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  4. Recombinant Human Pancreatic secretory granule membrane major glycoprotein GP2 (GP2)

Recombinant Human Pancreatic secretory granule membrane major glycoprotein GP2 (GP2)

  • 中文名称：
    人GP2重组蛋白
  • 货号：
    CSB-YP009687HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人GP2重组蛋白
  • 货号：
    CSB-EP009687HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人GP2重组蛋白
  • 货号：
    CSB-EP009687HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人GP2重组蛋白
  • 货号：
    CSB-BP009687HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人GP2重组蛋白
  • 货号：
    CSB-MP009687HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    GP2
  • Uniprot No.：
  • 别名：
    DKFZp779K0533; Glycoprotein 2 (zymogen granule membrane); GP2; GP2_HUMAN; Pancreatic secretory granule membrane major glycoprotein GP2; Pancreatic zymogen granule membrane associated protein GP2; Pancreatic zymogen granule membrane protein GP-2; ZAP75
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    29-512
  • 氨基酸序列
    VQ RGYGNPIEAS SYGLDLDCGA PGTPEAHVCF DPCQNYTLLD EPFRSTENSA GSQGCDKNMS GWYRFVGEGG VRMSETCVQV HRCQTDAPMW LNGTHPALGD GITNHTACAH WSGNCCFWKT EVLVKACPGG YHVYRLEGTP WCNLRYCTVP RDPSTVEDKC EKACRPEEEC LALNSTWGCF CRQDLNSSDV HSLQPQLDCG PREIKVKVDK CLLGGLGLGE EVIAYLRDPN CSSILQTEER NWVSVTSPVQ ASACRNILER NQTHAIYKNT LSLVNDFIIR DTILNINFQC AYPLDMKVSL QAALQPIVSS LNVSVDGNGE FIVRMALFQD QNYTNPYEGD AVELSVESVL YVGAILEQGD TSRFNLVLRN CYATPTEDKA DLVKYFIIRN SCSNQRDSTI HVEENGQSSE SRFSVQMFMF AGHYDLVFLH CEIHLCDSLN EQCQPSCSRS QVRSEVPAID LARVLDLGPI TRRGAQSPGV MN
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Functions as an intestinal M-cells transcytotic receptor specific of type-I-piliated bacteria that participate in the mucosal immune response toward these bacteria. At the apical membrane of M-cells binds fimH, a protein of the bacteria type I pilus tip. Internalizes bound bacteria, like E.coli and S.typhimurium, from the lumen of the intestine and delivers them, through M-cells, to the underlying organized lymphoid follicles where they are captured by antigen-presenting dendritic cells to ellicit a mucosal immune response.
  • 基因功能参考文献：
    1. Data indicate the secretory granule membrane glycoprotein 2 as a marker for PDX1+/NKX6-1+ pancreatic progenitors (PPs). PMID: 28835709
    2. Totals of 12.4% and 20.8% of Crohn's disease patients were positive for IgA/IgG type of anti-GP2 and anti-CUZD1, respectively. Positivity for anti-pancreatic autoantibodies predicted a faster progression towards complicated disease course. PMID: 25968583
    3. Anti-GP2 antibody positive CD patients had higher ASCA titres compared to seronegative cases. PMID: 23118780
    4. A novel role for GP2 in immune regulation could provide a platform for new therapeutic interventions in the treatment of Crohn disease. PMID: 22891285
    5. GP2 is a binding partner of the scavenger receptor expressed on endothelial cells I (SREC-I) but not of SR-AI and SR-BI. Dendritic cells express SREC-I and also bind and internalize GP2. PMID: 21190681
    6. GP2 gene is unlikely to play a major role in the etiology of chronic pancreatitis. PMID: 20335779
    7. Data suggest that GP2 alterations do not alter the risk for the development of chronic pancreatitis. PMID: 19959969
    8. This study represents the first detailed analysis of any variation in the GP2 gene and gives some support to the putative association of c.1275A>G with chronic pancreatitis disease protection. PMID: 19919903
    9. GP2 binds to Type 1 fimbria, a bacterial adhesin that is commonly expressed by members of the Enterobacteriacae family. PMID: 19627615
    10. glycoprotein 2 (GP2), specifically expressed on the apical plasma membrane of M cells among enterocytes, serves as a transcytotic receptor for mucosal antigens PMID: 19907495
    11. According to human genome blasts for Build 35.1, this gene is located on 16p12 not 9q21 as described in this paper. PMID: 9605860

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  • 亚细胞定位：
    Zymogen granule membrane; Lipid-anchor, GPI-anchor. Secreted. Cell membrane; Lipid-anchor, GPI-anchor. Apical cell membrane; Lipid-anchor, GPI-anchor. Membrane raft; Lipid-anchor, GPI-anchor. Endosome.
  • 组织特异性：
    Expressed in pancreas (at protein level). Specifically expressed by M (microfold) cells which are atypical epithelial cells of the intestine (at protein level).
  • 数据库链接：

    HGNC: 4441

    OMIM: 602977

    KEGG: hsa:2813

    STRING: 9606.ENSP00000370767

    UniGene: Hs.53985