14. Pancreactic stone protein levels were able to diagnose sepsis in patients admitted to intensive care units. PMID: 23531337
    15. PSP/reg levels were significantly higher in patients with a PELOD score of 12 or higher or in those with multiple organ dysfunction syndrome. Patients who died tended to have higher PSP/reg levels. PMID: 24594294
    16. REG Ialpha overexpression is a characteristic ofsessile serrated adenoma/polyps of the colon, which appears to reflect aberration of crypt cell compartmentalization. PMID: 24225137
    17. The effects of REG IA on AD and SCC cells were different in the in vitro study, and a correlation between REG IA expression and patient prognosis was noted in the in vivo study PMID: 24065141
    18. Reduced REG1A expression is associated with chemosensitivity in advanced thoracic esophageal squamous cell carcinoma. PMID: 23645481
    19. PSP/reg and CRP are differentially regulated by HNF1A and HNF4A in maturity-onset diabetes of the young PMID: 23803251
    20. Immunohistochemistry against known cell-type markers on serial sections has localised the expression of REGs to metaplastic Paneth cells (REG1A, REG1B and REG3A) and enteroendocrine cells (REG4), with a marked expansion of expression during inflammation. PMID: 23519454
    21. Reg family proteins stimulate pancreatic beta cell proliferation. PMID: 24055447
    22. Autoimmunity to REG Ialpha might play a role in the degeneration of minor salivary gland ductal epithelial cells in primary Sjogren's syndrome. PMID: 23701206
    23. Regenerating gene (REG) 1 alpha promotes pannus progression in patients with rheumatoid arthritis. PMID: 22203215
    24. REG 1A and REG 1B were upregulated during amebiasis and may function to protect the intestinal epithelium from parasite-induced apoptosis. PMID: 21586335
    25. Regenerating islet-derived 1alpha (Reg-1alpha) protein is new neuronal secreted factor that stimulates neurite outgrowth via exostosin Tumor-like 3 (EXTL3) receptor. PMID: 22158612
    26. Regenerating I protein was highly expressed in pure seminoma and in placental-like alkaline phosphatase-positive seminiferous tubules with in situ carcinoma. PMID: 21683984
    27. found a significant increase in REG Ialpha in the sera of celiac disease patients when compared with controls PMID: 21867979
    28. ELISA showed that the serum level of REG1alpha was significantly higher in patients with pancreatic cancer than it was in the normal controls. PMID: 21691750
    29. Raised serum Reg1alpha protein in type 1 and type 2 diabetes and anti-Reg1alpha antibodies in type 1 diabetes, are reported. PMID: 20972946
    30. Upregulation of REG Ialpha accelerates tumor progression in pancreatic cancer with diabetes. PMID: 20099282
    31. REG Ialpha protein may have a pathophysiological role as a biological mediator for immune cell-derived IL-22 in the ulcerative colitis mucosa. PMID: 20065946
    32. This finding suggests that REG I may act through IL-6 to exert effects on squamous esophageal cancer cell biology. PMID: 20056108
    33. did not find any association between abnormalities of either reg1 alpha or reg1 beta gene with type 1 diabetes mellitus, fibrocalculous pancreatopathy, or type 2 diabetes mellitus PMID: 11796176
    34. Characterization, structural analysis and putative functions. Review. PMID: 12369899
    35. REG expression was reported to be an independent predictor of overall gastric adenocarcinoma patient survival PMID: 15022278
    36. Reg I alpha protein may play a role in the development of gastric cancers PMID: 15166487
    37. Reg I was observed not only in pancreatic acinar cells but also in the duct-like cells and dilated duct cells. Reg I expression was linked to acinar cell dedifferentiation. PMID: 15211106
    38. Analysis of the protein in the bile of patients with pancreaticobiliary maljunction/ choledochal cysts PMID: 15628732
    39. REG Ialpha gene is inducible by cytokine stimulation and its gene product may function as a mitogenic and/or an antiapoptotic factor in the development of early gastric cancer. PMID: 15765400
    40. Damaged heart may be a target for Reg action, and Reg may protect against acute heart stress. PMID: 15778284
    41. Polymorphisms in reg1alpha gene, including the regulatory variants singly or in combination with the known mutations in SPINK1 and/or CTSB genes, are not associated with tropical calcific pancreatitis. PMID: 17990360
    42. REG Ialpha protein mediated the anti-apoptotic effects of STAT3 signaling in gastric cancer cells by enhancing Akt activation, Bad phosphorylation and Bcl-xL expression PMID: 18024479
    43. in patients treated with chemoradiotherapy, 8 of 23 REG I-positive patients showed complete responses to chemoradiotherapy; only 1 of 19 REG I-negatives did so; survival rate among REG I-positive patients was significantly better than REG I-negatives PMID: 18259819
    44. REG expression in Barrett's esophagus. Expression of REG Ialpha was more frequently observed in patients who showed squamous re-epithelialization of Barrett's esophagus at biopsy sites. PMID: 18289358
    45. REG1A is prognostic molecular marker associated with peritoneal carcinomatosis in colorectal cancer and is significantly raised in peritumoral normal tissue compared to mucosa from healthy individuals, suggesting a molecular field effect of secreted REG1A PMID: 18452172
    46. The expression of the REG1A gene is closely related to the infiltrating property of primary gastric carcinoma. PMID: 18630596
    47. Overexpression of REG1A is associated with breast cancer. PMID: 18781363
    48. REG1A enhances chemo- and radiosensitivity in squamous cell esophageal cancer cells. PMID: 19032369
    49. Expression of REG Ialpha but not REG IV was an independent predictor of poor outcome in patients with gastric cancer. PMID: 19329938
    50. The expression of REG gene is closely related to the carcinoma invasiveness of gastric neoplasms. PMID: 14508825

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  • 亚细胞定位：
    Secreted.
  • 组织特异性：
    In pancreatic acinar cells and, in lower levels, in brain. Enhanced expression of PSP-related transcripts and intraneuronal accumulation of PSP-like proteins is found in brain from Alzheimer disease and Down syndrome patients.
  • 数据库链接：

    HGNC: 9951

    OMIM: 167770

    KEGG: hsa:5967

    STRING: 9606.ENSP00000233735

    UniGene: Hs.4158