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  4. Recombinant Human Nucleus accumbens-associated protein 1 (NACC1)

Recombinant Human Nucleus accumbens-associated protein 1 (NACC1)

  • 中文名称：
    人NACC1重组蛋白
  • 货号：
    CSB-YP836291HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人NACC1重组蛋白
  • 货号：
    CSB-EP836291HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人NACC1重组蛋白
  • 货号：
    CSB-EP836291HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人NACC1重组蛋白
  • 货号：
    CSB-BP836291HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人NACC1重组蛋白
  • 货号：
    CSB-MP836291HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    NACC1
  • Uniprot No.：
  • 别名：
    BEND8; BTB Domain Containing 14B; BTB/POZ domain-containing protein 14B; btbd14b; FLJ37383; NAC-1; NAC1; Nacc1; NACC1_HUMAN; Nucleus accumbens-associated protein 1
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-527
  • 氨基酸序列
    MAQTLQMEIP NFGNSILECL NEQRLQGLYC DVSVVVKGHA FKAHRAVLAA SSSYFRDLFN NSRSAVVELP AAVQPQSFQQ ILSFCYTGRL SMNVGDQFLL MYTAGFLQIQ EIMEKGTEFF LKVSSPSCDS QGLHAEEAPS SEPQSPVAQT SGWPACSTPL PLVSRVKTEQ QESDSVQCMP VAKRLWDSGQ KEAGGGGNGS RKMAKFSTPD LAANRPHQPP PPQQAPVVAA AQPAVAAGAG QPAGGVAAAG GVVSGPSTSE RTSPGTSSAY TSDSPGSYHN EEDEEEDGGE EGMDEQYRQI CNMYTMYSMM NVGQTAEKVE ALPEQVAPES RNRIRVRQDL ASLPAELINQ IGNRCHPKLY DEGDPSEKLE LVTGTNVYIT RAQLMNCHVS AGTRHKVLLR RLLASFFDRN TLANSCGTGI RSSTNDPRRK PLDSRVLHAV KYYCQNFAPN FKESEMNAIA ADMCTNARRV VRKSWMPKVK VLKAEDDAYT TFISETGKIE PDMMGVEHGF ETASHEGEAG PSAEALQ
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

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靶点详情

  • 功能：
    Functions as a transcriptional repressor. Seems to function as a transcriptional corepressor in neuronal cells through recruitment of HDAC3 and HDAC4. Contributes to tumor progression, and tumor cell proliferation and survival. This may be mediated at least in part through repressing transcriptional activity of GADD45GIP1. Required for recruiting the proteasome from the nucleus to the cytoplasm and dendritic spines.
  • 基因功能参考文献：
    1. knockdown of HOXA9 abrogated NAC1induced drug resistance. PMID: 28713930
    2. NAC1 forms a protein complex to function as a transcriptional regulator in cancer cells PMID: 27424155
    3. a mutation in NACC1 causes microcephaly, profound developmental delays and/or intellectual disability, cataracts, severe epilepsy including infantile spasms, irritability, failure to thrive, and stereotypic hand movements PMID: 28132692
    4. miR-339-5p inhibits migration and invasion in ovarian cancer by targeting NACC1 and BCL6. miR-339-5p may be a biomarker of metastasis in ovarian cancer; NACC1 had a predictive value for ovarian cancer progression PMID: 26553360
    5. NAC1 has potential as a marker for distinguishing OED from CIS/OSCC PMID: 26172271
    6. NACC1 can be modified by SUMO paralogues, and cooperates with promyelocytic leukemia protein. PMID: 25891951
    7. strategy for the purification of tethered POZ domains that form forced heterodimers is described, and crystal structures of the heterodimeric POZ domains of Miz1/BCL6 and of Miz1/NAC1 are reported PMID: 25484205
    8. low expression of NAC1 predicts poor prognosis for patients with pancreatic ductal adenocarcinoma. PMID: 23252869
    9. The identification of an NAC1 NLS thus clarifies the mechanism through which NAC1 translocates to the nucleus to regulate the transcription of genes involved in oncogenicity and pluripotency. PMID: 22665369
    10. Uterine sarcomas with NAC1 overexpression are clinically the most aggressive, chemoresistant, and radioresistant tumors. PMID: 22993327
    11. Results not only reveal a previously unrecognized function of NAC1, the molecular pathway involved and its impact on pathogenesis of tumor initiation and development, but also identify a novel senescence regulator PMID: 22665267
    12. NAC1 expression was significantly correlated with FASN expression in both OCCC samples and OCCC cell lines. PMID: 22653145
    13. NAC1 overexpression is critical to the growth and survival of cervical carcinomas irrespective of histologic type. PMID: 21889186
    14. NAC1 is identified as a novel regulator of autophagy PMID: 21743489
    15. These data suggest that the acetylation status of CTTN modulated by the NACC1-HDAC6 deacetylation system induces acceleration of melanoma cell migration activity via an actin-dependent cellular process PMID: 21562571
    16. Our data suggest that amplification at the ch19p13.2 NACC1 locus, leading to NAC1 overexpression, is one of the molecular genetic alterations associated with early tumor recurrence in ovarian cancer. PMID: 21240255
    17. These results indicate that a cell cycle-dependent regulatory mechanism controls NAC1 body formation in the nucleus and suggest that NAC1 body dynamics are associated with mitosis or cytokinesis. PMID: 21301057
    18. NAC1 is a potential stem cell pluripotency factor expression in normal endometrium, endometrial hyperplasia and endometrial carcinoma PMID: 20372782
    19. NAC1 over-expression is critical to the growth and survival of ovarian cancers. Furthermore, they suggest that NAC1 silencing RNA-induced phenotypes depend on the expression status of the targeted cell line. PMID: 20869761
    20. NAC-1 is a tumor recurrence-associated gene with oncogenic potential; interactions between BTB/POZ domains of NAC-1 proteins are critical to form the discrete NAC-1 nuclear bodies and essential for tumor cell proliferation and survival. PMID: 17130457
    21. NAC-1 expression is higher in ovarian carcinoma cells in effusions compared with their solid tumor counterparts. PMID: 17391728
    22. NAC-1 may play an important role in cervical carcinomas. PMID: 18347169
    23. NAC-1 regulates Taxol resistance in ovarian cancer PMID: 18483383
    24. Therefore, we conclude that NAC1 functions as a corepressor for POZ/BTB proteins expressed in the mature CNS. PMID: 19121354
    25. NAC-1, a potential stem cell pluripotency factor, contributes to paclitaxel resistance in ovarian cancer by inactivating Gadd45v pathway. PMID: 19305429
    26. C-terminal alpha-helix of the Nac1 POZ domain is shorter than that observed in most other POZ-domain transcription factors PMID: 19407373

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  • 相关疾病：
    Neurodevelopmental disorder with epilepsy, cataracts, feeding difficulties, and delayed brain myelination (NECFM)
  • 亚细胞定位：
    Nucleus. Cytoplasm.
  • 组织特异性：
    Overexpressed in several types of carcinomas including ovarian serous carcinomas. Expression levels positively correlate with tumor recurrence in ovarian serous carcinomas, and intense immunoreactivity in primary ovarian tumors predicts early recurrence.
  • 数据库链接：

    HGNC: 20967

    OMIM: 610672

    KEGG: hsa:112939

    STRING: 9606.ENSP00000292431

    UniGene: Hs.531614