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  4. Recombinant Human Motor neuron and pancreas homeobox protein 1 (MNX1)

Recombinant Human Motor neuron and pancreas homeobox protein 1 (MNX1)

  • 中文名称：
    人MNX1重组蛋白
  • 货号：
    CSB-YP014692HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人MNX1重组蛋白
  • 货号：
    CSB-EP014692HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人MNX1重组蛋白
  • 货号：
    CSB-EP014692HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人MNX1重组蛋白
  • 货号：
    CSB-BP014692HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人MNX1重组蛋白
  • 货号：
    CSB-MP014692HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    MNX1
  • Uniprot No.：
  • 别名：
    HB 9; HB9; HLXB 9; HLXB9; Homeo box HB9; Homeobox HB9; Homeobox protein HB9; HOXHB9; MNX1; MNX1_HUMAN; Motor neuron and pancreas homeobox 1; Motor neuron and pancreas homeobox protein 1; Sacral agenesis autosomal dominant (Currarino triad); SCRA 1; SCRA1
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-401
  • 氨基酸序列
    MEKSKNFRID ALLAVDPPRA ASAQSAPLAL VTSLAAAASG TGGGGGGGGA SGGTSGSCSP ASSEPPAAPA DRLRAESPSP PRLLAAHCAL LPKPGFLGAG GGGGGTGGGH GGPHHHAHPG AAAAAAAAAA AAAAGGLALG LHPGGAQGGA GLPAQAALYG HPVYGYSAAA AAAALAGQHP ALSYSYPQVQ GAHPAHPADP IKLGAGTFQL DQWLRASTAG MILPKMPDFN SQAQSNLLGK CRRPRTAFTS QQLLELEHQF KLNKYLSRPK RFEVATSLML TETQVKIWFQ NRRMKWKRSK KAKEQAAQEA EKQKGGGGGA GKGGAEEPGA EELLGPPAPG DKGSGRRLRD LRDSDPEEDE DEDDEDHFPY SNGASVHAAS SDCSSEDDSP PPRPSHQPAP Q
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Putative transcription factor involved in pancreas development and function.
  • 基因功能参考文献：
    1. MNX1 may directly regulate TrkB expression, which may increase their metastatic potential via suppression of anoikis and enhanced adhesion to the ECM. PMID: 30066929
    2. Pathogenic variants in MNX1 were detected in 28% of all CS cases and 25% of sporadic cases. The clinical phenotype was variable in patients with and without pathogenic variants; no significant genotype-phenotype correlation was observed. PMID: 29401559
    3. Findings identify RGS12 as a candidate tumor-suppressor gene in AA prostate cancer, which acts by decreasing expression of AKT and MNX1, establishing a novel oncogenic axis in this disparate disease setting. PMID: 28611045
    4. MNX1 as a novel targetable oncogene increased in African-American (AA) prostate cancer that is associated with aggressive disease. PMID: 27578002
    5. Findings demonstrated for the first time that lncRNA MNX1-AS1 functions as an oncogene in ovarian cancer. PMID: 28414551
    6. The results illustrated miR-200a and miR-141 could inhibit the expression of Hlxb9 by binding to its mRNA 3'UTR. Furthermore, the expression of miR-200a and miR-141 was almost reciprocal to that of Hlxb9. Overexpression of miR-200a and miR-141 downregulated the expression of pancreatic progenitor cell markers Hlxb9 PMID: 26801823
    7. The nuclear positioning of the HLXB9 gene was monitored at different stages. PMID: 25136833
    8. study reports the results of MNX1 mutational screening in a series of 28 cases suspected having Currarino Syndrome and characterization of 10 novel mutations PMID: 24095820
    9. NKX2-2 and MNX1 are etiological genes for neonatal diabetes. PMID: 24411943
    10. Both pHLXB9 and active GSK-3beta are elevated in beta cells with menin knockdown, in MEN1-associated beta cell tumors (insulinomas) PMID: 24425879
    11. study describes a Norwegian family with typical Currarino syndrome in which a heterozygous deletion removes the entire MNX1 gene but no other known genes; also report MNX1 mutations in 3other Norwegian families and confirm that the GCC12 repeat (c.373_375[12]) is a normal allelic variant PMID: 23370340
    12. HB9 binds to the prostaglandin E receptor 2 promoter and inhibits intracellular cAMP mobilization in leukemic cells. PMID: 23048027
    13. a new HLXB9 gene mutation identified in a Chinese family with members suffering from Currarino syndrome PMID: 21960426
    14. two novel mutations in the MNX1 gene in cases with Currarino syndrome PMID: 22820079
    15. 2 previously described mutations, 1 de novo nonsense mutation (p.Gln212X) & 1 maternally inherited frameshift mutation (p.Pro18ProfsX38)were found among 14 Currarino syndrome patients with presacral tumors. PMID: 21763840
    16. Hypermethylation of HLXB9 results in loss of expression and is associated with acute lymphoblastic leukemia. PMID: 21069786
    17. HLXB9 is overexpressed in patients with infantile acute myeloid leukemia. PMID: 19446746
    18. Incomeplete Curarino syndrome with more advantageous prognosis with autosomal domiant pattern homebox gene HLXBV9 mutation. PMID: 20146075
    19. study reports on the MNX1 mutations in a family segregating Currarino syndrome (CS) & 3 sporadic CS patients & on clinical characteristics of the affected individuals PMID: 19853743
    20. mutation in the HLXB9 transcription factor causes an autosomal dominant form of sacral agenesis PMID: 11940082
    21. The chromosomal rearrangements of the HLXB9 protein locus at 7q36 were not detected in Hodgkin lymphoma cells unlike acute myeloid leukemia subsets expressing HLXB9. PMID: 15772702
    22. High incidence of t(7;12)(q36;p13) in infant myeloid leukemia is associated with ectopic expression of HLXB9. PMID: 16646086
    23. This study confirms that familial Currarino syndrome (CS) patients in Korea have the same genetic background as other ethnicities and reaffirms the phenotype variability among CS patients with the same mutation. PMID: 17612791
    24. report 23 novel mutations in 26 patients among a series of 50 index cases with Currarino syndrome PMID: 18449898
    25. MNX1-ETV6 fusion gene in an acute megakaryoblastic leukemia. PMID: 18940475
    26. Ectopic expression of the HLXB9 gene is associated with an altered nuclear position in t(7;12) leukaemias PMID: 19212340

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  • 相关疾病：
    Currarino syndrome (CURRAS)
  • 亚细胞定位：
    Nucleus.
  • 组织特异性：
    Expressed in lymphoid and pancreatic tissues.
  • 数据库链接：

    HGNC: 4979

    OMIM: 142994

    KEGG: hsa:3110

    STRING: 9606.ENSP00000252971

    UniGene: Hs.37035