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  4. Recombinant Human Membrane metallo-endopeptidase-like 1 (MMEL1), partial

Recombinant Human Membrane metallo-endopeptidase-like 1 (MMEL1), partial

  • 中文名称：
    人MMEL1重组蛋白
  • 货号：
    CSB-YP014654HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人MMEL1重组蛋白
  • 货号：
    CSB-EP014654HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人MMEL1重组蛋白
  • 货号：
    CSB-EP014654HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人MMEL1重组蛋白
  • 货号：
    CSB-BP014654HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人MMEL1重组蛋白
  • 货号：
    CSB-MP014654HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    MMEL1
  • Uniprot No.：
  • 别名：
    Mel transforming oncogene like 1; Membrane metallo endopeptidase like 1 ; Membrane metallo endopeptidase like 2; Membrane metallo-endopeptidase-like 1; Membrane metallo-endopeptidase-like 2; MMEL1; MMEL1_HUMAN; NEP2; NEP2(m); NEP2(s); NEPII; Neprilysin 2; Neprilysin II; Neprilysin Like 1; Neprilysin-2; Neprilysin-2 secreted; Neprilysin-like Protease beta; Neprilysin-like Protease gamma; NL1; NL2; SEP; soluble form; Soluble secreted endopeptidase
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Metalloprotease involved in sperm function, possibly by modulating the processes of fertilization and early embryonic development. Degrades a broad variety of small peptides with a preference for peptides shorter than 3 kDa containing neutral bulky aliphatic or aromatic amino acid residues. Shares the same substrate specificity with MME and cleaves peptides at the same amide bond.
  • 基因功能参考文献：
    1. the dynamic behavior of human NEP and NEP2 proteins was monitored by conducting molecular dynamics (MD) simulations. PMID: 26846903
    2. MMEL1 518 Met/Thr polymorphism contributes to celiac disease risk among Saudi Arabians, both in single and also in synergistic cooperation with SH2B3 gene marker. PMID: 26843707
    3. Te results of this study suggested taht genetic variations in MMEL1, ECE1, ECE2, AGER, PLG, PLAT, NR1H3, MMP3, LRP1, TTR, NR1H2, and MMP9 genes do not play major role among the Finnish AD patient cohort. PMID: 22027013
    4. The NEP2 expression and activity are altered in MCI is significant as these changes may potentially serve as preclinical markers for AD and reduced NEP2 activity may be associated with the development of Alzheimer's disease. PMID: 22008264
    5. This study identifies MMEL1 and CTLA4 as RA susceptibility genes, in Han Chinese popilation. PMID: 21784728
    6. A combined analysis of the nsSNP screen and replication data provides evidence implicating a novel additional locus, rs3748816 in membrane metalloendopeptidase-like 1 in multiple sclerosis susceptibility. PMID: 20574445
    7. NEP2 substrate specificity and inhibitor binding was distinct from that of human NEP, suggesting that NEP and NEP2 play distinct physiological roles in humans. PMID: 18539150

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  • 亚细胞定位：
    Membrane; Single-pass type II membrane protein. Secreted.
  • 蛋白家族：
    Peptidase M13 family
  • 组织特异性：
    Predominantly expressed in testis. Weakly expressed in brain, kidney and heart.
  • 数据库链接：

    HGNC: 14668

    KEGG: hsa:79258

    STRING: 9606.ENSP00000367668

    UniGene: Hs.591453