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  4. Recombinant Human Ornithine decarboxylase (ODC1)

Recombinant Human Ornithine decarboxylase (ODC1)

In Stock
  • 货号：
    CSB-EP016269HU
  • 规格：
    ￥2328
  • 图片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
    • Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP016269HU could indicate that this peptide derived from E.coli-expressed Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) ODC1 .
    • Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP016269HU could indicate that this peptide derived from E.coli-expressed Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) ODC1 .
  • 其他：

产品详情

  • 纯度：
    Greater than 90% as determined by SDS-PAGE.
  • 基因名：
    ODC1
  • Uniprot No.：
  • 别名：
    DCOR_HUMAN; Dodc1; Odc 1; ODC; Odc1; ODC2; Ornithine decarboxylase 1; Ornithine decarboxylase 2; Ornithine decarboxylase; Ornithine decarboxylase structural 1; RNODC
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length
  • 来源：
    E.coli
  • 分子量：
    71.1 kDa
  • 表达区域：
    1-461aa
  • 氨基酸序列
    MNNFGNEEFDCHFLDEGFTAKDILDQKINEVSSSDDKDAFYVADLGDILKKHLRWLKALPRVTPFYAVKCNDSKAIVKTLAATGTGFDCASKTEIQLVQSLGVPPERIIYANPCKQVSQIKYAANNGVQMMTFDSEVELMKVARAHPKAKLVLRIATDDSKAVCRLSVKFGATLRTSRLLLERAKELNIDVVGVSFHVGSGCTDPETFVQAISDARCVFDMGAEVGFSMYLLDIGGGFPGSEDVKLKFEEITGVINPALDKYFPSDSGVRIIAEPGRYYVASAFTLAVNIIAKKIVLKEQTGSDDEDESSEQTFMYYVNDGVYGSFNCILYDHAHVKPLLQKRPKPDEKYYSSSIWGPTCDGLDRIVERCDLPEMHVGDWMLFENMGAYTVAAASTFNGFQRPTIYYVMSGPAWQLMQQFQNPDFPPEVEEQDASTLPVSCAWESGMKRHRAACASASINV
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-SUMO-tagged and C-terminal Myc-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Tris-based buffer,50% glycerol
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    3-7 business days
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis.
  • 基因功能参考文献：
    1. Extracellular polyamines induced proliferation and cancer cell migration by inducing ODC and SSAT expression, and the Akt1-mediated pathway. PMID: 28157137
    2. Ornithine decarboxylase (ODC) plays a key role in prostate tumorigenesis and that the polyamine pathway is altered as early as high-grade prostate intraepithelial neoplasia (HGPIN). PMID: 27770613
    3. Findings suggest that targeting ornithine decarboxylase 1 (ODC1) could be an attractive option for molecular therapy of hepatocellular carcinoma (HCC). PMID: 27592554
    4. Binding of RS1-Reg to ODC1 inhibits the enzymatic activity at low intracellular glucose, which is blunted at high intracellular glucose. PMID: 27555600
    5. mechanistic study of the molecular interactions between antizyme inhibitor and its interacting proteins CCND1 and ornithine decarboxylase PMID: 26172301
    6. We earlier presented evidence for a physical interaction between ODC and SPR and we showed that RNAi-mediated knockdown of SPR expression significantly reduced native ODC enzyme activity and impeded Neuroblastoma cell proliferation. PMID: 26093909
    7. Bag-1 indirectly affects cell survival through c-Myc activated signalling that causes elevation of ornithine decarboxylase levels, leading to an increase of the polyamine content. PMID: 26178413
    8. High ODC expression is associated with Medulloblastoma. PMID: 26460945
    9. Data suggest that down-regulation of ODC (using siRNA or pharmacologic inhibitor) in bone marrow-derived mesenchymal stem cells results in reduced intracellular polyamines (putrescine, spermidine, and spermine) and enhanced osteogenesis. PMID: 26140984
    10. tumor ornithine decarboxylase level heterogeneity increased with increasing tumor malignancy PMID: 17582600
    11. The results suggested that the ODC gene might act as a prognostic factor for breast cancer and it could be a promising therapeutic target. PMID: 18330478
    12. BTF3, HINT1, NDRG1 and ODC1 protein over-expression in human prostate cancer tissue PMID: 24386364
    13. Akt activation by ODC+COX-2 over-expression. PMID: 24260338
    14. s identified SPR as a novel regulator of ODC enzyme activity and, based on clinical evidence, present a model in which SPR drives ODC-mediated malignant progression in neuroblastoma. PMID: 24096079
    15. ODC overexpression suppresses the expression of tumstatin, which may provide fundamental evidence for the combination of anti-angiogenic therapy and conventional therapy for cancer treatment. PMID: 24002681
    16. The results of this study suggest that specific genetic variants in a subset of glutamatergic (GRIN2B) and polyaminergic (ODC1) neurosystem genes may be of importance in certain suicidal subjects. PMID: 22850629
    17. There are five conserved residues in ODC. PMID: 23872168
    18. Based on the investigation of the polyamine metabolite pathway, these data establish that the downstream metabolites of ornithine are increased, potentially implicating ornithine decarboxylase activity in AD pathology. PMID: 23917584
    19. Overexpression of antizyme (AZ), an ornithine decarboxylase (ODC) inhibitory protein, suppressed ERalpha expression, suggesting that ODC plays an important role in regulation of ERalpha expression. PMID: 22976807
    20. Introduction of a fluorine atom at C3 of 3-deazauridine shifts its antimetabolic activity from inhibition of CTP synthetase to inhibition of orotidylate decarboxylase, an early event in the de novo pyrimidine nucleotide biosynthesis pathway. PMID: 22730407
    21. Variants of the ornithine decarboxylase gene influence risk of colorectal adenoma and aspirin chemoprevention. PMID: 21930798
    22. the mechanism of formation of the internal aldimine, a common intermediate to most pyridoxal 5'-phosphate (PLP)-dependent enzymes PMID: 21854048
    23. There was no significant association between ODC G316A and risk of colorectal cancer for either heterozygotes or rare allele homozygotes. PMID: 20456464
    24. Studies provide lead compounds for inhibitors of ornithine decarboxylase and human histidine decarboxylase. PMID: 21454364
    25. Gingival ornithine decarboxylase levels were higher in the gingivitis group compared to the periodontitis and healthy groups at baseline. PMID: 20831369
    26. Overexpression of ODC suppresses thapsigargin-induced apoptosis, blocks caspase-4 activation and PERK phosphorylation,and attenuates CHOP expression. It inhibits Bak increase and maintains Bcl-2 expression, blocking the intrinsic pathway of apoptosis. PMID: 20814750
    27. Ornithine decarboxylase induces hypomethylation of genome DNA and histone H3 lysine 9 dimethylation in human oral cancer cell line. PMID: 20838441
    28. ODC activity, which AZIN2 is assumed to regulate, is strongly associated with cell growth and transformation. PMID: 19832840
    29. Low Ornithine decarboxylase mRNA expression is associated with more aggressive non-small-cell lung cancer. PMID: 20199977
    30. Overexpression of ornithine decarboxylase enhances endothelial proliferation by suppressing endostatin expression. PMID: 11830503
    31. ODC activity reflects aggressive growth and malignization in meningiomas. PMID: 15015770
    32. Data show that expressing whole proteins, protein domains, or peptide ligands fused to the N terminus of ornithine decarboxylase promotes proteasome-dependent degradation of these chimeric fusion proteins and their interacting cellular target proteins. PMID: 16219697
    33. review of key factors that contribute to the regulation of ornithine decarboxylase levels, which can occur at the levels of transcription, translation, and protein turnover [review] PMID: 16459331
    34. findings show that antibody-bound amyloid precursor protein induces expression of ornithine decarboxylase PMID: 16469300
    35. Data suggest that prolaction-mediated induction of ornithine decarboxylase activity enhances expression of Bcl-2 strongly enough to bring about prolactin's anti-apoptotic function. PMID: 16520895
    36. This is the first report showing the existence of a causal relationship between ornithine decarboxylase expression, Erk and p38 MAP kinase activation, and MMP-2 expression. PMID: 17088079
    37. no association observed between the ODC ploymorphism and H. pylori seropositivity; results did not support the hypothesis that the different genetic traits in the ODC-polyamine pathway are associated with susceptibility to persistent H. pylori infection PMID: 17378176
    38. The expression of ornithine decarboxylase is positively correlated with the degree of malignity of gastric mucosa and development of gastric lesions. PMID: 17569126
    39. Among colorectal cancer patients, ODC activity in cancer tissue was correlated with T factors, lymph node metastasis and stages. PMID: 17957960
    40. Antisense RNA specifically inhibited the expression of ODC and AdoMetDC and the synthesis of polyamine, while it induced p21 expression, resulting in cell growth arrest in the G1 phase in prostate cancer cells. PMID: 18548481
    41. Elevated ODC1 (independent of MYCN amplification) was associated with reduced survival in a large independent neuroblastoma cohort. PMID: 19047152
    42. sporadic breast cancer, the presence of at least one A allele in ornithine decarboxylase is protective against the disease. PMID: 19225907
    43. The ODC1 SNP may be protective for colon adenoma recurrence and detrimental for survival after colon cancer diagnosis. PMID: 19789310

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  • 蛋白家族：
    Orn/Lys/Arg decarboxylase class-II family
  • 数据库链接：

    HGNC: 8109

    OMIM: 165640

    KEGG: hsa:4953

    STRING: 9606.ENSP00000234111

    UniGene: Hs.467701