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  4. Recombinant Human Nanos homolog 3 (NANOS3)

Recombinant Human Nanos homolog 3 (NANOS3)

  • 中文名称：
    人NANOS3重组蛋白
  • 货号：
    CSB-YP015438HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人NANOS3重组蛋白
  • 货号：
    CSB-EP015438HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人NANOS3重组蛋白
  • 货号：
    CSB-EP015438HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人NANOS3重组蛋白
  • 货号：
    CSB-BP015438HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人NANOS3重组蛋白
  • 货号：
    CSB-MP015438HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    NANOS3
  • Uniprot No.：
  • 别名：
    NANO3_HUMAN; Nanos homolog 3; NANOS3; NOS-3; Nos3
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-173
  • 氨基酸序列
    MGTFDLWTDY LGLAHLVRAL SGKEGPETRL SPQPEPEPML EPDQKRSLES SPAPERLCSF CKHNGESRAI YQSHVLKDEA GRVLCPILRD YVCPQCGATR ERAHTRRFCP LTGQGYTSVY SHTTRNSAGK KLVRPDKAKT QDTGHRRGGG GGAGFRGAGK SEPSPSCSPS MST
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Plays a role in the maintenance of the undifferentiated state of germ cells regulating the spermatogonia cell cycle and inducing a prolonged transit in G1 phase. Affects cell proliferation probably by repressing translation of specific mRNAs. Maintains the germ cell lineage by suppressing both Bax-dependent and -independent apoptotic pathways. Essential in the early stage embryo to protect the migrating primordial germ cells (PGCs) from apoptosis.
  • 基因功能参考文献：
    1. despite the prominent role of NANOS3 in ovarian development, our findings suggest that NANOS3 mutations were not associated with POF in the present cohort of Brazilian women. PMID: 28076512
    2. data can be used to further elucidate the role of NANOS3 and DAZL in germ cell development both in vitro and in vivo PMID: 27768780
    3. NANOS3 has role in the acquisition of invasiveness by human lung tumour cells and propose a new mechanism of post-transcriptional regulation of epithelial-mesenchymal transition. PMID: 25904364
    4. an inactivating missense mutation in NANOS3 has a role in primary ovarian insufficiency that involves increased primordial germ cell apoptosis during embryonic cell migration PMID: 25054146
    5. NANOS3 mutation is one possible cause of primary ovarian insufficiency. PMID: 24091668
    6. NANOS3 modulates essential aspects of human germ cell development perhaps during the cell cycle. PMID: 21421998
    7. Mutations in NANOS3 exons are rare in both Chinese and Caucasian women with premature ovarian failure. PMID: 17418157
    8. Report for the first time analysis of the NANOS3 gene in infertile males. PMID: 19565640
    9. Observational study of genotype prevalence. (HuGE Navigator) PMID: 17418157

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  • 亚细胞定位：
    Nucleus. Cytoplasm. Cytoplasm, Stress granule. Cytoplasm, P-body.
  • 蛋白家族：
    Nanos family
  • 组织特异性：
    Ovary, testis and brain (at protein level). In the ovaries, expressed during multiple stages of oogenesis, including primordial, primary, secondary and antral follicles with the highest expression in the oocytes. In the testis, expressed in germ cells, ty
  • 数据库链接：

    HGNC: 22048

    OMIM: 608229

    KEGG: hsa:342977

    UniGene: Hs.127982