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  4. Recombinant Human Methionine synthase (MTR), partial

Recombinant Human Methionine synthase (MTR), partial

  • 中文名称：
    人MTR重组蛋白
  • 货号：
    CSB-YP859939HU
  • 规格：
    ￥1500
  • 图片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

产品详情

  • 纯度：
    Greater than 90% as determined by SDS-PAGE.
  • 基因名：
    MTR
  • Uniprot No.：
  • 别名：
    MTRMethionine synthase; EC 2.1.1.13; 5-methyltetrahydrofolate--homocysteine methyltransferase; Vitamin-B12 dependent methionine synthase; MS
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 来源：
    Yeast
  • 分子量：
    41.0kDa
  • 表达区域：
    923-1265aa
  • 氨基酸序列
    SLKERRYLPLSQARKSGFQMDWLSEPHPVKPTFIGTQVFEDYDLQKLVDYIDWKPFFDVWQLRGKYPNRGFPKIFNDKTVGGEARKVYDDAHNMLNTLISQKKLRARGVVGFWPAQSIQDDIHLYAEAAVPQAAEPIATFYGLRQQAEKDSASTEPYYCLSDFIAPLHSGIRDYLGLFAVACFGVEELSKAYEDDGDDYSSIMVKALGDRLAEAFAEELHERVRRELWAYCGSEQLDVADLRRLRYKGIRPAPGYPSQPDHTEKLTMWRLADIEQSTGIRLTESLAMAPASAVSGLYFSNLKSKYFAVGKISKDQVEDYALRKNISVAEVEKWLGPILGYDTD
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 6xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Tris-based buffer,50% glycerol
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Catalyzes the transfer of a methyl group from methylcob(III)alamin (MeCbl) to homocysteine, yielding enzyme-bound cob(I)alamin and methionine in the cytosol. MeCbl is an active form of cobalamin (vitamin B12) used as a cofactor for methionine biosynthesis. Cob(I)alamin form is regenerated to MeCbl by a transfer of a methyl group from 5-methyltetrahydrofolate. The processing of cobalamin in the cytosol occurs in a multiprotein complex composed of at least MMACHC, MMADHC, MTRR (methionine synthase reductase) and MTR which may contribute to shuttle safely and efficiently cobalamin towards MTR in order to produce methionine.
  • 基因功能参考文献：
    1. 12 articles were included in this study. The pooled results did not reveal a significant association of the MTR A2756G polymorphism with Nonsyndromic Cleft Lip With or Without Cleft Palate risk (G vs. A: OR = 0.95, 95% CI = 0.82-1.11, p = 0.55). PMID: 30004262
    2. GG homozygous and G alleles of methionine synthase A2756G polymorphism were not associated with risks of non-Hodgkin lymphoma (NHL), Hodgkin lymphoma (HL), the subtype of NHL including the diffuse large B-cell lymphoma and follicular lymphoma. PMID: 28742198
    3. Data indicate that two noncoding 5-methyltetrahydrofolate-homocysteine methyltransferase (MTR) variants, rs28372871 and rs1131450 were independently associated with a significantly increased risk of prostate cancer (PCa). PMID: 27808252
    4. no difference in genotype frequencies between pre-eclampsia patients and controls PMID: 27806663
    5. Based on the results, an MTRA2756G polymorphism which changes activity and stability of the methionine synthase associated with prostate cancer in men. PMID: 28724269
    6. MTR CpG sites were hypermethylated in preterm placenta. Methylated CpG sites were negatively associated with maternal plasma vitamin B12 levels. PMID: 28617183
    7. MS A2756G polymorphism may not be a risk factor for hematological cancer. PMID: 29310321
    8. MTHFR A1298C and MS A2756G polymorphisms may be unrelated to male infertility. PMID: 28081209
    9. People with late-life depression carrying MTR2756 AA genotype have higher risk of cognitive impairment than those carrying G allele. PMID: 27111719
    10. Data suggest that the MTR-A2756G polymorphism is associated with male infertility risk. PMID: 26905524
    11. MTR A2756G single nucleotide polymorphism is significantly associated with gastric cancer risk in Korea. PMID: 26833750
    12. There was a significant positive correlation between serum concentrations of vitamin B12 and regional GM (grey matter ) volume in APOE epsilon4 carriers with AD but not in non-carriers. PMID: 25919635
    13. According to our results, the MTR A2756G polymorphism was associated with the risk of retinoblastoma in Iranian patients. PMID: 26595280
    14. MTR genetic polymorphisms are risk factor for predicting cardiovascular manifestations in Marfan syndrome. PMID: 26063524
    15. no association of rs1805087 with non-obstructive azoospermia PMID: 26196053
    16. Data suggest impaired folate metabolism down-regulates placenta trophoblast proliferation, viability, invasive capacity, and progesterone secretion; silencing MTR gene down-regulates cell proliferation and up-regulates progesterone secretion. PMID: 26299783
    17. Studies do not indicate a major role of the 5-methyltetrahydrofolate-homocysteine methyltransferase (MTR) rs1805087 A> G polymorphism in modulating non-Hodgkin lymphoma (NHL) risk. PMID: 24956146
    18. An increase of placental mRNA levels in the pre-eclampsia group was observed for MTR and cystathionine gamma-lyase. PMID: 25801727
    19. Methionine synthase (MTR) and methionine synthase reductase (MTRR) polymorphisms were significantly associated with the increased neural tube defects risk in a Chinese population. PMID: 26334892
    20. In summary, hyperhomocysteinemia was related with increased risk of decline in executive functioning, complex attention, cognitive flexibility, and memory in postmenopausal women. PMID: 25822709
    21. Results show that an association of the G-allele of the methionine synthase variant c.2756A>G (D919G) with global DNA methylation. PMID: 25531253
    22. Our results show that elevated homocysteine plasma level may characterize schizophrenia patients' male siblings. PMID: 24051177
    23. results suggest that methionine synthase in the villous trophoblast participates in the metabolism of homocysteine by using folate PMID: 25277375
    24. our study provides evidence suggesting that MTR A2756G is associated with a reduced risk of developing childhood ALL. PMID: 23906019
    25. 5-methyltetrahydrofolate-homocysteine methyltransferase gene polymorphism does not have modification effects on the risk of CRC. PMID: 25077679
    26. Genetic association replicative and exploratory studies identify SNPs in ADA and MTR highly associated with isolated Neural tube defects (NTD)and SNP in ARID1A and ALDH1A2 associated with NTDs in whites and African Americans respectively. PMID: 25293959
    27. Our findings suggest a causal role for maternal homocysteine (1-C metabolism) in fetal growth PMID: 25052622
    28. This meta-analysis demonstrated a suggestive result that the A66G variant in MTRR, but not the A2756G in MTR, may be associated with the increase of congenital heart disease risks. PMID: 24595101
    29. found limited evidence that the maternal MTR rs1804742 appeared to interact with higher folic acid levels to influence childhood acute lymphoblastic leukemia risk PMID: 24087922
    30. Results show that regulatory variants of the MTR gene increase CHD risk by reducing MTR expression and inducing the homocysteine accumulation and elevation. PMID: 23798577
    31. Trend analyses also revealed the marginally significant lower risk of chronic kidney disease with increasing number of MTR A2756G G allele. PMID: 23595572
    32. Present data do not support a role for MTR 2756A>G as independent maternal risk factor for a Down syndrome birth. PMID: 24150725
    33. data suggest that the interaction of methionine synthase with MMACHC may play a role in the regulation of the cellular processing of cobalamins that is required for cobalamin cofactor synthesis PMID: 23825108
    34. No association between MS A2756G polymorphism and cervical cancer was detected in the worldwide population. PMID: 23864153
    35. [meta-analysis] MTR A2756G polymorphisms are not associated with risks for neural tube defects in Caucasian children. PMID: 23425389
    36. There was a significant association of breast cancer risk with MTR 2756 GG and AA polymorphism. PMID: 24166605
    37. A review of the influences of genetic polymorphisms in methionine synthase on the occurrence of adverse effects from methotrexate therapy. PMID: 23986219
    38. MTR 2756 AA genotypes were associated with higher Hcy concentrations (16.6 and 10.1 mumol/L; p<0.05) compared to subjects harboring the MTHFR 677 CT/CC and the MTR 2756 AG genotypes (10.5, 9.7 and 9.5 mumol/L, respectively). PMID: 23954866
    39. MTR SNPs do not appear to play a major role in lymphoma susceptibility in a Spanish population. PMID: 23818366
    40. This meta-analysis suggests that there is no significant association between the MTR A2756G polymorphism and digestive system cancer risk. PMID: 23613867
    41. findings suggest that MTR A2756G polymorphism is not associated with altered susceptibility to breast cancer, while the observed decreased risk in Caucasians PMID: 23845785
    42. MTR A2756G polymorphism is not associated with CRC/CRA susceptibility and that gene-environment interaction may exist. PMID: 23593229
    43. Methionine synthase 2756AA genotype and 2756A-TS 6-bp allele combination are predisposing factors for recurrent pregnancy loss in a sample of South Korean women. PMID: 23415967
    44. no associations between the MTR A2756G polymorphism and neural tube defects risk were found in meta-analysis of genetic models PMID: 23438943
    45. no significant association was found between TYMS or the MTR polymorphisms and the risk of primary liver cancer PMID: 21956592
    46. meta-analysis indicated that MTRR A66G polymorphism, but not MTR A2756G, is significantly associated with maternal risk for neural tube defects in Caucasians PMID: 23266814
    47. These findings indicate that locus A2756G in the MTR gene may play a role in susceptibility to congenital anomalies of the cardiovascular system in West Siberia. PMID: 22855024
    48. an increase in the risk of colorectal adenomas associated with methionine synthase 2756GG genotype PMID: 22407825
    49. No statistically significant association with prostate cancer was detected for the polymorphic locus A2756G of methionine synthase gene. PMID: 22803112
    50. We found weak evidence of a recessive effect of the G allele in MTR A2756G (odds ratio, 1.61 [95% confidence interval, 0.98-2.66]; p=0.06)and risk for coronaryh artery diseae. PMID: 22339686

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  • 相关疾病：
    Homocystinuria-megaloblastic anemia, cblG complementation type (HMAG); Neural tube defects, folate-sensitive (NTDFS)
  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    Vitamin-B12 dependent methionine synthase family
  • 组织特异性：
    Widely expressed. Expressed at the highest levels in pancreas, heart, brain, skeletal muscle and placenta. Expressed at lower levels in lung, liver and kidney.
  • 数据库链接：

    HGNC: 7468

    OMIM: 156570

    KEGG: hsa:4548

    STRING: 9606.ENSP00000355536

    UniGene: Hs.498187