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  4. Recombinant Human Max-interacting protein 1 (MXI1)

Recombinant Human Max-interacting protein 1 (MXI1)

  • 中文名称：
    人MXI1重组蛋白
  • 货号：
    CSB-YP015254HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人MXI1重组蛋白
  • 货号：
    CSB-EP015254HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人MXI1重组蛋白
  • 货号：
    CSB-EP015254HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人MXI1重组蛋白
  • 货号：
    CSB-BP015254HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人MXI1重组蛋白
  • 货号：
    CSB-MP015254HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    MXI1
  • Uniprot No.：
  • 别名：
    bHLHc11; Class C basic helix-loop-helix protein 11; MAD 2; MAD2; MAX dimerization protein 2; MAX interacting protein 1; Max interactor 1; Max related transcription factor; MAX-interacting protein 1; MGC43220; MXD 2; MXD2; MXI 1; MXI; mxi1; MXI1 protein; MXI1_HUMAN; Protein MXI1
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-228
  • 氨基酸序列
    MERVKMINVQ RLLEAAEFLE RRERECEHGY ASSFPSMPSP RLQHSKPPRR LSRAQKHSSG SSNTSTANRS THNELEKNRR AHLRLCLERL KVLIPLGPDC TRHTTLGLLN KAKAHIKKLE EAERKSQHQL ENLEREQRFL KWRLEQLQGP QEMERIRMDS IGSTISSDRS DSEREEIEVD VESTEFSHGE VDNISTTSIS DIDDHSSLPS IGSDEGYSSA SVKLSFTS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcriptional repressor. MXI1 binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. MXI1 thus antagonizes MYC transcriptional activity by competing for MAX.
  • 基因功能参考文献：
    1. Reactive oxygen species mediates hypoxia-induced VEGF by upregulation of Mxi1-0. PMID: 28065785
    2. results suggest that Mxi1-0 regulates the growth of HUVECs via the IL-8 and ERK1/2 pathways, which apparently reciprocally activate each other PMID: 28575053
    3. MYC-HEG and MXI1-LEG levels are associated with poor prognosis in patients with breast cancer, suggesting that they may be useful molecular markers in breast cancer prognosis prediction. PMID: 24685915
    4. MicroRNA-155 promotes glioma cell proliferation via the regulation of MXI1. PMID: 24376632
    5. MXI1-0 appears to be a downstream target of MYCN-dependent signaling pathways and may contribute to N-Myc-dependent cell growth and proliferation. PMID: 24403858
    6. These findings reveal, for the first time, the novel functions of cooperation of miR243p and miR27a3p from two clusters in promoting cell proliferation through MXI1. PMID: 23254855
    7. Mxi1 can act as a tumour suppressor in human glioblastomas through a molecular mechanism involving the transcriptional down-regulation of cyclin B1 gene expression. PMID: 11875718
    8. These findings support MXI1 as a putative tumor suppressor gene involved in conventional melanoma progression. PMID: 14559981
    9. Mxi1-SRalpha is an isoform with enhanced transcriptional repression potential PMID: 15467743
    10. Data show that PTEN and MXI1 were two candidate tumor suppressor genes on 10q23 and 10q24-q25 and may be potentially involved in the initiation and progression of prostate carcinoma. PMID: 15476185
    11. Mxi-D may play an important role in the c-Myc family protein network acting as a dominant negative isoform of Mxi-F stimulated by c-Myc PMID: 15809730
    12. p300 can acetylate DNA-bound Myc:Max complexes and that acetylated Myc:Max heterodimers efficiently interact with Miz-1 PMID: 16126174
    13. MXI1 mutation appears to play a role in the pathogenesis of a small subset of cases, and suggests an alternative mechanism to MYC amplification for disruption of the MYC/MAD/MAX network in medulloblastoma. PMID: 17102621
    14. These results provide evidence of direct regulation of Mxi1 by FOXO3a and imply an additional mechanism through which the PI3-kinase/Akt/FOXO pathway can modulate Myc function. PMID: 17452451
    15. Mad1, Mxi1 and Rox genes were expressed and displayed mutations in haematological malignancies. PMID: 17577784
    16. Mxi1 gains functional complexity by encoding isoforms with shared and distinct activities PMID: 17697116
    17. Missense mutations in Mad1, Mxi1 and Rox were found in acute leukemia patients. PMID: 18457265
    18. Mxi1 is an important downstream target of HIF that contributes to pVHL-deficient renal cancer tumorigenesis PMID: 19018165
    19. MAX interactor-1 (MXI1) gene is directly regulated by HIF-1alpha protein in neuroblastoma and breast cancer cells. PMID: 19254710

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  • 相关疾病：
    Prostate cancer (PC)
  • 亚细胞定位：
    Nucleus.
  • 组织特异性：
    High levels found in the brain, heart and lung while lower levels are seen in the liver, kidney and skeletal muscle.
  • 数据库链接：

    HGNC: 7534

    OMIM: 176807

    KEGG: hsa:4601

    STRING: 9606.ENSP00000331152

    UniGene: Hs.602078