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  4. Recombinant Human Lymphocyte antigen 86 (LY86)

Recombinant Human Lymphocyte antigen 86 (LY86)

  • 货号：
    CSB-YP013252HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP013252HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP013252HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP013252HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    LY86
  • Uniprot No.：
  • 别名：
    BPAD; dJ80N2.1; Ly 86; Ly-86; Ly86; LY86_HUMAN; Lymphocyte antigen 86; Lymphocyte antigen 86 precursor; Major affective disorder 1; MD 1; MD-1; MD1 protein; MD1 RP105 associated ; MMD 1; MMD-1; Protein MD 1; Protein MD-1; RP1-80N2.1
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    21-162
  • 氨基酸序列
    GGGGKAWPTH VVCSDSGLEV LYQSCDPLQD FGFSVEKCSK QLKSNINIRF GIILREDIKE LFLDLALMSQ GSSVLNFSYP ICEAALPKFS FCGRRKGEQI YYAGPVNNPE FTIPQGEYQV LLELYTEKRS TVACANATIM CS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May cooperate with CD180 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) and cytokine production. Important for efficient CD180 cell surface expression.
  • 基因功能参考文献：
    1. our results reveal that MD-1 deficiency is of critical importance in down-regulating induction and progression of colitis, thereby suggesting that MD-1 might be a target for future interventional therapies of inflammatory bowel disease. PMID: 27209086
    2. DNA methylation of the LY86 gene is associated with obesity, insulin resistance, and inflammation. PMID: 24735745
    3. MD-1 may be a disease susceptibility gene for adult asthma in a Southern Han population in China. PMID: 21426727
    4. Both mouse and human RP105/MD-1 exhibit dimerization of the 1:1 RP105/MD-1 complex, demonstrating a novel organization. PMID: 21959264
    5. In this study, we produced variants of MD-1 and MD-2 in Pichia pastoris. Contrary to previous reports, this study suggests that MD-1 can bind to LPS. PMID: 21130168
    6. in the promoter region we identified 3 SNPs, rs1334710, rs4959389 and rs977785 that are associated with mite-sensitive allergy in Taiwanese children; results suggested that MD-1 could be a susceptible gene for mite-sensitive allergy in Taiwanese children PMID: 18001295
    7. Identified MD-1 SNP (rs7740529) association with asthma in Taiwanese children and adults. PMID: 19255686

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  • 亚细胞定位：
    Secreted, extracellular space. Note=Associated with CD180 at the cell surface.
  • 组织特异性：
    Highly expressed in B-cells, monocytes and tonsil.
  • 数据库链接：

    HGNC: 16837

    OMIM: 605241

    KEGG: hsa:9450

    STRING: 9606.ENSP00000230568

    UniGene: Hs.653138