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  4. Recombinant Human Low-density lipoprotein receptor-related protein 12 (LRP12), partial

Recombinant Human Low-density lipoprotein receptor-related protein 12 (LRP12), partial

  • 中文名称：
    人LRP12重组蛋白
  • 货号：
    CSB-YP896728HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人LRP12重组蛋白
  • 货号：
    CSB-EP896728HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人LRP12重组蛋白
  • 货号：
    CSB-EP896728HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人LRP12重组蛋白
  • 货号：
    CSB-BP896728HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人LRP12重组蛋白
  • 货号：
    CSB-MP896728HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    LRP12
  • Uniprot No.：
  • 别名：
    AI848829; FLJ12929; Low density lipoprotein receptor related protein 12; Low-density lipoprotein receptor-related protein 12; LRP 12; LRP-12; LRP12; LRP12_HUMAN; ST7; Suppressor of tumorigenicity 7 protein
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Probable receptor, which may be involved in the internalization of lipophilic molecules and/or signal transduction. May act as a tumor suppressor.
  • 基因功能参考文献：
    1. LRP12 DNA methylation as a powerful predictive marker for carboplatin resistance. PMID: 30029672
    2. Accumulation of functional promoter-associated allelic variants with impact on the transcriptional regulation of LRP12 provides a new pathomechanism for GGs, i.e. highly differentiated epileptogenic brain tumors PMID: 27142828
    3. Results indicate that low-density lipoprotein receptor-related protein 12 silencing during brain development results in cortical dyslamination and seizure sensitization. PMID: 26639854
    4. As the preplate separates, Lrp12/Mig13a-positive neurons polarize in the radial plane and form a pseudocolumnar pattern, prior to moving to a deeper position within the emerging subplate layer. PMID: 20439316
    5. ST7 is a novel low-density lipoprotein receptor-related protein (LRP) with a cytoplasmic tail that interacts with proteins related to signal transduction pathways. PMID: 12809483

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  • 亚细胞定位：
    Membrane; Single-pass type I membrane protein. Membrane, coated pit.
  • 蛋白家族：
    LDLR family
  • 组织特异性：
    Widely expressed in heart, skeletal muscle, brain, lung, placenta and pancreas, but not in tissues consisting of a large number of epithelial cells, such as liver and kidney. Expressed at very low levels in a number of tumor-derived cell lines.
  • 数据库链接：

    HGNC: 31708

    KEGG: hsa:29967

    STRING: 9606.ENSP00000276654

    UniGene: Hs.600630