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  4. Recombinant Human Migration and invasion-inhibitory protein (MIIP)

Recombinant Human Migration and invasion-inhibitory protein (MIIP)

  • 中文名称：
    人MIIP重组蛋白
  • 货号：
    CSB-YP686389HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人MIIP重组蛋白
  • 货号：
    CSB-EP686389HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人MIIP重组蛋白
  • 货号：
    CSB-EP686389HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人MIIP重组蛋白
  • 货号：
    CSB-BP686389HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人MIIP重组蛋白
  • 货号：
    CSB-MP686389HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    MIIP
  • Uniprot No.：
  • 别名：
    MIIP; IIP45; Migration and invasion-inhibitory protein; IGFBP2-binding protein; Invasion-inhibitory protein 45; IIp45
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-388
  • 氨基酸序列
    MVEAEELAQL RLLNLELLRQ LWVGQDAVRR SVARAASESS LESSSSYNSE TPSTPETSST SLSTSCPRGR SSVWGPPDAC RGDLRDVARS GVASLPPAKC QHQESLGRPR PHSAPSLGTS SLRDPEPSGR LGDPGPQEAQ TPRSILAQQS KLSKPRVTFS EESAVPKRSW RLRPYLGYDW IAGSLDTSSS ITSQPEAFFS KLQEFRETNK EECICSHPEP QLPGLRESSG SGVEEDHECV YCYRVNRRLF PVPVDPGTPC RLCRTPRDQQ GPGTLAQPAH VRVSIPLSIL EPPHRYHIHR RKSFDASDTL ALPRHCLLGW DIFPPKSEKS SAPRNLDLWS SVSAEAQHQK LSGTSSPFHP ASPMQMLPPT PTWSVPQVPR PHVPRQKP
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Inhibits glioma cells invasion and down-regulates adhesion- and motility-associated genes such as NFKB2 and ICAM1. Exhibits opposing effects to IGFBP2 on cell invasion.
  • 基因功能参考文献：
    1. Data show that protein kinase C epsilon (PKCepsilon) phosphorylates migration and invasion inhibitory protein (MIIP) at Ser303 and promotes its binding to RelA/p65, facilitating colorectal cancer metastasis. PMID: 29038521
    2. MIIP may function as a tumor suppressor gene for endometrial carcinoma. MIIP attenuates Rac1 signaling through a protein interaction network, and loss of this regulator may contribute to EC metastasis. PMID: 27760566
    3. MIIP haploinsufficiency induces chromosomal instability and promotes tumour progression in colorectal cancer. PMID: 27741356
    4. MIIP expression in esophageal squamous-cell carcinoma tissues was increased significantly in comparison with the paired paracancerous normal epithelia and was associated with cell differentiation. Patients with low MIIP expression had improved overall and disease-free survival. MIIP expression was an independent prognostic factor in ESCC OS and DFS. PMID: 26825982
    5. MIIP attenuates mitotic transition and increases mitotic catastrophe, thereby inhibiting glioma development and progression. PMID: 20418911
    6. Data show a novel mechanism by which IIp45 inhibits cell motility through inhibition of HDAC6. PMID: 20008322
    7. Results suggest MIIP K167E as a functional genetic marker of breast cancer development and prognosis. PMID: 20103646
    8. identified a gene, invasion inhibitory protein 45 (IIp45), whose protein product bound to IGFBP-2 through the thyroglobulin-RGD region of the C terminus of IGFBP-2 PMID: 14617774
    9. IIp45 gene is inactivated by a tumor-specific alternative splicing that generates an aberrant and unstable IIp45 isoform in infiltrative gliomas. PMID: 15867349

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  • 组织特异性：
    Ubiquitous. Isoform 1 is expressed in brain but underexpressed in glioma tissues, at protein level. Isoform 2 is not detected in normal organs, but is expressed in gliomas with increasing levels with glioma progression. On the contrary, at protein level,
  • 数据库链接：

    HGNC: 25715

    OMIM: 608772

    KEGG: hsa:60672

    STRING: 9606.ENSP00000235332

    UniGene: Hs.8595