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  4. Recombinant Human Lysosome membrane protein 2 (SCARB2), partial

Recombinant Human Lysosome membrane protein 2 (SCARB2), partial

  • 货号：
    CSB-YP619859HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP619859HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP619859HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP619859HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP619859HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    SCARB2
  • Uniprot No.：
  • 别名：
    85 kDa lysosomal membrane sialoglycoprotein; 85 kDa lysosomal sialoglycoprotein scavenger receptor class B member 2; AMRF; CD36; CD36 antigen (collagen type I receptor; thrombospondin receptor)-like 2 (lysosomal integral membrane protein II); CD36 antigen; CD36 antigen-like 2; CD36L2; EPM4; HLGP85; LGP85; LIMP 2; LIMP II; LIMP2; LIMPII; Lysosomal integral membrane protein II; Lysosome membrane protein 2; Lysosome membrane protein II; OTTHUMP00000160590; OTTHUMP00000219176; Scarb2; Scavenger receptor class B member 2; Scavenger receptor class B; member 2; SCRB2_HUMAN; SR BII; SRBII
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Acts as a lysosomal receptor for glucosylceramidase (GBA) targeting.; (Microbial infection) Acts as a receptor for enterovirus 71.
  • 基因功能参考文献：
    1. Crystal structure of a LIMP-2 luminal domain dimer with bound cholesterol and phosphatidylcholine is described. Binding of these lipids alters LIMP-2 from functioning as a glucocerebrosidase-binding monomer toward a dimeric state that preferentially binds anionic phosphatidylserine over neutral phosphatidylcholine. PMID: 29199275
    2. The binding of a monoclonal antibody to the apical region of SCARB2 blocks EV71 infection. PMID: 28447294
    3. The findings identify SR-BII as a functional SAA receptor that mediates SAA uptake and contributes to its proinflammatory signaling via the MAPK-mediated signaling pathways. PMID: 28423002
    4. In this paper we provide an updated overview of the clinical and genetic features of SCARB2-related PME and on the functions of the LIMP2 protein [review] PMID: 27582254
    5. neutrophils are able to drive a macrophage activation that would regulate the increase in LIMP-2 expression during the early phase of Cer-induced acute pancreatitis PMID: 26794464
    6. Findings suggested that STX1B rs4889603, FAM47E rs6812193 and SCARB2 rs6825004 do not confer a significant risk for Parkinson's disease PMID: 26224037
    7. LIMPII was increased greater than twofold in urinary microvesicles obtained from patients with idiopathic membranous nephropathy compared to microvesicles of patients with idiopathic focal segmental glomerulosclerosis and normal controls. PMID: 26304790
    8. Although hrGCase cellular uptake is independent of LIMP-2, its trafficking to the lysosomes is mediated by this receptor. PMID: 26018676
    9. SNCA and SCARB2 loci are also associated with dementia with Lewy bodies, after a study-wise Bonferroni correction, although these have a different association profile than the associations reported for the same loci in Parkinson's. PMID: 24973356
    10. a novel mutation in SCARB2 as a cause of progressive myoclonus epilepsy in China PMID: 24620919
    11. SCARB2 regulates TLR9-dependent IFN-I production of plasmacytoid dendritic cells PMID: 25862818
    12. Disease-causing cathepsin-F mutants fail to cleave LIMP-2. Our findings provide evidence that LIMP-2 represents an in vivo substrate of cathepsin-F with relevance for understanding the pathophysiology of type-B-Kufs-disease. PMID: 25576872
    13. Data indicate that scavenger receptor SCARB2 triggers uncoating of human enterovirus 71 (EV71) under low pH conditions. PMID: 24986489
    14. SCARB2 and PSGL-1 in human gastrointestinal tract, lung, and brain tissues correlated with the distribution of pathological changes seen in EV71 infection. PMID: 24997419
    15. In LIMP-2-deficient brains a significant reduction in GC activity led to lipid storage, disturbed autophagic/lysosomal function, and alpha-synuclein accumulation. PMID: 25316793
    16. The LIMP-2/SCARB2 binding sequences for enterovirus 71 and GCase are not similar, indicating that LIMP-2/SCARB2 may have multiple or overlapping binding sites with differing specificities. PMID: 25202012
    17. A novel SCARB2 mutation was indicated by reduced Beta-glucocerebrosidase activity in progressive myoclonus epilepsy. PMID: 24485911
    18. Mutations in LIMP-2, the specific receptor for glucocerebrosidase that is missing in Gaucher disease patients, substantially contribute to the pathology and heterogeneity of the disease. (Review) PMID: 24389070
    19. study of two Japanese siblings with late-onset progressive myoclonus epilepsy without renal failure having a novel homozygous SCARB2 mutation PMID: 23325613
    20. Human SCARB2-transgenic mice are a useful model for assessing anti-EV71 medications. PMID: 23451246
    21. Results suggest that this hSCARB2 transgenic mouse could represent a useful animal model for the study of enterovirus 71 (EV71) infection. PMID: 23959904
    22. identified no novel exonic variants in SCARB2 but confirmed the association between SNP rs6812193 and Parkinson's disease. PMID: 23408458
    23. SCARB2 is implicated in the lysosomal pathway recently associated with Parkinson disease (PD) pathogenesis. The rs6812193 polymorphism doesn't increase susceptibility to PD in the Greek population. PMID: 23473716
    24. These results indicated that SCARB2 is capable of viral binding, viral internalization, and viral uncoating and that the low infection efficiency of L-PSGL1 cells is due to the inability of PSGL1 to induce viral uncoating. PMID: 23302872
    25. Lysosomal storage disorders are associated with deficiencies of alternative lysosomal receptors LIMPII and sortilin and/or of their cargos. (Review) PMID: 22884962
    26. H171 residue in LIMP-2 is necessary for LIMP-2 and beta-glucocerebrosidase binding PMID: 22537104
    27. Our data do not support the association of SNP rs6812193 with PD in Han Chinese of mainland China. PMID: 22465138
    28. Two sisters are described with action myoclonus-renal failure (AMRF) syndrome resulting from a mutation in the SCARB2 gene. PMID: 21782476
    29. This study supported a genetic contribution of the SCARB2 locus to PD; future studies in larger cohorts are necessary to verify this finding. PMID: 22223122
    30. Coxsackievirus A infection is via celluar virus receptor SCARB2. PMID: 22438546
    31. Results show that EV71 binds to SCARB2 and triggers a clathrin- and dynamin-dependent endocytosis for its entry. PMID: 22272359
    32. Sequencing of SCARB2 genomic and cDNA identified a heterozygous, maternally inherited novel mutation (SCARB2 ) PMID: 21796727
    33. The residues between 144 and 151 are critical for SCARB2 binding to VP1 of EV71 and seven residues from the human receptor could convert murine SCARB2, an otherwise inefficient receptor, to an efficient receptor for EV71 viral infection. PMID: 22219187
    34. We showed that just four genes, G3BP2, SCARB2, CSNK1A1 and SPRR2B, can classify patients as presence of lymph node metastasis negative or positive, with 80.0% accuracy. PMID: 21985131
    35. in rare cases heterozygous SCARB2 mutations may be associated with demyelinating polyneuropathy features. PMID: 22032306
    36. This study demonistrated that patients with SCARB2 mutations showed the clinical and neurophysiologic phenotype of progressive myoclonus epilepsy , extending the spectrum reported in the typical action myoclonus renal failure syndrome. PMID: 22050460
    37. L929 cells expressing chimeras that carried amino acids 142 to 204 from the human sequence were susceptible to enterovirus 71, while chimeras that carried the mouse sequence in this region were not. PMID: 21389126
    38. Action Myoclonus-Renal Failure Syndrome-causing mutations within LIMP-2 affect the binding to beta-glucocerebrosidase. PMID: 19933215
    39. Several putative signalling motifs identified in the C-terminus of human SR-BII, which are absent from SR-BI, interact with signalling molecules to mobilize stored cholesteryl esters and/or promote the efflux of intracellular free cholesterol. PMID: 14570588
    40. High density lipoprotein endocytosis by scavenger receptor SR-BII is clathrin-dependent and requires a carboxyl-terminal dileucine motif. PMID: 16368683
    41. Residues favoring AP3 binding introduced into a protein that is transported via the PM such as the invariant chain can re-route such protein into direct sorting to late endosomal/lysosomal structures. PMID: 16542748
    42. SCARB2/Limp2 has pleiotropic effects that may be relevant to understanding the pathogenesis of other forms of glomerulosclerosis or collapse and myoclonic epilepsies. PMID: 18308289
    43. Scavenger receptor B2 is a cellular receptor for enterovirus 71. PMID: 19543282
    44. Study of SCARB2 mutations finds unsolved cases of progressive myoclonus epilepsy without renal impairment, especially those resembling Unverricht-Lundborg disease. PMID: 19847901
    45. Functional analysis of the mouse homolog PMID: 12620969

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  • 相关疾病：
    Epilepsy, progressive myoclonic 4, with or without renal failure (EPM4)
  • 亚细胞定位：
    Lysosome membrane; Multi-pass membrane protein.
  • 蛋白家族：
    CD36 family
  • 数据库链接：

    HGNC: 1665

    OMIM: 254900

    KEGG: hsa:950

    STRING: 9606.ENSP00000264896

    UniGene: Hs.349656