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  4. Recombinant Human Mitochondrial ubiquitin ligase activator of NFKB 1 (MUL1), partial

Recombinant Human Mitochondrial ubiquitin ligase activator of NFKB 1 (MUL1), partial

  • 中文名称：
    人MUL1重组蛋白
  • 货号：
    CSB-YP839281HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人MUL1重组蛋白
  • 货号：
    CSB-EP839281HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人MUL1重组蛋白
  • 货号：
    CSB-EP839281HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人MUL1重组蛋白
  • 货号：
    CSB-BP839281HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人MUL1重组蛋白
  • 货号：
    CSB-MP839281HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    MUL1
  • Uniprot No.：
  • 别名：
    0610009K11Rik; AV000801; C1orf166; Chromosome 1 open reading frame 166; E3 SUMO-protein ligase MUL1; E3 ubiquitin ligase; E3 ubiquitin protein ligase MUL1; E3 ubiquitin-protein ligase MUL1; FLJ12875; GIDE; Growth inhibition and death E3 ligase; MAPL; Mitochondrial anchored protein ligase; mitochondrial E3 ubiquitin ligase 1; mitochondrial E3 ubiquitin protein ligase 1; Mitochondrial ubiquitin ligase activator of NFKB 1; Mitochondrial-anchored protein ligase; MUL1; MUL1_HUMAN; MULAN; Putative NF kappa B activating protein 266; Putative NF-kappa-B-activating protein 266; RGD1309944; RING finger protein 218; RNF218; RP11-401M16.2; RP23-25C1.10-002
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Exhibits weak E3 ubiquitin-protein ligase activity. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. Can ubiquitinate AKT1 preferentially at 'Lys-284' involving 'Lys-48'-linked polyubiquitination and seems to be involved in regulation of Akt signaling by targeting phosphorylated Akt to proteosomal degradation. Mediates polyubiquitination of cytoplasmic TP53 at 'Lys-24' which targets TP53 for proteasomal degradation, thus reducing TP53 levels in the cytoplasm and mitochondrion. Proposed to preferentially act as a SUMO E3 ligase at physiological concentrations. Plays a role in the control of mitochondrial morphology by promoting mitochondrial fragmentation, and influences mitochondrial localization. Likely to promote mitochondrial fission through negatively regulating the mitochondrial fusion proteins MFN1 and MFN2, acting in a pathway that is parallel to the PRKN/PINK1 regulatory pathway. May also be involved in the sumoylation of the membrane fission protein DNM1L. Inhibits cell growth. When overexpressed, activates JNK through MAP3K7/TAK1 and induces caspase-dependent apoptosis. Involved in the modulation of innate immune defense against viruses by inhibiting DDX58-dependent antiviral response. Can mediate DDX58 sumoylation and disrupt its polyubiquitination.
  • 基因功能参考文献：
    1. Data demonstrate a clear role for MAPL and mitochondrial SUMOylation in the activation of RIG-I, a modification essential for the mitochondrial antiviral signaling response. PMID: 28273895
    2. MULAN regulates NF-kappaappaB activation to protect cells from endoplasmic reticulum stress-induced apoptosis. PMID: 27082251
    3. MUL1 ubiquitinates ULK1 and regulates selenite-induced mitophagy PMID: 26018823
    4. Cigarette smoke-induced MUL1 elevation mediates Akt ubiquitination/degradation, potentially leading to pulmonary endothelial cell death and functional impairment. PMID: 26203915
    5. Hades (MUL1)-mediated p73 ubiquitination is a novel regulatory mechanism for the exonuclear function of p73. PMID: 26435500
    6. Activation of apoptosis triggers MAPL/MUL1-dependent SUMOylation of the fission GTPase Drp1, a process requisite for cytochrome c release. PMID: 26384664
    7. The interaction of GABARAP with Mulan-Ube2E3 supports the role of Mulan as an important regulator of mitophagy. PMID: 25224329
    8. MethyLight data demonstrated that C13orf18 and C1orf166 could not be considered as specific, sensitive and suitable prognostic biomarkers in cervical dysplasia related Papillomavirus Infections. PMID: 25169519
    9. During stress-induced mitochondrial hyperfusion, MULAN forms a complex with TRAF2 and modulates its ubiquitylation, signifying that TRAF2 may serve as an ubiquitylated transmitter of NF-kappaB signaling in this pathway PMID: 24841215
    10. MUL1 is a novel regulator of the RIG-I-like receptor-dependent antiviral response, that otherwise functions to limit inflammation. PMID: 23399697
    11. MULAN negatively regulates Akt signaling, facilitating the control of multiple cellular processes. PMID: 22410793
    12. These findings show that Hades (MUL1)-mediated p53 ubiquitination is a novel mechanism for negatively regulating the exonuclear function of p53 PMID: 21597459
    13. CARP and its regulator calpain 3 appear to occupy a central position in the important cell fate-governing NF-kappaB pathway in skeletal muscle PMID: 20860623
    14. incorporated within unique, DRP1-independent, 70-100 nm diameter mitochondria-derived vesicles which fuse with a subset of peroxisomes PMID: 18207745
    15. findings suggest the existence of a new, Ub-mediated mechanism responsible for integration of mitochondria into the cellular environment PMID: 18213395
    16. The identification of GIDE, a mitochondrially located E3 ubiquitin ligase, is reported. PMID: 18591963
    17. The mitochondrial-anchored protein ligase (MAPL) is characterized as the first mitochondrial-anchored SUMO E3 ligase. PMID: 19407830
    18. Confocal- and electron-microscopy studies of MAPL-YFP led to the observation that mitochondria-anchored protein ligase (MAPL) is incorporated within unique, DRP1-independent, 70-100 nm diameter mitochondria-derived vesicles (MDVs). PMID: 18207745
    19. MULAN (Mitochondrial Ubiquitin Ligase Activator of NF-kB; aka FLJ12875, C1orf166) is a RING finger-type E3 ubiquitin ligase anchored to mitochondria that has been implicated in the regulation of mitochondrial dynamics and in the activation of NF-kB. PMID: 18213395

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  • 亚细胞定位：
    Mitochondrion outer membrane; Multi-pass membrane protein. Peroxisome.
  • 组织特异性：
    Widely expressed with highest levels in the heart, skeletal muscle, placenta, kidney and liver. Barely detectable in colon and thymus.
  • 数据库链接：

    HGNC: 25762

    OMIM: 612037

    KEGG: hsa:79594

    STRING: 9606.ENSP00000264198

    UniGene: Hs.10101