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  4. Recombinant Human Orexigenic neuropeptide QRFP (QRFP)

Recombinant Human Orexigenic neuropeptide QRFP (QRFP)

  • 货号：
    CSB-YP019138HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP019138HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP019138HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP019138HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP019138HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    QRFP
  • Uniprot No.：
  • 别名：
    26RFa; Neuropeptide RF-amide; OX26_HUMAN; P518; Pyroglutamylated arginine-phenylalanine-amide peptide; QRF-amide; Qrfp
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Cytoplasmic domain
  • 表达区域：
    91-133
  • 氨基酸序列
    QDEGSEATGF LPAAGEKTSG PLGNLAEELN GYSRKKGGFS FRF
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Stimulates feeding behavior, metabolic rate and locomotor activity and increases blood pressure. May have orexigenic activity. May promote aldosterone secretion by the adrenal gland.
  • 基因功能参考文献：
    1. we show a moderate positive correlation between plasma 26RFa levels and insulin in patients with diabetes. Plasma 26RFa increases in response to glucose tolerance test. 26RFa and its receptor GPR103 are present in human pancreatic beta-cells and gut. PMID: 25858563
    2. Data indicate that 26RFa may participate to the development of prostate cancer at the androgen independent state by promoting the neuroendocrine differentiation and the migration of cancer cells via autocrine/paracrine mechanisms. PMID: 22863147
    3. High levels of circulating 26RFa observed in anorexia nervosa patients might reflect an adaptive mechanism of the organism to promote energy intake and to increase fat stores in response to undernutrition. PMID: 22466335
    4. Results suggest that GPR103b and QRFP work in an autocrine/paracrine manner to regulate adipogenesis. PMID: 20534693
    5. P518 exhibited high affinity for SP9155. The peptide P518 precursor gene is predominantly expressed in various brain regions, coronary arteries, thyroid and parathyroid glands, large intestine, colon, bladder, testes, and prostate. PMID: 12714592
    6. Solution conformation of 26RFa by using two-dimensional NMR spectroscopy in different media was investigated. PMID: 15808908
    7. A bioinformatic search for peptides related to frog 26RFa reveals the presence of homologous sequences in the human genome. PMID: 15891009
    8. Characterization of 26RFa-related peptides showed that two distinct molecular forms of 26RFa are present in the human hypothalamus and spinal cord, i.e. 26RFa and an N-terminally elongated form of 43 amino acids designated 43RFa. PMID: 16899066

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    RFamide neuropeptide family
  • 组织特异性：
    Expressed widely in the brain with highest expression levels in the cerebellum, medulla, pituitary, retina, vestibular nucleus, and white matter. Also expressed in the bladder, colon, coronary artery, parathyroid gland, prostate, testis, and thyroid.
  • 数据库链接：

    HGNC: 29982

    OMIM: 609795

    KEGG: hsa:347148

    STRING: 9606.ENSP00000345487

    UniGene: Hs.660704