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  4. Recombinant Human PCNA-interacting partner (PARPBP)

Recombinant Human PCNA-interacting partner (PARPBP)

  • 中文名称：
    人PARPBP重组蛋白
  • 货号：
    CSB-YP868339HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人PARPBP重组蛋白
  • 货号：
    CSB-EP868339HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人PARPBP重组蛋白
  • 货号：
    CSB-EP868339HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人PARPBP重组蛋白
  • 货号：
    CSB-BP868339HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人PARPBP重组蛋白
  • 货号：
    CSB-MP868339HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    PARPBP
  • Uniprot No.：
  • 别名：
    AROM; C12orf48; Chromosome 12 open reading frame 48; FLJ20641; PARP 1 binding protein; PARP-1 binding protein; PARP1 binding protein; PARP1-binding protein; PARPBP; PR1BP_HUMAN
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-579
  • 氨基酸序列
    MAVFNQKSVS DMIKEFRKNW RALCNSERTT LCGADSMLLA LQLSMAENNK QHSGEFTVSL SDVLLTWKYL LHEKLNLPVE NMDVTDHYED VRKIYDDFLK NSNMLDLIDV YQKCRALTSN CENYNTVSPS QLLDFLSGKQ YAVGDETDLS IPTSPTSKYN RDNEKVQLLA RKIIFSYLNL LVNSKNDLAV AYILNIPDRG LGREAFTDLK HAAREKQMSI FLVATSFIRT IELGGKGYAP PPSDPLRTHV KGLSNFINFI DKLDEILGEI PNPSIAGGQI LSVIKMQLIK GQNSRDPFCK AIEEVAQDLD LRIKNIINSQ EGVVALSTTD ISPARPKSHA INHGTAYCGR DTVKALLVLL DEEAANAPTK NKAELLYDEE NTIHHHGTSI LTLFRSPTQV NNSIKPLRER ICVSMQEKKI KMKQTLIRSQ FACTYKDDYM ISKDNWNNVN LASKPLCVLY MENDLSEGVN PSVGRSTIGT SFGNVHLDRS KNEKVSRKST SQTGNKSSKR KQVDLDGENI LCDNRNEPPQ HKNAKIPKKS NDSQNRLYGK LAKVAKSNKC TAKDKLISGQ AKLTQFFRL
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Required to suppress inappropriate homologous recombination, thereby playing a central role DNA repair and in the maintenance of genomic stability. Antagonizes homologous recombination by interfering with the formation of the RAD51-DNA homologous recombination structure. Binds single-strand DNA and poly(A) homopolymers. Positively regulate the poly(ADP-ribosyl)ation activity of PARP1; however such function may be indirect.
  • 基因功能参考文献：
    1. PARI is a latent modulator of stalled fork processing, which is required for stable genome inheritance under both endogenous and exogenous replication stress PMID: 28894029
    2. PARI inhibits homologous recombination in vivo, and its knockdown suppresses the UV sensitivity of RAD18-depleted cells PMID: 26792895
    3. PARI overexpression promotes genomic instability and pancreatic tumorigenesis. PMID: 23436799
    4. Knockdown of C12orf48 by siRNA in HeLa cells significantly suppressed their growth PMID: 23039964
    5. PARI suppresses inappropriate recombination events at mammalian replication forks. PMID: 22153967
    6. Demonstrated that C12orf48 protein could directly interact with Poly(ADP-ribose) Polymerase-1 (PARP-1). Knockdown of C12orf48 by siRNA in PDAC cells significantly suppressed their growth. PMID: 20931645

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  • 亚细胞定位：
    Cytoplasm. Nucleus. Note=Localizes to chromatin in response to S phase arrest but not in mitosis. Targeted to chromatin via its interaction with PCNA.
  • 蛋白家族：
    PARI family
  • 组织特异性：
    Restricted to testis. Overexpressed in multiple cancer cells.
  • 数据库链接：

    HGNC: 26074

    OMIM: 613687

    KEGG: hsa:55010

    STRING: 9606.ENSP00000351153

    UniGene: Hs.330663