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  4. Recombinant Human Mitochondrial dynamic protein MID49 (SMCR7), partial

Recombinant Human Mitochondrial dynamic protein MID49 (SMCR7), partial

  • 中文名称：
    人MIEF2重组蛋白
  • 货号：
    CSB-YP842646HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人MIEF2重组蛋白
  • 货号：
    CSB-EP842646HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人MIEF2重组蛋白
  • 货号：
    CSB-EP842646HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人MIEF2重组蛋白
  • 货号：
    CSB-BP842646HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人MIEF2重组蛋白
  • 货号：
    CSB-MP842646HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    MIEF2
  • Uniprot No.：
  • 别名：
    MGC23130; MID49; MID49_HUMAN; MIEF2; Mitochondrial dynamic protein MID49; Mitochondrial dynamic protein of 49 kDa; Mitochondrial dynamics protein MID49; Mitochondrial dynamics protein of 49 kDa; Mitochondrial elongation factor 2; Smith Magenis syndrome chromosome region candidate 7; Smith-Magenis syndrome chromosomal region candidate gene 7 protein
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Mitochondrial outer membrane protein involved in the regulation of mitochondrial organization. It is required for mitochondrial fission and promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface independently of the mitochondrial fission FIS1 and MFF proteins. Regulates DNM1L GTPase activity.
  • 基因功能参考文献：
    1. cryo-electron microscopy structure of full-length human DRP1 co-assembled with MID49 and an analysis of structure- and disease-based mutations PMID: 29899447
    2. Knockdown of MIEF2 reduces DOX-induced mitochondrial fission and apoptosis in cardiomyocytes and in vivo. Also, knockdown of MIEF2 protects heart from DOX-induced cardiotoxicity. Our study identifies a novel pathway composed of Foxo3a and MIEF2 that mediates DOX cardiotoxicity. PMID: 28137654
    3. MiD49 and MiD51 recruit inactive forms of Drp1 in mitochondrial fission. [review] PMID: 27660309
    4. we find that either MiD49 or MiD51 can mediate Drp1 recruitment and mitochondrial fission in the absence of Fis1 and Mff. PMID: 23283981
    5. Smith-Magenis syndrome is caused by a de novo deletion on chromosome 17. PMID: 15517828

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  • 亚细胞定位：
    Mitochondrion outer membrane; Single-pass membrane protein. Note=Colocalizes with DNM1L at mitochondrial membrane. Forms foci and rings around mitochondria.
  • 蛋白家族：
    MID49/MID51 family
  • 组织特异性：
    Expressed in all tissues tested with highest expression in heart and skeletal muscle.
  • 数据库链接：

    HGNC: 17920

    OMIM: 615498

    KEGG: hsa:125170

    STRING: 9606.ENSP00000379057

    UniGene: Hs.655555