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  4. Recombinant Human Oligodendrocyte transcription factor 1 (OLIG1), partial

Recombinant Human Oligodendrocyte transcription factor 1 (OLIG1), partial

  • 中文名称：
    人OLIG1重组蛋白
  • 货号：
    CSB-EP016328HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人OLIG1重组蛋白
  • 货号：
    CSB-EP016328HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人OLIG1重组蛋白
  • 货号：
    CSB-BP016328HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人OLIG1重组蛋白
  • 货号：
    CSB-MP016328HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Name:OLIG1 Synonyms:BHLHB6, BHLHE21
  • Uniprot No.：
  • 别名：
    Basic domain helix loop helix protein class B 6; Basic domain helix loop helix protein class B6; BHLH B6; BHLHB 6; bHLHb6; bHLHe21; Class B basic helix-loop-helix protein 6; Class E basic helix-loop-helix protein 21; Olig 1; Olig1; OLIG1_HUMAN; Oligo 1; Oligo1; Oligodendrocyte lineage transcription factor 1; Oligodendrocyte specific bHLH transcription factor 1; Oligodendrocyte transcription factor 1
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 表达区域：
    1-271
  • 氨基酸序列
    MYYAVSQARV NAVPGTMLRP QRPGDLQLGA SLYELVGYRQ PPSSSSSSTS STSSTSSSST TAPLLPKAAR EKPEAPAEPP GPGPGSGAHP GGSARPDAKE EQQQQLRRKI NSRERKRMQD LNLAMDALRE VILPYSAAHC QGAPGRKLSK IATLLLARNY ILLLGSSLQE LRRALGEGAG PAAPRLLLAG LPLLAAAPGS VLLAPGAVGP PDALRPAKYL SLALDEPPCG QFALPGGGAG GPGLCTCAVC KFPHLVPASL GLAAVQAQFS K
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Promotes formation and maturation of oligodendrocytes, especially within the brain. Cooperates with OLIG2 to establish the pMN domain of the embryonic neural tube.
  • 基因功能参考文献：
    1. Olig1 has a critical function in regulation of postnatal neural progenitor cell production in response to Noggin. PMID: 28253550
    2. This study demonstrated that increased expression of mRNA of OLIG1 in ventral prefrontal white matter in major depressive disorder. PMID: 25930075
    3. Olig1 is a Smad cofactor involved in TGF-beta-induced cell motility PMID: 23720758
    4. This study review OLIG1 have developmental functions in patterning, neuron subtype specification and the formation of oligodendrocytes and play the role in the postnatal brain during repair processes and in neurological disease states. PMID: 23165259
    5. Olig1 was not expressed in freshly isolated oligodendrocytes, but is expressed from the beginning of process extension until membrane maintenance. PMID: 21446039
    6. analysis of conserved and non-conserved functional elements at the Olig1 and Olig2 locus PMID: 21206754
    7. Olig1 and Olig2 transcription factors in the human central nervous system are important not only for differentiation of the oligodendrocyte lineage, but they may also have a role in neural cell specification. PMID: 16267213
    8. identified novel coding variants in the Olig1 gene, including a trinucleotide repeat, but found no evidence to support the hypothesis that genetic variation in Olig1 influences susceptibility to multiple sclerosis PMID: 16820418
    9. Mutations in OLIG1 and OLIG2 are not likely to be associated with this subgroup of hypomyelinating disorders. PMID: 17171653
    10. OLIG1 protein expression significantly correlates with overall survival in non-small cell lung cancer patients PMID: 17388669
    11. No significan correlation was found between proliferation index in pilocytic astrocytomas and Olig-1 expression. PMID: 17690840

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  • 亚细胞定位：
    Nucleus.
  • 组织特异性：
    Expressed in the brain, in oligodendrocytes. Strongly expressed in oligodendrogliomas, while expression is weak to moderate in astrocytomas. Expression in glioblastomas is highly variable.
  • 数据库链接：

    HGNC: 16983

    OMIM: 606385

    KEGG: hsa:116448

    STRING: 9606.ENSP00000371785

    UniGene: Hs.56663