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  4. Recombinant Human Metallothionein-2 (MT2A), partial

Recombinant Human Metallothionein-2 (MT2A), partial

  • 中文名称：
    人MT2A重组蛋白
  • 货号：
    CSB-EP015120HU
  • 规格：
    ￥1344
  • 图片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

产品详情

  • 纯度：
    Greater than 90% as determined by SDS-PAGE.
  • 基因名：
    MT2A
  • Uniprot No.：
  • 别名：
    MT2A; CES1; MT2; Metallothionein-2; MT-2; Metallothionein-2A; Metallothionein-II; MT-II
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 来源：
    E.coli
  • 分子量：
    32.9kDa
  • 表达区域：
    1-59aa
  • 氨基酸序列
    MDPNCSCAAGDSCTCAGSCKCKECKCTSCKKSCCSCCPVGCAKCAQGCICKGASDKCSC
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal GST-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Tris-based buffer,50% glycerol
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.
  • 基因功能参考文献：
    1. this study uncovers an important role for XAF1-MT2A antagonism as a linchpin to govern cell fate under various stressful conditions including heavy metal exposure. PMID: 28507149
    2. There are evidence for implicating MT2A polymorphisms in the development of Sinonasal Inverted Papilloma. The findings also illustrate the key role played by the MT2A gene in inducing an aggressive Schneiderian Papilloma phenotype. PMID: 28432463
    3. MT2A A-5G polymorphism may be associated with risk of developing chronic kidney disease and diabetes. PMID: 27122239
    4. Data suggest that genotype AA for SNP rs28366003 in MT2A is associated with higher blood zinc levels in subjects with diabetes type 2 (with chronic kidney disease) as compared to control subjects. This case-control, genetic association study was conducted in the Czech Republic. PMID: 28059470
    5. We found a significant association of SNP rs28366003 at MT2A gene with susceptibility to the dry form of AMD in a Northern Spanish population. PMID: 28635422
    6. Our results indicated that the rs10636 and rs28366003 polymorphisms in MT2A increased breast cancer risk in Northwest Chinese Han population. PMID: 28228606
    7. the association of the blood lead level and HDL-C may be modified by the MT2A genetic combination PMID: 28391890
    8. The facility of forming bead-like structures at physiological pH for Zn5-MT2a means that Zn7-MT2a can donate up to two Zn(II) to Zn-dependent enzymes. PMID: 28865957
    9. MT2A may be a chemosensitivity indicator in gastric cancer patients receiving docetaxel-based treatment. PMID: 26801633
    10. Underexpression of MT2A is associated with HPV-positive head and neck cancers. PMID: 26666815
    11. HMBOX1 regulates intracellular free zinc level by interacting with MT2A to inhibit apoptosis and promote autophagy in vascular endothelial cells. PMID: 26456220
    12. Polymorphism of Metallothionein 2A modifies Lead Body Burden in workers chronically exposed to the metal. PMID: 26594907
    13. The findings suggest that MT2A gene variation rs28366003 may be implicated in the etiology of sinonasal inverted papilloma in a Polish population PMID: 26036762
    14. Metallothionein 2A affects the cell respiration by suppressing the expression of mitochondrial protein cytochrome c oxidase subunit II. PMID: 25808318
    15. Data suggest that blood metallothionein-2A (MT-2A) expression and serum MT-2A levels could be important prognostic indices of less differentiated, more aggressive breast cancer phenotype. PMID: 26093198
    16. MT2A was down-regulated in renal cell carcinogenesis. PMID: 24662736
    17. In the Han population of China, the gene polymorphism of MT2A-838G/C is correlated to coronary heart disease. PMID: 25555862
    18. Electrospray ionization ion mobility mass spectrometry and molecular dynamics simulations reveal new insights into metal-induced conformational changes and the mechanism for metalation of human metallothionein-2A. PMID: 24918957
    19. MT2A mRNA expression has a significant inverse correlation with Cd and Cu levels in dry inverted papilloma tissue. Inverted papilloma cases with lower average cadmium and copper content were observed to be the most frequent positive MT2A mRNA expression. PMID: 25900616
    20. A genetic variation of MT2A may be a risk factor in laryngeal cancer in a Polish population and the presence of -5 A/G (rs28366003) MT2A gene polymorphism could be considered as a new potential biomarker of the invasive phenotype of laryngeal cancer. PMID: 24952512
    21. -5 A/G SNP in MT2A gene may have an effect on allele-specific gene expression and accumulation of metal levels in laryngeal cancer. PMID: 25157674
    22. These data suggest that the rs28366003 single nucleotide polymorphism in MT2A is associated with risk of breast cancer in Polish population. PMID: 23053628
    23. Low MT2A expression is associateed with lung carcinogenesis. PMID: 23947958
    24. MT2A contributes to chemotherapy resistance in osteosarcoma, an effect partially mediated by zinc chelation. PMID: 24157868
    25. Cotreatment with aryl hydrocarbon receptor agonist and dexamethasone enhances human MT2A gene expression. PMID: 23994556
    26. MT2A might play a tumor suppressive activity through inhibiting NF-kappaB signaling PMID: 23870553
    27. Suggest a potential role of MT-I/II in the proliferation of gastrointestinal stromal tumor cells and disease progression. PMID: 23986211
    28. MiR-23a in amplified 19p13.13 loci targets metallothionein 2A and promotes growth in gastric cancer cells. PMID: 23553990
    29. Data suggest that up-regulation of MT2A expression in hepatic stellate cells down-regulates expression of specific biological markers (alpha-smooth muscle actin; collagen-I; collagenases) and up-regulates others (matrix metalloproteinases 1, 8, 13). PMID: 23620539
    30. Metallothionein overexpression in cardiac myocytes is capable of abolishing an otherwise expected significant diabetic capillary basement membrane thickening. PMID: 23381845
    31. suggest that Mt2a might be involved in insulin resistance through the up-regulation of Mt gene expression, which may lead to the modulation of insulin action in fat cells PMID: 23148893
    32. A significant association between rs28366003 genotype and MT2A expression level is found in prostate cancer patients. PMID: 23466427
    33. findings show 5 MT isoforms were overexpressed in non-small cell lung cancer and overexpression of MT-1F and MT-2A predicted poor outcome; both isoforms may be involved in progression of this cancer type PMID: 23064051
    34. MT-I/II expression was increased in hippocampi from temporal lobe epilepsy. PMID: 23028585
    35. pregnant women with AG genotype for MT2A polymorphism might have high blood lead levels and their newborns may be at risk of low-level cord blood lead variation PMID: 22005883
    36. Investigated whether MT2A gene polymorphisms are associated with a risk of prostate cancer. Three MT2A SNPs were genotyped in 358 prostate cancer cases and 406 population controls; one SNP showed a positive association with prostate cancer. PMID: 22824183
    37. High MT2A is associated with prostate cancer. PMID: 22248277
    38. MT2A -5A/G core promoter region single nucleotide polymorphism has an effect in accumulating placental Cd and transferring maternal to fetal essential micronutrients. PMID: 21328412
    39. these data support that the IL-6 -174 C+ carriers and MT2A -5 G- carriers may be more advantageous for longevity. PMID: 21277639
    40. Highly statistically significant associations are detected between the -5 adenine/guanine core promoter region single nucleotide polymorphism in the MT2A gene and cadmium, lead, and zinc (but not copper) blood levels. PMID: 21767559
    41. Data suggest that increase in cell size, intracellular granulation and megakaryocytic specific antigen expression such as CD41 and CD42, and arresting cell proliferation validate the role of metallothioneins in cell differentiation. PMID: 20127519
    42. MT-I/II may play a key role in IDC proliferation, but is not a useful prognostic factor of this disease PMID: 21868554
    43. MT-2A promotes breast cancer cell invasion by upregulating MMP-9 via AP-1 and NF-kappaB activation. PMID: 21187089
    44. metallothioneins represented by MT-2A capable of protecting against Abeta aggregation and toxicity PMID: 20711450
    45. MT2 diminishes Transthyretin-Abeta binding, whereas MT3 has the opposite effect PMID: 20646067
    46. The core promoter region polymorphism of metallothionein 2A increases the accumulation of Cd in human renal cortex. PMID: 20303360
    47. A --> G single-nucleotide polymorphism was deteceted in metallothionein 2A core promoter region of Turkish population. PMID: 19572214
    48. Transgenic mice overexpressing human metallothionein 2A from a cardiac-specific promoter were protected from doxorubicin cardiotoxicity. MT can protect the heart from oxidative injury only if it is present prior to induction of oxidative stress. PMID: 12192109
    49. Data suggest that the physical interaction of esophageal cancer related gene 2 (ECRG2) and metallothionein 2A (MT2A) may play an important role in the carcinogenesis of esophageal cancer. PMID: 12646258
    50. zinc ion bioavailability by zinc-bound MTs homeostasis is pivotal to reach health longevity and successful ageing. PMID: 12714254

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  • 蛋白家族：
    Metallothionein superfamily, Type 1 family
  • 数据库链接：

    HGNC: 7406

    OMIM: 156360

    KEGG: hsa:4502

    STRING: 9606.ENSP00000245185

    UniGene: Hs.534330