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  4. Recombinant Human Lymphocyte-specific protein 1 (LSP1)

Recombinant Human Lymphocyte-specific protein 1 (LSP1)

  • 中文名称：
    人LSP1重组蛋白
  • 货号：
    CSB-EP013214HU
  • 规格：
    ￥1344
  • 图片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
    • Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP013214HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) LSP1.
    • Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP013214HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) LSP1.
  • 其他：

产品详情

  • 纯度：
    Greater than 90% as determined by SDS-PAGE.
  • 基因名：
    LSP1
  • Uniprot No.：
  • 别名：
    47 kDa actin binding protein; 47 kDa actin-binding protein; 52 kDa phosphoprotein; F actin binding and cytoskeleton associated protein; Leufactin (leukocyte F-actin binding protein); Leufactin; Leukocyte F actin binding protein; Leukocyte specific protein 1; LSP 1; Lsp1; LSP1_HUMAN; Lymphocyte specific antigen WP34; Lymphocyte specific protein 1; Lymphocyte specific protein pp52; Lymphocyte-specific antigen WP34; Lymphocyte-specific protein 1; OTTHUMP00000014138; OTTHUMP00000014139; OTTHUMP00000014140; OTTHUMP00000069612; OTTHUMP00000069614; OTTHUMP00000069615; OTTHUMP00000069616; pp52; Protein pp52; S37 protein; WP 34; WP34
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of BC001785
  • 来源：
    E.coli
  • 分子量：
    64.2kDa
  • 表达区域：
    1-339aa
  • 氨基酸序列
    MAEASSDPGAEEREELLGPTAQWSVEDEEEAVHEQCQHERDRQLQAQDEEGGGHVPERPKQEMLLSLKPSEAPELDEDEGFGDWSQRPEQRQQHEGAQGTLDSGEPPQCRSPEGEQEDRPGLHAYEKEDSDEVHLEELSLSKEGPGPEDTVQDNLGAAGAEEEQEEHQKCQQPRTPSPLVLEGTIEQSSPPLSPTTKLIDRTESLNRSIEKSNSVKKSQPDLPISKIDQWLEQYTQAIETAGRTPKLARQASIELPSMAVASTKSRWETGEVQAQSAAKTPSCKDIVAGDMSKKSLWEQKGGSKTSSTIKSTPSGKRYKFVATGHGKYEKVLVEGGPAP
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal GST-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Tris-based buffer,50% glycerol
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May play a role in mediating neutrophil activation and chemotaxis.
  • 基因功能参考文献：
    1. LSP1 rs3817198 T > C polymorphism is associated with increased risk of breast cancer, especially in Caucasian and Asian populations [meta-analysis] PMID: 27590509
    2. These results show that LSP1 is critical regulator of actomyosin contractility in primary macrophages. PMID: 29410425
    3. Underexpression of LSP1 is associated with Breast Cancer Recurrence. PMID: 27165221
    4. LSP1 rs569550 and rs592373 polymorphisms are both risk factors for breast cancer. PMID: 26191300
    5. the importance of LSP1 Copy number variations and LSP1 insufficiency in the pathogenesis of rheumatoid arthritis, is reported. PMID: 26554018
    6. The breast cancer SNP LSP1 rs3817198 was associated with an increased risk of lung cancer (odds ratio: 1.10) This association was strongest for women with adenocarcinoma (P = 1.2x10(-4)). PMID: 24681604
    7. Data indicate that slit2N alters the localization and binding of Robo1 to WASp and LSP1 in HIV-1-gp120-treated immature dendritic cells (iDCs). PMID: 23119100
    8. Single nucleotide polymorphism in LSP1 is associated with breast cancer. PMID: 22454379
    9. The LSP1 rs3817198T>C polymorphism is a low-penetrant risk factor for developing breast cancer but may not be in Africans. PMID: 21127985
    10. Low-risk variants of LSP1 is associated with familial breast cancer. PMID: 19856316
    11. The LSP1 and 2q35 SNPs appear to interact multiplicatively on breast cancer risk for BRCA2 mutation carriers. PMID: 19656774
    12. LSP1 interacts with F-actin and the cytoskeleton through residues downstream of amino acid residue 230. The cytoskeleton binding site of mouse LSP1 maps to the 300-330 interval. PMID: 12972289
    13. Leukocyte-specific protein 1 is a cytoskeletal targeting protein for the ERK/MAP kinase pathway PMID: 15090600
    14. LSP1 protein facilitates virus transport into the proteasome after its interaction with DC-SIGN through its interaction with cytoskeletal proteins. PMID: 17296787
    15. MK2-regulated LSP1 phosphorylation is involved in stabilization of F-actin polarization during neutrophil chemotaxis. PMID: 17481585
    16. DC-SIGN was constitutively associated with a signalosome complex consisting of the scaffold proteins LSP1, KSR1 and CNK and the kinase Raf-1 PMID: 19718030

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  • 亚细胞定位：
    Cell membrane; Peripheral membrane protein; Cytoplasmic side.
  • 组织特异性：
    Activated T-lymphocytes.
  • 数据库链接：

    HGNC: 6707

    OMIM: 153432

    KEGG: hsa:4046

    STRING: 9606.ENSP00000308383

    UniGene: Hs.56729