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  4. Recombinant Human Oxidoreductase HTATIP2 (HTATIP2)

Recombinant Human Oxidoreductase HTATIP2 (HTATIP2)

  • 中文名称：
    人HTATIP2重组蛋白
  • 货号：
    CSB-YP863125HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人HTATIP2重组蛋白
  • 货号：
    CSB-EP863125HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人HTATIP2重组蛋白
  • 货号：
    CSB-EP863125HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人HTATIP2重组蛋白
  • 货号：
    CSB-BP863125HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人HTATIP2重组蛋白
  • 货号：
    CSB-MP863125HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    HTATIP2
  • Uniprot No.：
  • 别名：
    30 kDa HIV 1 TAT interacting protein; 30 kDa HIV-1 TAT-interacting protein; 30 kDa HIV1 TAT interacting protein; CC3; FLJ26963; HIV 1 Tat interacting protein 2 30kDa; HIV 1 Tat interacting protein 2; HIV-1 TAT-interactive protein 2; HTAI2_HUMAN; HTATIP 2; HTATIP2; Oxidoreductase HTATIP2; SDR44U1; Short chain dehydrogenase/reductase family 44U member 1; Tat interacting protein (30kDa)
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-242
  • 氨基酸序列
    AETEALSKL REDFRMQNKS VFILGASGET GRVLLKEILE QGLFSKVTLI GRRKLTFDEE AYKNVNQEVV DFEKLDDYAS AFQGHDVGFC CLGTTRGKAG AEGFVRVDRD YVLKSAELAK AGGCKHFNLL SSKGADKSSN FLYLQVKGEV EAKVEELKFD RYSVFRPGVL LCDRQESRPG EWLVRKFFGS LPDSWASGHS VPVVTVVRAM LNNVVRPRDK QMELLENKAI HDLGKAHGSL KP
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Oxidoreductase required for tumor suppression. NAPDH-bound form inhibits nuclear import by competing with nuclear import substrates for binding to a subset of nuclear transport receptors. May act as a redox sensor linked to transcription through regulation of nuclear import. Isoform 1 is a metastasis suppressor with proapoptotic as well as antiangiogenic properties. Isoform 2 has an antiapoptotic effect.
  • 基因功能参考文献：
    1. These results suggest that TIP30, as a tumor suppressor in the bladder cancer, might be served as a target in cancer therapies in the future. PMID: 30249892
    2. Binding of HIV1 Tat to TIP30 enhanced epithelial-to-mesenchymal transition and metastasis by regulating the nuclear translocation of Snail. PMID: 30099830
    3. Cholangiocarcinoma patients who had high methylation of HTATIP2 and low methylation of UCHL1 showed longer overall survival than those with low HTATIP2 methylation and high UCHL1 methylation. PMID: 29359783
    4. the results suggest that downregulation of TIP30 may result from HBV infection, and subsequently promotes the progression of HCC. PMID: 27418384
    5. TIP30 expression is associated with a good prognosis in patients with tumors. PMID: 28036326
    6. these data suggest that positive MCM2 and negative TIP30 expression are closely correlated with the clinical, pathological and biological parameters, in addition to poor prognosis in patients with gallbladder cancer. PMID: 27748889
    7. The results of the present study indicated that TIP30 may suppress oncogenesis and glioma progression, thereby improving the prognosis of patients with glioma. PMID: 26718891
    8. combination of sorafenib and metformin inhibits proliferation and invasion in vitro, prolongs median survival, and reduces lung metastasis of HCC in vivo. This effect is closely associated with the upregulation of TIP30 PMID: 26752068
    9. Increased HMGB1 and cleaved caspase-3 stimulate the proliferation of tumor cells and are correlated with the poor prognosis in colorectal cancer PMID: 25986235
    10. Data iindicate TIP30 was a marker in predicting the prognosis of esophageal squamous cell carcinoma (ESCC). PMID: 25544767
    11. the present study showed that loss of HTATIP2 expression was a frequent event in glioma and is associated with poor prognosis. PMID: 25617528
    12. The results suggest a novel and critical role of TIP30 involved in hepatocellular carcinoma progression and aggressiveness. PMID: 24681951
    13. Meta-analysis suggests that the rs2230199 C/G, rs1047286 C/T, rs11569536 G/A and rs2250656 A/G SNPs in the CC3 gene may be associated with age-related macular degeneration risk. PMID: 25688879
    14. The combination of HTATIP2 and MVD predicts the converse survival of HCC with or without sorafenib intervention. PMID: 25008315
    15. miR-10b promotes pancreatic cancer cell proliferation and invasion by suppressing TIP30. PMID: 24096486
    16. TIP30-induced downregulation of cyclin D1 transcription antagonizes EGFR signaling and suppresses tumorigenesis PMID: 25135222
    17. Decreased TIP30 expression is associated with pancreatic cancer. PMID: 24037692
    18. We demonstrated the potential role of HTATIP2/TIP30 in ovarian cancer for the first time, thereby enlightening future studies targeting HTATIP2/TIP30 in ovarian cancer treatment, diagnosis, and prevention. PMID: 23800048
    19. TIP30 binds to the DNA-binding domain and the C-terminal domain of p53 PMID: 23178973
    20. The loss of CC3/TIP30 is related to occurrence and development in breast cancer, suggesting early onset of metastasis and recurrence. PMID: 22490293
    21. TIP30 acts as a crucial regulator in suppressing cytoplasmic and nuclear EGFR signaling in the lung.TIP30 functions as a tumor suppressor to inhibit EGFR cytoplasmic and nuclear signaling and suppress adenocarcinogenesis in the lung. PMID: 22733137
    22. overexpression of MCM2 or loss of expression of Tat-interacting protein 30 is closely related to carcinogenesis, progression, biological behavior, and prognosis of gallbladder adenocarcinoma. PMID: 21543106
    23. The TIP30 complex facilitates biological membrane fusion through modification of phosphatidic acid on membranes. PMID: 21731680
    24. TIP30 complex regulates EGFR endocytosis by facilitating the transport of V-ATPases from trans-Golgi network to early endosomes. PMID: 21252234
    25. Data suggest that metabolic flexibility acquired by cells after silencing of CC3 could be directly relevant to the development of metastatic and aggressive human tumors that frequently have low or absent expression of CC3. PMID: 21150275
    26. These results demonstrate that promoter methylation is involved in the decreased expression of TIP30 tumor suppressor gene in human colorectal carcinoma. PMID: 19798571
    27. Excess of cellular CC3 has a significant negative effect on DNA repair after UV and oxidant exposure, while silencing of endogenous CC3 slightly delays repair of UV-induced damage. PMID: 20374651
    28. we examine the pathophysiological nature of remyelination failure in chronic multiple sclerosis and discuss the role of TIP30 as a novel therapeutic target--review PMID: 19839715
    29. TIP30 interacts with an estrogen receptor alpha-interacting coactivator CIA and regulates ERalpha-mediated c-myc transcription. PMID: 15073177
    30. These data indicate that shear-induced VWF binding to platelet GpIb-IX-V activates Pyk2, ERK1/2, p38, and cPLA2. PMID: 15493507
    31. TIP30 predisposes hepatoblastoma cells to apoptosis through regulating expression levels of these genes. PMID: 15633220
    32. Finally, two inhibitors of cyclin-dependent kinase 9 (a dominant negative CDK9 and flavopiridol) repressed activity from the MR and BMPR2 promoters PMID: 16615932
    33. Overexpression of TIP30 might be a promising candidate as a treatment for HCC that would increase sensitivity to chemotherapeutic drugs. PMID: 16799960
    34. Data supported the theory that the expression of TIP30/CC3 had a suppressive function on tumor metastasis, and the decrease in expression of TIP30/CC3 is related to metastasis and may represent a new prognosticator in breast carcinoma. PMID: 17097132
    35. Translocation of Bax was essential for TIP30-induced apoptosis, whereas overexpression of the anti-apoptotic protein Bcl-xL delayed both second mitochondria-derived activator of caspases (Smac/DIABLO) release and onset of apoptosis. PMID: 17997990
    36. results suggest that TIP30 is involved in cellular oxidative stress surveillance and induces apoptosis through stabilization of p53 mRNA in hepatocellular carcinoma cells PMID: 18519672
    37. TIP30 plays a role in prostate cancer progression and that TIP30 overexpression may promote prostate cancer cell growth and metastasis. PMID: 18528861
    38. Novel pathway by which OPN and possibly other Ets-1 target genes involved in tumor metastasis are regulated by TIP30. Mechanism for metastasis promoted by TIP30 deficiency. PMID: 18537194
    39. a novel function of TIP30, which can possibly be used as an independent prognostic factor and a potential therapeutic target for gastric cancer. PMID: 18972434
    40. epigenetic silencing of Tip30 gene expression by CpG island DNA hypermethylation is associated with poor prognosis in patients with HCC PMID: 19010857
    41. Data suggest that oligodendrocyte precursor cells are pathogenic in multiple sclerosis and their nucleocytoplasmic transport is impaired due to abnormally upregulated TIP30. PMID: 19104151
    42. Decreased TIP30 expression promotes tumor metastasis in lung cancer. PMID: 19349353

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  • 亚细胞定位：
    Cytoplasm. Nucleus envelope.
  • 组织特异性：
    Ubiquitous. Highest level in liver. High levels in lung, skeletal muscle, pancreas and placenta. Moderate levels in heart and kidney. Low levels in brain. Not expressed or low levels in variant small cell lung carcinomas, 33% of hepatocellular carcinomas
  • 数据库链接：

    HGNC: 16637

    OMIM: 605628

    KEGG: hsa:10553

    STRING: 9606.ENSP00000392985

    UniGene: Hs.90753