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  4. Recombinant Human Neurexophilin-1 (NXPH1)

Recombinant Human Neurexophilin-1 (NXPH1)

  • 中文名称：
    人NXPH1重组蛋白
  • 货号：
    CSB-YP016227HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人NXPH1重组蛋白
  • 货号：
    CSB-EP016227HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人NXPH1重组蛋白
  • 货号：
    CSB-EP016227HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人NXPH1重组蛋白
  • 货号：
    CSB-BP016227HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人NXPH1重组蛋白
  • 货号：
    CSB-MP016227HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    NXPH1
  • Uniprot No.：
  • 别名：
    Nbla00697; Neurexophilin 1; Neurexophilin-1; Neurexophilin1; NPH1; NXPH 1; NXPH1; NXPH1_HUMAN
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    22-271
  • 氨基酸序列
    ANLTNGGKS ELLKSGSSKS TLKHIWTESS KDLSISRLLS QTFRGKENDT DLDLRYDTPE PYSEQDLWDW LRNSTDLQEP RPRAKRRPIV KTGKFKKMFG WGDFHSNIKT VKLNLLITGK IVDHGNGTFS VYFRHNSTGQ GNVSVSLVPP TKIVEFDLAQ QTVIDAKDSK SFNCRIEYEK VDKATKNTLC NYDPSKTCYQ EQTQSHVSWL CSKPFKVICI YISFYSTDYK LVQKVCPDYN YHSDTPYFPS G
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May be signaling molecules that resemble neuropeptides and that act by binding to alpha-neurexins and possibly other receptors.
  • 基因功能参考文献：
    1. identification of SNPs within the IQCJ, NXPH1, PHF17 and MYB genes partly explaining the large interindividual variability observed in plasma triglyceride levels in response to an n-3 fatty acid supplementation PMID: 27160456
    2. A genome-wide association study (GWAS) identified loci associated with the plasma triglyceride (TG) response to omega-3 fatty acid (FA) supplementation in IQCJ, NXPH1, PHF17 and MYB. PMID: 28134766
    3. The role of NXPH1 in in paranoid schizophrenia development in Russians. PMID: 26410934
    4. Rs2349775 (NXPH1) and rs17837965 (CDC42) were associated with diarrhoea and constipation predominant irritable bowel syndrome, respectively, in two independent cohorts. PMID: 24041540
    5. Data indicate that median methylation levels of BCAN, HOXD1, KCTD8, KLF11, NXPH1, POU4F1, SIM1, and TCF7L1 were >/=30% higher than in normal samples, representing potential biomarkers for tumor diagnosis. PMID: 22930747
    6. Data indicate taht candidate genes ACTB, BZW, OCM, MACC1, NXPH1, PRPS1L1, RAC1 and RPA3, which lie within the DFNB90 region, were sequenced and no potentially causal variants were identified. PMID: 21734401
    7. results demonstrate the presence and function of a regulated signaling axis in hematopoiesis centered on NRXN1alpha and its modulation by DAG1 and NXPH1 PMID: 21628410
    8. In rat, neurexophilin 1 forms a very tight complex with neurexin I alpha. PMID: 8699246
    9. In rat, the secreted ligand for alpha-neurexin, neurexophilin 1, is expressed in the postnatal olfactory bulb. PMID: 12141453

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Neurexophilin family
  • 数据库链接：

    HGNC: 20693

    OMIM: 604639

    KEGG: hsa:30010

    STRING: 9606.ENSP00000384551

    UniGene: Hs.487564