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  4. Recombinant Human Methylthioribose-1-phosphate isomerase (MRI1)

Recombinant Human Methylthioribose-1-phosphate isomerase (MRI1)

  • 货号：
    CSB-YP863127HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP863127HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP863127HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP863127HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP863127HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    MRI1
  • Uniprot No.：
  • 别名：
    EI2BL; M1Pi; Mediator of RhoA-dependent invasion; Methylthioribose 1 phosphate isomerase 1; Methylthioribose 1 phosphate isomerase homolog; Methylthioribose-1-phosphate isomerase; MGC3207; MRDI; mri1; MTNA; MTNA_HUMAN; MTR-1-P isomerase; S methyl 5 thioribose 1 phosphate isomerase 1; S-methyl-5-thioribose-1-phosphate isomerase; Translation initiation factor eIF 2B; Translation initiation factor eIF-2B subunit alpha/beta/delta-like protein; Ypr118w
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-369
  • 氨基酸序列
    MTLEAIRYSR GSLQILDQLL LPKQSRYEAV GSVHQAWEAI RAMKVRGAPA IALVGCLSLA VELQAGAGGP GLAALVAFVR DKLSFLVTAR PTAVNMARAA RDLADVAARE AEREGATEEA VRERVICCTE DMLEKDLRDN RSIGDLGARH LLERVAPSGG KVTVLTHCNT GALATAGYGT ALGVIRSLHS LGRLEHAFCT ETRPYNQGAR LTAFELVYEQ IPATLITDSM VAAAMAHRGV SAVVVGADRV VANGDTANKV GTYQLAIVAK HHGIPFYVAA PSSSCDLRLE TGKEIIIEER PGQELTDVNG VRIAAPGIGV WNPAFDVTPH DLITGGIITE LGVFAPEELR TALTTTISSR DGTLDGPQM
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Independently from catalytic activity, promotes cell invasion in response to constitutive RhoA activation by promoting FAK tyrosine phosphorylation and stress fiber turnover.
  • 基因功能参考文献：
    1. Data indicate that the structural elements in MRDI distal from the MTR-1-P catalytic site are responsible for the invasion phenotype. PMID: 23859498
    2. Identification of MRI1, encoding translation initiation factor eIF-2B subunit alpha/beta/delta-like protein, as a candidate locus for infantile epilepsy with severe cystic degeneration of the brain. PMID: 23124037
  • 亚细胞定位：
    Nucleus. Cytoplasm. Cell projection. Note=Primarily nuclear, but cytoplasmic in cancer cells, with enrichment at leading edge of the plasma membrane in late stage tumor cells.
  • 蛋白家族：
    EIF-2B alpha/beta/delta subunits family, MtnA subfamily
  • 数据库链接：

    HGNC: 28469

    OMIM: 615105

    KEGG: hsa:84245

    STRING: 9606.ENSP00000040663

    UniGene: Hs.439370