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  4. Recombinant Human N-alpha-acetyltransferase 40 (NAA40)

Recombinant Human N-alpha-acetyltransferase 40 (NAA40)

  • 货号：
    CSB-YP774810HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP774810HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP774810HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP774810HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP774810HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    NAA40
  • Uniprot No.：
  • 别名：
    N acetyltransferase 11 (GCN5 related, putative); N alpha acetyl transferase 40; N alpha acetyltransferase 40; N(alpha) acetyltransferase 40; N(alpha) acetyltransferase 40, NatD catalytic subunit, homolog; N(alpha)-acetyltransferase 40, NatD catalytic subunit, homolog (S. cerevisiae); N-acetyltransferase 11; N-alpha-acetyltransferase 40, NatD catalytic subunit; naa40; NAA40_HUMAN; NAT11; NatD catalytic subunit; PATT1
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-237
  • 氨基酸序列
    GRKSSKAKE KKQKRLEERA AMDAVCAKVD AANRLGDPLE AFPVFKKYDR NGLNVSIECK RVSGLEPATV DWAFDLTKTN MQTMYEQSEW GWKDREKREE MTDDRAWYLI AWENSSVPVA FSHFRFDVEC GDEVLYCYEV QLESKVRRKG LGKFLIQILQ LMANSTQMKK VMLTVFKHNH GAYQFFREAL QFEIDDSSPS MSGCCGEDCS YEILSRRTKF GDSHHSHAGG HCGGCCH
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    N-alpha-acetyltransferase that specifically mediates the acetylation of the N-terminal residues of histones H4 and H2A. In contrast to other N-alpha-acetyltransferase, has a very specific selectivity for histones H4 and H2A N-terminus and specifically recognizes the 'Ser-Gly-Arg-Gly sequence'. Acts as a negative regulator of apoptosis. May play a role in hepatic lipid metabolism.
  • 基因功能参考文献：
    1. NatD-mediated acetylation of histone H4 serine 1 competes with phosphorylation by CK2alpha at the same residue, leading to the upregulation of Slug and lung cancer progression. PMID: 29030587
    2. findings reveal an anti-apoptotic role for Naa40 and exhibit its potential as a therapeutic target in colorectal cancers. PMID: 26666750
    3. The knowledge of detailed molecular architecture of Patt1 is not only the key to understanding its mechanistic functional properties but it also opens the possibility of rational drug and protein design experiments PMID: 24248912
    4. Results strongly suggest that human Naa40p/NatD is conserved from yeast. Thus, the NATs of all classes of N-terminally acetylated proteins in humans now appear to be accounted for. PMID: 21935442
    5. a novel protein acetyltransferase Patt1 might be involved in the development of hepatocellular carcinoma PMID: 19695338

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  • 亚细胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    Acetyltransferase family, NAA40 subfamily
  • 组织特异性：
    Widely expressed; with the highest expression level in liver and the lowest expression in brain (at protein level).
  • 数据库链接：

    HGNC: 25845

    KEGG: hsa:79829

    STRING: 9606.ENSP00000367024

    UniGene: Hs.523753