Recombinant Human Nucleotide exchange factor SIL1 (SIL1)
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中文名称:人SIL1重组蛋白
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货号:CSB-YP875645HU
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规格:
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来源:Yeast
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其他:
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中文名称:人SIL1重组蛋白
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货号:CSB-EP875645HU
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规格:
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来源:E.coli
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其他:
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中文名称:人SIL1重组蛋白
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货号:CSB-EP875645HU-B
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规格:
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来源:E.coli
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共轭:Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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其他:
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中文名称:人SIL1重组蛋白
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货号:CSB-BP875645HU
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规格:
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来源:Baculovirus
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其他:
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中文名称:人SIL1重组蛋白
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货号:CSB-MP875645HU
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规格:
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来源:Mammalian cell
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其他:
产品详情
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纯度:>85% (SDS-PAGE)
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基因名:
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Uniprot No.:
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别名:BAP; BiP associated protein; BiP-associated protein; Endoplasmic reticulum chaperone SIL 1; Endoplasmic reticulum chaperone SIL1; MSS; Nucleotide exchange factor SIL 1; Nucleotide exchange factor SIL1; SIL 1; sil1; SIL1 homolog; SIL1 homolog endoplasmic reticulum chaperone (S. cerevisiae); SIL1 homolog endoplasmic reticulum chaperone; SIL1_HUMAN; UGL 5; ULG5
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种属:Homo sapiens (Human)
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蛋白长度:Full Length of Mature Protein
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表达区域:32-461
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氨基酸序列HQNLKEFAL TNPEKSSTKE TERKETKAEE ELDAEVLEVF HPTHEWQALQ PGQAVPAGSH VRLNLQTGER EAKLQYEDKF RNNLKGKRLD INTNTYTSQD LKSALAKFKE GAEMESSKED KARQAEVKRL FRPIEELKKD FDELNVVIET DMQIMVRLIN KFNSSSSSLE EKIAALFDLE YYVHQMDNAQ DLLSFGGLQV VINGLNSTEP LVKEYAAFVL GAAFSSNPKV QVEAIEGGAL QKLLVILATE QPLTAKKKVL FALCSLLRHF PYAQRQFLKL GGLQVLRTLV QEKGTEVLAV RVVTLLYDLV TEKMFAEEEA ELTQEMSPEK LQQYRQVHLL PGLWEQGWCE ITAHLLALPE HDAREKVLQT LGVLLTTCRD RYRQDPQLGR TLASLQAEYQ VLASLELQDG EDEGYFQELL GSVNSLLKEL R
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蛋白标签:Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially. -
产品提供形式:Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand. -
复溶:We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
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储存条件:Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
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保质期:The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C. -
货期:Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
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注意事项:Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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Datasheet :Please contact us to get it.
相关产品
靶点详情
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功能:Required for protein translocation and folding in the endoplasmic reticulum (ER). Functions as a nucleotide exchange factor for the ER lumenal chaperone HSPA5.
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基因功能参考文献:
- SIL1-depleted HEK293 cells are an appropriate model to identify proteins modulated by SIL1 expression level. PMID: 26468156
- In a child with Marinesco-Sjogren syndrome it was found that a mutation in SIL1 affected the 5' UTR, translation initiation site and the endoplasmic reticulum-targeting signal sequence. PMID: 27544240
- this case study is the first report on Chinese Marinesco-Sjogren syndrome (MSS) patients, MSS complicated by Dandy-Walker syndrome (DWS), and a nonstop mutation in SIL1; our findings imply the pathogenetic association between DWS and MSS PMID: 27106665
- Two NEFs, Grp170 and Sil1, trigger toxin release from BiP to enable successful retrotranslocation and clarify the fate of the toxin after it disengages from BiP. PMID: 25877869
- This study demonistrated that SIL1 mutation in patient with ataxia telangiectasia PMID: 24631270
- The mutations prevent SIL1 from interacting with and regulating HSPA5, leading to abnormal neuronal morphology and migration. PMID: 24473200
- The study confirms the previous findings of mutations in SIL1 being the major cause of Marinesco-Sjogren syndrome. PMID: 24176978
- The clinical features and two novel SIL1 mutations of four Dutch patients with Marinesco-Sjogren syndrome are described PMID: 23062754
- the very C-terminal residues of SIL1 play a role in its structural integrity rather than its localization. PMID: 22219183
- The patients described here manifested the cardinal features of Marinesco-Sjogren syndrome, but did not exhibit any mutation in the exons and flanking introns of the SIL1 gene. PMID: 22115007
- Some reported cases of Marinesco-Sjogren syndrome without base alterations in the SIL1 gene are caused by deletions rather than locus heterogeneity. PMID: 20111056
- Interactions between Kar2p and its nucleotide exchange factors Sil1p and Lhs1p are mechanistically distinct PMID: 20430899
- BAP serves as a nucleotide exchange factor for BiP PMID: 12356756
- Nine distinct mutations that would disrupt the SIL1 protein in individuals with Marinesco-Sjogren syndrome were identified. PMID: 16282977
- Four Marinesco-Sjogren syndrome-associated loss-of-function mutations in SIL1 leading to disturbed SIL1-HSPA5 interaction and protein folding were identified. PMID: 16282978
- A novel mutation in BAP/SIL1 gene causes Marinesco-Sjogren syndrome in an extended pedigree. PMID: 17026626
- SIL1 mutation is associated with Marinesco-Sjogren syndrome PMID: 18285827
- We sequenced the entire SIL1-coding region in 3 unrelated Japanese patients with classical MSS and identified a novel homozygous frameshift insertion mutation, 936_937insG, in exon 9 in all 3 patients. PMID: 18395226
- data report two novel SIL1 missense mutations in two consanguineous Pakistani families affected with Marinesco-Sjogren syndrome PMID: 19471582
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相关疾病:Marinesco-Sjoegren syndrome (MSS)
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亚细胞定位:Endoplasmic reticulum lumen.
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蛋白家族:SIL1 family
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组织特异性:Highly expressed in tissues which produce large amounts of secreted proteins such as kidney, liver and placenta. Also expressed in colon, heart, lung, ovary, pancreas, peripheral leukocyte, prostate, spleen and thymus. Expressed at low levels throughout t
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数据库链接:
HGNC: 24624
OMIM: 248800
KEGG: hsa:64374
STRING: 9606.ENSP00000265195
UniGene: Hs.483521
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