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  4. Recombinant Human PDZ and LIM domain protein 7 (PDLIM7)

Recombinant Human PDZ and LIM domain protein 7 (PDLIM7)

  • 中文名称：
    人PDLIM7重组蛋白
  • 货号：
    CSB-YP865112HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人PDLIM7重组蛋白
  • 货号：
    CSB-EP865112HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人PDLIM7重组蛋白
  • 货号：
    CSB-EP865112HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人PDLIM7重组蛋白
  • 货号：
    CSB-BP865112HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人PDLIM7重组蛋白
  • 货号：
    CSB-MP865112HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    PDLIM7
  • Uniprot No.：
  • 别名：
    1110003B01Rik; Enigma; LIM domain protein; LIM domain protein enigma; LIM mineralization protein 1; Lim mineralization protein 3; LIM mineralization protein; LMP 1; LMP; LMP1; LMP3; PDLI7_HUMAN; PDLIM 7; Pdlim7; PDZ and LIM doamin protein 7; PDZ and LIM domain 7; PDZ and LIM domain protein 7; Protein enigma
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-457
  • 氨基酸序列
    MDSFKVVLEG PAPWGFRLQG GKDFNVPLSI SRLTPGGKAA QAGVAVGDWV LSIDGENAGS LTHIEAQNKI RACGERLSLG LSRAQPVQSK PQKASAPAAD PPRYTFAPSV SLNKTARPFG APPPADSAPQ QNGQPLRPLV PDASKQRLME NTEDWRPRPG TGQSRSFRIL AHLTGTEFMQ DPDEEHLKKS SQVPRTEAPA PASSTPQEPW PGPTAPSPTS RPPWAVDPAF AERYAPDKTS TVLTRHSQPA TPTPLQSRTS IVQAAAGGVP GGGSNNGKTP VCHQCHKVIR GRYLVALGHA YHPEEFVCSQ CGKVLEEGGF FEEKGAIFCP PCYDVRYAPS CAKCKKKITG EIMHALKMTW HVHCFTCAAC KTPIRNRAFY MEEGVPYCER DYEKMFGTKC HGCDFKIDAG DRFLEALGFS WHDTCFVCAI CQINLEGKTF YSKKDRPLCK SHAFSHV
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May function as a scaffold on which the coordinated assembly of proteins can occur. May play a role as an adapter that, via its PDZ domain, localizes LIM-binding proteins to actin filaments of both skeletal muscle and nonmuscle tissues. Involved in both of the two fundamental mechanisms of bone formation, direct bone formation (e.g. embryonic flat bones mandible and cranium), and endochondral bone formation (e.g. embryonic long bone development). Plays a role during fracture repair. Involved in BMP6 signaling pathway.
  • 基因功能参考文献：
    1. In enigma siRNA-transfected cells, cell viability, and the protein levels of AKT and survivin decreased. PMID: 29848705
    2. LMOD1, SYNPO2, PDLIM7, PLN, and SYNM down-regulation reflect the altered phenotype of smooth muscle cells in vascular disease and could be early sensitive markers of SMC dedifferentiation. PMID: 27470516
    3. Molecular basis of the overactive osteogenic process may at least in part involve a deregulation of the LMP-related pathway in calvarial cells. PMID: 22982077
    4. The results showed that LMP-1 inhibited cell apoptosis and induced survivin expression in nasal natural killer/T-cell lymphoma PMID: 25760809
    5. The results suggest local transduction with LMP-1 gene promotes osteogenesis and mineralization in distraction osteogenesis. PMID: 25641592
    6. LMP-1 mRNA level was regulated in a dose-dependent manner after transfection PMID: 25336289
    7. These results are consistent with a model in which binding of OspE to PDLIM7 during infection regulates the activity of PKC isoforms that bind to the PDLIM7 LIM domain. PMID: 25124035
    8. LMP1 expression suppressed the expression of Runx2 and BMP-2 in OS cells. PMID: 24762763
    9. High Enigma expression is associated with breast neoplasms. PMID: 24466333
    10. A direct interaction of Jab1 with LMP-1, is reported. PMID: 24078030
    11. Gene transfer of LMP3 upregulated Alkaline Phosphatase, Bone Sialoprotein and BMP2 gene expression and increased in vitro matrix mineralization in human PDL cell line. PMID: 22241179
    12. LMP3 induced the successful osteogenic differentiation of AFSC by inducing the expression of osteogenic markers and osteospecific transcription factors. PMID: 23097599
    13. findings indicate the existence of a new cell cycle-associated signaling pathway in which LMP1 regulates ERK-mediated Op18/stathmin signaling PMID: 22417000
    14. results suggested that LMP3 could affect the fine balance between cell proliferation/differentiation of mesenchymal cells mostly by modulating the TGF-beta1 signaling pathway PMID: 21061915
    15. SRF and Enigma coexpressed with MDM2 but not p53 in several liver and stomach tumors. PMID: 21060154
    16. LMP1 is a downstream gene of TGF-beta1, involved in periodontal ligament cell proliferation. PMID: 20348040
    17. isolated the complementary DNA (cDNA) for the human homologue of LMP-1 from an adult human heart cDNA library and showed that when overexpressed it is osteoinductive PMID: 11874232
    18. LIM-1 potentiates bone morphogenetic protein responsiveness via a novel interaction with Smurf1 resulting in decreased ubiquitination of Smads PMID: 16611643
    19. Enigma is involved in insulin-induced Glut 4 translocation by regulating cortical actin remodeling. PMID: 16803868
    20. s hypothesize that the HIV-1 TAT interacting protein can fuse with PDLIM7 and that the fusion proteins could be easily transduced through biological membranes and have biological activity. PMID: 17126496
    21. When transferred into mouse muscle fibers, a truncated form of LMP-1 induces pluripotent myoblastic C2C12 cells to differentiate into osteoblastic lineage. PMID: 17805464
    22. LMP-1 was expressed primarily in predentin, odontoblasts and blood vessel endothelial cells of healthy teeth. LMP-1 expression was found in unmineralized reparative dentin, odontoblast-like cells and pulp fibroblasts in teeth with caries and pulpitis. PMID: 18215669
    23. These studies provide evidence that overexpression of IGFBP-6 suppresses human and murine osteoblast differentiation, that IGFBP-6 and LMP-1 physically interact, and supports the conclusion that this interaction may be functionally relevant. PMID: 18395833
    24. LMP1 mediates serine 256 phosphorylation and nuclear entry of Annexin A2 via PLC-PKCalpha/PKCbeta pathway. PMID: 18412141
    25. Immunofluorescence stained cell numbers are increased after 20 MOI AdLMP1-GFP infection concordant with upregulation of mRNA expression. PMID: 18618069
    26. absence of any hexosamines (N-acetyl glucosamine or N-acetyl galactosamine) in chemical composition analysis of LMP-1 protein revealed that there is little or no post-translational glycosylation of the LMP-1 polypeptide in lung carcinoma cells PMID: 18989571
    27. PAR-2 is a possible mediator cooperating with LMP-1 and MMP9 to influence the progression of nasopharyngeal carcinoma by inducing angiogenesis and promoting lymph node metastasis. PMID: 19269113

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  • 亚细胞定位：
    Cytoplasm. Cytoplasm, cytoskeleton.
  • 组织特异性：
    Isoform 1 and isoform 2 are expressed ubiquitously, however, isoform 2 predominates in skeletal muscle, isoform 1 is more abundant in lung, spleen, leukocytes and fetal liver.
  • 数据库链接：

    HGNC: 22958

    OMIM: 605903

    KEGG: hsa:9260

    STRING: 9606.ENSP00000348099

    UniGene: Hs.533040