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  4. Recombinant Human Myc target protein 1 (MYCT1)

Recombinant Human Myc target protein 1 (MYCT1)

  • 中文名称：
    人MYCT1重组蛋白
  • 货号：
    CSB-YP839809HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人MYCT1重组蛋白
  • 货号：
    CSB-EP839809HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人MYCT1重组蛋白
  • 货号：
    CSB-EP839809HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人MYCT1重组蛋白
  • 货号：
    CSB-BP839809HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人MYCT1重组蛋白
  • 货号：
    CSB-MP839809HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    MYCT1
  • Uniprot No.：
  • 别名：
    1110020B04Rik; AI225941; AI642973; FLJ21269; MGC156309; MGC156310; MTLC; Mtmc1; Myc target 1; Myc target in myeloid cells protein 1; Myc target protein 1; Myct1; MYCT1_HUMAN
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-235
  • 氨基酸序列
    MRTQVYEGLC KNYFSLAVLQ RDRIKLLFFD ILVFLSVFLL FLLFLVDIMA NNTTSLGSPW PENFWEDLIM SFTVSMAIGL VLGGFIWAVF ICLSRRRRAS APISQWSSSR RSRSSYTHGL NRTGFYRHSG CERRSNLSLA SLTFQRQASL EQANSFPRKS SFRASTFHPF LQCPPLPVET ESQLVTLPSS NISPTISTSH SLSRPDYWSS NSLRVGLSTP PPPAYESIIK AFPDS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May regulate certain MYC target genes, MYC seems to be a direct upstream transcriptional activator. Does not seem to significantly affect growth cell capacity. Overexpression seems to mediate many of the known phenotypic features associated with MYC, including promotion of apoptosis, alteration of morphology, enhancement of anchorage-independent growth, tumorigenic conversion, promotion of genomic instability, and inhibition of hematopoietic differentiation.
  • 基因功能参考文献：
    1. YY1 promotes proliferation and migration with suppression of apoptosis via directly inhibiting MYCT1 in laryngeal cancer cells, suggesting that YY1 is a useful target as a potential oncogene in laryngeal cancer development and progression. PMID: 28485541
    2. Overexpression of MYCT1, decreased cell viability under serum deprivation and increased tumour cell migration ability. PMID: 26710964
    3. this study has provided the theoretical basis for the further discussion of the effect and mechanism of action of MTLC in the occurrence of laryngeal cancer. PMID: 27072211
    4. Data indicate 3 variants in 3 novel genes myc target 1 protein (MYCT1), caspase recruitment domain family member 8 (CARD8) and zinc finger protein 543 (ZNF543), associated with familial IgA nephropathy (IgAN). PMID: 26095808
    5. hypermethylation contributed to the transcriptional down-regulation of MYCT1 and could inhibit cancer cell differentiation in laryngeal squamous cell cancer. PMID: 22672838
    6. results suggest MYCT1 transcription can be activated downstream of RUNX1-ETO as well as MYC, contributing to key aspects of the leukaemic phenotypes these oncoproteins promote PMID: 21799513
    7. MYCT1-TV, a novel MYCT1 transcript, is regulated by c-Myc and down-regulation of MYCT1-TV/MYCT1 could contribute to LSCC development and function PMID: 21998677
    8. MTLC was down-regulated in the majority of gastric cancer tissues and could promote apoptosis of GC cell lines, which suggests that MTLC may play an important role in the carcinogenesis of gastric carcinoma. PMID: 14562369

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  • 亚细胞定位：
    Nucleus. Note=Expressed in nuclei of hepatocellular carcinoma cell line BEL-7402 cells.
  • 蛋白家族：
    MYCT1 family
  • 组织特异性：
    Down-regulated in gastric cancer tissues.
  • 数据库链接：

    HGNC: 23172

    KEGG: hsa:80177

    STRING: 9606.ENSP00000356214

    UniGene: Hs.18160