Your Good Partner in Biology Research

  1. 首页
  2. 蛋白
  3. 重组蛋白
  4. Recombinant Human NF-kappa-B-activating protein (NKAP)

Recombinant Human NF-kappa-B-activating protein (NKAP)

  • 中文名称：
    人NKAP重组蛋白
  • 货号：
    CSB-YP847637HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人NKAP重组蛋白
  • 货号：
    CSB-EP847637HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人NKAP重组蛋白
  • 货号：
    CSB-EP847637HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人NKAP重组蛋白
  • 货号：
    CSB-BP847637HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人NKAP重组蛋白
  • 货号：
    CSB-MP847637HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    NKAP
  • Uniprot No.：
  • 别名：
    NF-kappa-B-activating protein; NFKB activating protein; Nkap; NKAP_HUMAN; Nuclear NF kappaB activating protein
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-415
  • 氨基酸序列
    MAPVSGSRSP DREASGSGGR RRSSSKSPKP SKSARSPRGR RSRSHSCSRS GDRNGLTHQL GGLSQGSRNQ SYRSRSRSRS RERPSAPRGI PFASASSSVY YGSYSRPYGS DKPWPSLLDK EREESLRQKR LSERERIGEL GAPEVWGLSP KNPEPDSDEH TPVEDEEPKK STTSASTSEE EKKKKSSRSK ERSKKRRKKK SSKRKHKKYS EDSDSDSDSE TDSSDEDNKR RAKKAKKKEK KKKHRSKKYK KKRSKKSRKE SSDSSSKESQ EEFLENPWKD RTKAEEPSDL IGPEAPKTLT SQDDKPLNYG HALLPGEGAA MAEYVKAGKR IPRRGEIGLT SEEIASFECS GYVMSGSRHR RMEAVRLRKE NQIYSADEKR ALASFNQEER RKRENKILAS FREMVYRKTK GKDDK
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Acts as a transcriptional repressor. Plays a role as a transcriptional corepressor of the Notch-mediated signaling required for T-cell development. Also involved in the TNF and IL-1 induced NF-kappa-B activation. Associates with chromatin at the Notch-regulated SKP2 promoter.
  • 基因功能参考文献：
    1. SUMOylated NKAP is essential for chromosome alignment by anchoring CENP-E to kinetochores PMID: 27694884
    2. NKAP is required for T cell maturation and the acquisition of functional competency PMID: 21624937
    3. NKAP is a novel nuclear regulator of TNF- and IL-1-induced NF-kappaB activation PMID: 14550261
    4. NKAP functions as a transcriptional repressor, acting on Notch target genes, and is required for alphabeta T cell development. PMID: 19409814
  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    NKAP family
  • 数据库链接：

    HGNC: 29873

    OMIM: 300766

    KEGG: hsa:79576

    STRING: 9606.ENSP00000360464

    UniGene: Hs.522771