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  4. Recombinant Human NKG2-C type II integral membrane protein (KLRC2), partial

Recombinant Human NKG2-C type II integral membrane protein (KLRC2), partial

In Stock
  • 货号：
    CSB-EP012467HU
  • 规格：
    ￥1344
  • 图片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

产品详情

  • 纯度：
    Greater than 90% as determined by SDS-PAGE.
  • 基因名：
  • Uniprot No.：
  • 别名：
    CD antigen CD159c; CD159 antigen like family member C; CD159 antigen-like family member C; CD159c; Killer cell lectin like receptor subfamily C, member 2; KLRC2; NK cell receptor C; NKG2-C type II integral membrane protein; NKG2-C-activating NK receptor; NKG2C activating NK receptor; NKG2C; NKG2C_HUMAN
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Extracellular Domain
  • 来源：
    E.coli
  • 分子量：
    31.8kDa
  • 表达区域：
    94-231aa
  • 氨基酸序列
    IPFLEQNNSSPNTRTQKARHCGHCPEEWITYSNSCYYIGKERRTWEESLLACTSKNSSLLSIDNEEEMKFLASILPSSWIGVFRNSSHHPWVTINGLAFKHKIKDSDNAELNCAVLQVNRLKSAQCGSSMIYHCKHKL
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 6xHis-SUMO-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Tris-based buffer,50% glycerol
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    3-7 business days
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Immune activating receptor involved in self-nonself discrimination. In complex with KLRD1 on cytotoxic lymphocyte subsets, recognizes non-classical major histocompatibility (MHC) class Ib HLA-E loaded with signal sequence-derived peptides from non-classical MHC class Ib HLA-G molecules, likely playing a role in the generation and effector functions of adaptive natural killer (NK) cells and in maternal-fetal tolerance during pregnancy. Regulates the effector functions of terminally differentiated cytotoxic lymphocyte subsets, and in particular may play a role in adaptive NK cell response to viral infection. Upon HLA-E-peptide binding, transmits intracellular signals via the adapter protein TYROBP/DAP12, triggering the phosphorylation of proximal signaling molecules and cell activation.
  • 基因功能参考文献：
    1. a 16kb deletion encompassing the NKG2C gene is associated with lower carotid intimal media thickness values and higher humoral and T-cell responses to cytomegalovirus in renal transplant recipients PMID: 28987961
    2. the data of this study extend the characterization of adaptive NK cell subsets that differentiate in response to human Cytomegalovirus, supporting a relationship between their distribution and NKG2C copy number PMID: 26994220
    3. The new method offers the potential to use SNP arrays from genome wide association studies to study the frequency of KLRC2 deletion in other populations and its association with other diseases PMID: 27312142
    4. Assessment of NK cell repertoires in 60 NKG2C(-/-) donors revealed a broad range of NK cell populations displaying characteristic footprints of adaptive NK cells, including a terminally differentiated phenotype, functional reprogramming, and epigenetic remodeling of the interferon (IFN)-gamma promoter. PMID: 27117418
    5. HLA-E regulates NKG2C+ natural killer cell function through presentation of a restricted peptide repertoire PMID: 26382247
    6. genetic polymorphism is not associated with nasopharyngeal carcinoma in China PMID: 25636564
    7. Data suggest the proinflammatory potential of NKG2C(bright) NK cells. PMID: 25667418
    8. lack of expression of NKG2C may be associated with altered control of human cytomegalovirus infection in childhood PMID: 25150297
    9. No difference in the prevalence of NKG2C deletion was observed. PMID: 24305414
    10. NKG2C receptor deletion and a functional polymorphism in its ligand HLA-E may play a role in psoriasis susceptibility PMID: 24079744
    11. NKG2C(hi)CD57+ NK cells respond specifically to acute infection with cytomegalovirus and not Epstein-Barr virus. PMID: 24740502
    12. NKG2Cnull does not seem to constitute a risk factor for HPV-induced cervical lesions. PMID: 23911737
    13. NKG2C zygosity influences CD94/NKG2C receptor function and the NK-cell compartment redistribution in response to human cytomegalovirus. PMID: 24030638
    14. coexpression of killer cell Ig-like receptor (KIR) and NKG2C on expanded NK cell subsets could be related to a functional contribution of KIR in cytomegalovirus infection PMID: 23918974
    15. NKG2Chi CD57hi natural killer cells are highly responsive to human cytomegalovirus-infected macrophages only in the presence of HCMV-specific antibodies, whereas they are functionally poor effectors of natural cytotoxicity. PMID: 23637420
    16. The increased expression of NKG2C in HIV patients indicate that NKG2C is important in the defense against HIV infection and progression. PMID: 22074011
    17. A significantly elevated proportion of ex vivo peripheral blood CD4 T cells, but not CD8 T cells or natural killer (NK) cells, from multiple sclerosis patients express NKG2C, which contributes to tissue injury. PMID: 23396942
    18. HCMV-infected NKG2C(+/+) children displayed higher absolute numbers of NKG2A(+) and total NK cells than NKG2C(+/-) individuals. PMID: 22965785
    19. expression by Vdelta2+ T cells is lower in pregnant women PMID: 19395088
    20. CD94/NKG2C might be involved in triggering cytotoxic lymphocytes in patients with Toxic epidermal necrolysis and Stevens-Johnson syndrome PMID: 20132973
    21. Common occurrence of NKG2-C gene deletion in the general population. PMID: 12618865
    22. NKG2C is not essential for survival and reproduction, and is not associated with rheumatic diseases PMID: 14688071
    23. strict gene regulatory mechanisms for CD94 and NKG2 gene expression on CD4+ cells PMID: 15550116
    24. CD94/NKG2C may constitute an alternative T cell activation pathway capable of driving the expansion and triggering the effector functions of a cytotoxic T cell subset. PMID: 15940674

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  • 亚细胞定位：
    Cell membrane; Single-pass type II membrane protein.
  • 组织特异性：
    Expressed in NK cell subsets, in particular in adaptive CD57-positive NK cells (at protein level). Expressed in terminally differentiated cytotoxic gamma-delta T cells (at protein level). Expressed in alpha-beta T cells subsets (at protein level). KLRD1-K
  • 数据库链接：

    HGNC: 6375

    OMIM: 602891

    KEGG: hsa:3822

    STRING: 9606.ENSP00000371327

    UniGene: Hs.591157