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  4. Recombinant Human Lysophosphatidylcholine acyltransferase 1 (LPCAT1), partial

Recombinant Human Lysophosphatidylcholine acyltransferase 1 (LPCAT1), partial

  • 货号：
    CSB-YP013052HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP013052HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP013052HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP013052HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP013052HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    LPCAT1
  • Uniprot No.：
  • 别名：
    1 acylglycerophosphocholine O acyltransferase; 1 alkylglycerophosphocholine O acetyltransferase; 1-acylglycerophosphocholine O-acyltransferase; 1-alkylglycerophosphocholine O-acetyltransferase; Acetyl CoA:lyso PAF acetyltransferase; Acetyl CoA:lyso platelet activating factor acetyltransferase; Acetyl-CoA:lyso-PAF acetyltransferase; Acetyl-CoA:lyso-platelet-activating factor acetyltransferase; Acyl CoA:lysophosphatidylcholine acyltransferase 1; Acyltransferase like 2; Acyltransferase-like 2; AGPAT10; AGPAT9; AYTL1; AYTL2; FLJ12443; FLJ41609; LPC acyltransferase 1; LPC acyltransferase; lpcat; LPCAT-1; LPCAT1; Lyso PAF acetyltransferase; Lyso-PAF acetyltransferase; LysoPAFAT; LysoPC acyltransferase 1; Lysophosphatidylcholine acyltransferase 1; PCAT1_HUMAN; PFAAP3; Phosphonoformate immuno associated protein 3; Phosphonoformate immuno-associated protein 3
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Exhibits acyltransferase activity. Exhibits acetyltransferase activity. Activity is calcium-independent. Catalyzes the conversion of lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) into phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC). Catalyzes the conversion 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone. Displays a clear preference for saturated fatty acyl-CoAs, and 1-myristoyl or 1-palmitoyl LPC as acyl donors and acceptors, respectively. Involved in platelet-activating factor (PAF) biosynthesis by catalyzing the conversion of the PAF precursor, 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) into 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (PAF). May synthesize phosphatidylcholine in pulmonary surfactant, thereby playing a pivotal role in respiratory physiology. Involved in the regulation of lipid droplet number and size.
  • 基因功能参考文献：
    1. fetal LPCAT1 mRNA present in maternal blood in quantity that correlates with lamellar body count PMID: 28926341
    2. The overexpression of LPCAT1 promotes the development and progression of ccRCC, likely through the conversion of LPC to PC. PMID: 28494778
    3. We found a direct correlation between LPCAT1 mRNA copies and the amniotic fluid lamellar body count. This finding corroborates an association between LPCAT1 and surfactant phospholipid biosynthesis. PMID: 25968427
    4. Overexpression of Lysophosphatidylcholine Acyltransferase 1 and Concomitant Lipid Alterations are associated with Gastric Cancer PMID: 25752890
    5. No disease causing mutations in the LPCAT1 gene were identified, indicating that LPCAT1 either does not confer a genetic predisposition to retinitis pigmentosa, or incidence of mutations in LPCAT1 is particularly rare in patients with retinitis pigmentosa. PMID: 26260533
    6. Down-regulation of LPCAT1 resulted in a decreased intercellular platelet-activating factor concentration and PAFR expression. PMID: 25803864
    7. LPCAT1 is an independent predictor of early tumor recurrence of breast carcinoma and represents a novel prognostic biomarker that reflects underlying biological alterations PMID: 25683484
    8. LPCAT1, a gene involved in the remodeling of phospholipids, was nominally associated with incident SCA risk. PMID: 24418166
    9. The prognostic impact of LPCAT1 expression was independent of histological and clinical parameters. It is concluded, that LPCAT1 measurement, either alone or in combination, may be utilized for better clinical decision-making. PMID: 23941784
    10. effect of LPCAT1 overexpression or knockdown on cell proliferation, migration, and invasion in hepatocellular carcinoma cell lines PMID: 23567080
    11. LPCAT1 correlates with the progression of prostate cancer. PMID: 22101258
    12. full LPCAT1 activity is required to achieve the levels of SatPC essential for the transition to air breathing PMID: 20407208
    13. hLPCAT1 is the biosynthetic enzyme of pulmonary surfactant phospholipids. PMID: 19383981
    14. Aytl2 gene is the phosphatidylcholine reacylating enzyme in RBCs; this represents the identification of a plasma membrane lysophospholipid acyltransferase and establishes the function of a LPCAT protein PMID: 18156367
    15. LPCAT1 may contribute to total choline metabolite accumulation via phosphatidylcholine remodeling, thereby altering the CRC lipid profile, a characteristic of malignancy. PMID: 18974965

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  • 亚细胞定位：
    Endoplasmic reticulum membrane; Single-pass type II membrane protein. Golgi apparatus membrane; Single-pass type II membrane protein. Cell membrane; Single-pass type II membrane protein. Lipid droplet.
  • 蛋白家族：
    1-acyl-sn-glycerol-3-phosphate acyltransferase family
  • 组织特异性：
    Erythrocytes.
  • 数据库链接：

    HGNC: 25718

    OMIM: 610472

    KEGG: hsa:79888

    STRING: 9606.ENSP00000283415

    UniGene: Hs.368853