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  4. Recombinant Human Mammaglobin-A (SCGB2A2)

Recombinant Human Mammaglobin-A (SCGB2A2)

  • 货号：
    CSB-YP622649HU
  • 规格：
    ￥1500
  • 图片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

产品详情

  • 纯度：
    Greater than 85% as determined by SDS-PAGE.
  • 基因名：
    SCGB2A2
  • Uniprot No.：
  • 别名：
    Mammaglobin 1; Mammaglobin-1; Mammaglobin-A; MGB1; Scgb2a2; Secretoglobin family 2A member 2; SG2A2; SG2A2_HUMAN; UGB2
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 来源：
    Yeast
  • 分子量：
    10.5 kDa
  • 表达区域：
    19-93aa
  • 氨基酸序列
    GSGCPLLENVISKTINPQVSKTEYKELLQEFIDDNATTNAIDELKECFLNQTDETLSNVEVFMQLIYDSSLCDLF
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 6xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    25-35 business days
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 基因功能参考文献：
    1. Results support a role for MGB1 in breast cancer malignancy in exchange for chemosensitivity. PMID: 26207726
    2. good coincidence was observed between primary and metastatic tumor GATA3 expression (kappa value = 0.826 >0.75) as compared with the coincidence of GCDFP15 (kappa value =0.492 <0.75) and mammaglobin (kappa value =0.593 <0.75) PMID: 28038704
    3. Expression of MGB1 was higher in breast cancer than non-malignant tissue and it decreased during breast cancer progression. PMID: 27563000
    4. trefoil factor 1 demonstrated breast specificity but was inferior to mammaglobin and GATA protein binding 3 PMID: 26276775
    5. Mammaglobin-A immunohistochemistry in primary central nervous system neoplasms and intracranial metastatic breast carcinoma. Cimino PJ Jr, Perrin RJ PMID: 23958549
    6. Overexpression of hMAM in breast cancer cells decreased migration and invasion, whereas knockdown of hMAM increased both. PMID: 24328556
    7. Mammaglobin immunohistochemistry is useful as a proxy marker for the ETV6-NTRK3 translocation in the diagnosis of salivary mammary analogue secretory carcinoma. PMID: 23773480
    8. High peripheral blood mammaglobin gene expression is associated with metastasis in breast cancer. PMID: 22897908
    9. Gross cystic disease fluid protein-15 and mammaglobin A expression determined by immunohistochemistry is of limited utility in triple-negative breast cancer. PMID: 22963676
    10. MGB1 was detected in endometrial tissue, with peak expression during the luteal phase, in 31% of endometriotic samples, in 53% of endometrial adenocarcinomas, and in 64% of breast carcinomas. PMID: 22994369
    11. Qualitative detection of plasma hMAM mRNA appears to be associated with unfavorable prognostic factors and lower rates of event-free survival in patients with breast cancer. PMID: 23212340
    12. Data show that HLA-A24-restricted, mammaglobin-A (Mam-A) derived, CD8(+) cytotoxic T lymphocyte (CTL) epitopes that can potentially be employed for Mam-A-based breast cancer vaccine therapy to breast cancer patients with HLA-A24 phenotype. PMID: 22074997
    13. A decrease in MGB1+mRNA levels (baseline-week 8) seemed to be associated with clinical response (P = 0.05). PMID: 21976532
    14. MGA detection by the modified nested RT-PCR is a specific marker for circulating tumor cells in patients with breast carcinoma and a negative prognostic factor for the disease PMID: 21939647
    15. High serum mammaglobin is associated with breast cancer. PMID: 21744998
    16. The current knowledge regarding the use of reverse-transcriptase PCR for detecting human mammaglobin mRNA as a biomarker for circulating tumor cells in breast cancer patients, is reviewed. PMID: 21473729
    17. The expression of hMAG was found to be increased with breast cancer grade. PMID: 21623075
    18. Most basal-like breast carcinomas and unclassified triple-negative carcinomas are negative for mammaglobin and gross cystic disease fluid protein 15. PMID: 21411781
    19. Detection of Mammaglobin as part of a 3-marker RT-PCR for early diagnosis of breast cancer. PMID: 20586026
    20. detection of mammaglobin mRNA is useful to determine the effect of therapy while maspin transcripts may indicate more aggressive disease. PMID: 20092039
    21. Expression of MGB1 transcript is associated with breast cancer PMID: 14696125
    22. MGB1 markers may be useful for identifying micrometastases in sentinel lymph nodes of breast cancer patients. PMID: 15151203
    23. Mammaglobin has a role in progression of breast cancer, as shown by its expression in leukapheresis products PMID: 15447988
    24. MGA protein exists in 2 main forms in breast neoplasms PMID: 15609337
    25. occult blood hMAM mRNA can be detected by RT-PCR and may have a role in progression of breast neoplasms PMID: 16110760
    26. mammaglobin expression is associated with expression of estrogen receptor and progesteron receptor in metastasizing breast cancer [letter] PMID: 16203799
    27. MGB1 transcript in peripheral blood of breast cancer patients was specific but with low sensitivity. MGB1 overexpression by itself or in combination with Ki67 might be considered an index of breast cancer rogression PMID: 16760290
    28. mammaglobin mRNA is expressed in breast cancer tissue PMID: 16761620
    29. Mammaglobin A is a highly specific molecular marker for the detection of circulating tumor cells in operable breast cancer, with important prognostic applications. PMID: 16925986
    30. MGB1 immunohistochemistry can serve as a differential marker of breast cancer metastasis from primary lung cancer. PMID: 17192791
    31. successfully generated MGB-specific CD4 T cell cultures and identified candidate MGB HLA class II epitopes PMID: 17653857
    32. The sensitivity of mammaglobin is equal or superior to that of GCDFP-15 for investigation of breast carcinoma. PMID: 18251583
    33. mammaglobin mRNA in peripheral blood may have a role in progression of breast cancer PMID: 18289390
    34. RT-PCR for hMAM test was more sensitive than cytomorphology of breast cancer derived pleural effusion. PMID: 18303409
    35. The overexpression of mammaglobin observed in certain breast tumors is an epiphenomenon not causally involved in breast carcinogenesis. PMID: 18630503
    36. This study demonstrated that human mammaglobin transcripts are expressed in the CSF of a BC patient with LM carcinomatosis. PMID: 18841443
    37. Breast cancer patients with pre-operative elevated bone marrow levels of Mammaglobin Aand/or trefoil factor 1 mRNA seem to constitute a small group of patients with a very poor prognosis. PMID: 18846421
    38. Both MGB1 and GCDFP-15 are specific markers for metastatic breast carcinomas in cell block fluid specimens (88 vs. 96%). PMID: 19217055
    39. Mammaglobin is a sensitive marker of breast carcinoma, it defines a subgroup of patients with better prognosis and is a useful method to detect breast cancer metastases. PMID: 19690758

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Secretoglobin family, Lipophilin subfamily
  • 组织特异性：
    Mammary gland specific. Over-expressed in breast cancer.
  • 数据库链接：

    HGNC: 7050

    OMIM: 605562

    KEGG: hsa:4250

    STRING: 9606.ENSP00000227918

    UniGene: Hs.46452