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  4. Recombinant Human Myosin light chain 4 (MYL4)

Recombinant Human Myosin light chain 4 (MYL4)

  • 中文名称：
    人MYL4重组蛋白
  • 货号：
    CSB-YP015311HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人MYL4重组蛋白
  • 货号：
    CSB-EP015311HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人MYL4重组蛋白
  • 货号：
    CSB-EP015311HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人MYL4重组蛋白
  • 货号：
    CSB-BP015311HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人MYL4重组蛋白
  • 货号：
    CSB-MP015311HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    ALC 1; ALC1; AMLC; Atrial/embryonic alkali myosin light chain; embryonic muscle/atrial isoform; GT 1; GT1; MLC 1; MLC1; MYL 4; Myl4; MYL4_HUMAN; Myosin atrial/fetal muscle light chain; Myosin light chain 1; Myosin light chain 1 embryonic muscle/atrial isoform; Myosin light chain 4 alkali atrial embryonic; Myosin light chain 4; Myosin light chain alkali GT 1 isoform; Myosin light chain alkali GT-1 isoform; Myosin light polypeptide 4 alkali atrial embryonic; Myosin light polypeptide 4; PRO1957
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-197
  • 氨基酸序列
    MAPKKPEPKK EAAKPAPAPA PAPAPAPAPA PEAPKEPAFD PKSVKIDFTA DQIEEFKEAF SLFDRTPTGE MKITYGQCGD VLRALGQNPT NAEVLRVLGK PKPEEMNVKM LDFETFLPIL QHISRNKEQG TYEDFVEGLR VFDKESNGTV MGAELRHVLA TLGEKMTEAE VEQLLAGQED ANGCINYEAF VKHIMSG
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Regulatory light chain of myosin. Does not bind calcium.
  • 基因功能参考文献：
    1. The s describe in a population approach a loss of function mutation in the myosin gene MYL4 that, in the homozygous state, is completely penetrant for early-onset AF. The finding may provide novel mechanistic insight into the pathophysiology of this complex arrhythmia. PMID: 27742809
    2. a novel, heterozygous p.Glu11Lys mutation in the atrial-specific myosin light chain gene MYL4, caused atrial fibrillation. PMID: 27066836
    3. A recessive frameshift mutation in MYL4 causes early-onset atrial fibrillation. PMID: 25807286
    4. results demonstrate that the expression of hALC-1 could have a beneficial effect on the overloaded hypertrophied heart PMID: 16106982
    5. The (Ala-Pro) rich part of this protein acts as a "spacer arm" responsible for correct positioning of the N-terminal actin binding site. PMID: 9000508
    6. The N-terminus of this protein is an actin binding site. PMID: 9738905
    7. NMR showed involvement of N-terminus and lysines 3 and 4 in interaction with actin. Mutations of these lysines (K3A,K4R,K4A,K4D) resulted in altered actin binding and actin activated MgATPase. Mutation of Ala-1 to val had no effect on binding or kinetics. PMID: 10373429

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  • 相关疾病：
    Atrial fibrillation, familial, 18 (ATFB18)
  • 数据库链接：

    HGNC: 7585

    OMIM: 160770

    KEGG: hsa:4635

    STRING: 9606.ENSP00000347055

    UniGene: Hs.463300