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  4. Recombinant Human Peptidyl-prolyl cis-trans isomerase B (PPIB)

Recombinant Human Peptidyl-prolyl cis-trans isomerase B (PPIB)

  • 货号：
    CSB-YP018472HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP018472HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP018472HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP018472HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP018472HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    PPIB
  • Uniprot No.：
  • 别名：
    AA408962; AA553318; AI844835; Cphn 2; Cphn2; Cyclophilin B; Cyclophilin like protein; CyP 20b; CYP S1; CYP-S1; CYPB; EC 5.2.1.8; MGC14109; MGC2224; OI9; peptidyl prolyl cis trans isomerase B; Peptidyl prolyl cis trans isomerase B precursor; Peptidyl-prolyl cis-trans isomerase B; peptidylprolyl isomerase B (cyclophilin B); Peptidylprolyl isomerase B; PPIase; PPIase B; Ppib; PPIB_HUMAN; Rotamase; Rotamase B; S cyclophilin; S-cyclophilin; SCYLP
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    34-216
  • 氨基酸序列
    DEKKKGP KVTVKVYFDL RIGDEDVGRV IFGLFGKTVP KTVDNFVALA TGEKGFGYKN SKFHRVIKDF MIQGGDFTRG DGTGGKSIYG ERFPDENFKL KHYGPGWVSM ANAGKDTNGS QFFITTVKTA WLDGKHVVFG KVLEGMEVVR KVESTKTDSR DKPLKDVIIA DCGKIEVEKP FAIAKE
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding.
  • 基因功能参考文献：
    1. A graphene-based nanocarrier modified with death receptor 4 (DR4) antibody and AKT siRNA has been developed, which can synergistically strengthen death receptor-mediated apoptosis and enhance the cancer therapeutic effect in vivo. PMID: 30430148
    2. Data show that Cyclophilin B is present on the erythrocytes and binds strongly to merozoites. PMID: 29146974
    3. cyclophilin B (CYPB) functions in protecting cells against aldosterone-induced oxidative stress, endoplasmic reticulum stress (ERS) and tubular cell injury via its peptidyl-prolyl cis-trans isomerase (PPIase) activity. PMID: 27732567
    4. PPIB mutations and their associated phenotypes PMID: 28242392
    5. observed changes in activity of six rER-resident PPIases, cyclophilin B (encoded by the PPIB gene), FKBP13 (FKBP2), FKBP19 (FKBP11), FKBP22 (FKBP14), FKBP23 (FKBP7), and FKBP65 (FKBP10), due to posttranslational modifications of proline residues in the substrate. PMID: 28385890
    6. The data suggest that overexpressed CypB protects neuronal cells from MPP+-induced dopaminergic neuronal cell death PMID: 27569281
    7. This study enhances our knowledge about the mutational pattern of the LEPRE1, CRTAP, and PPIB genes. LEPRE1 should be the first gene analyzed in mutation detection studies in patients with recessive OI. PMID: 26634552
    8. Over-expression of CypB enhances HIV infection by increasing nuclear import of viral DNA. PMID: 26774171
    9. Cyclophilin B has a high diagnostic value for stomach cancer and its downregulation can effectively inhibit the growth of stomach cancer cells. Thus, cyclophilin B may be a potential therapeutic target for stomach cancer treatment PMID: 26125731
    10. The extracellular portion of cyclophilin B probably plays an important role in human diseases associated with acute or chronic inflammation PMID: 24713575
    11. Findings demonstrate that CypB prevents hypoxia-induced cell death through modulation of ubiquitin-mediated CHOP protein degradation, suggesting that CypB may have an important role in the tight regulation of CHOP under hypoxia. PMID: 24270407
    12. These findings establish cyclophilin C as an ER cyclophilin, demonstrate the novel involvement of cyclophilins B and C in ER redox homeostasis PMID: 24990953
    13. Cyclophilin B is a novel MDM2 interacting partner. PMID: 24583282
    14. cyclophilin B (CypB) is a prolyl isomerase residing in the endoplasmic reticulum (ER), that provides an essential survival signal in glioblastoma multiforme cells through myc and mutant p53 PMID: 24272483
    15. An additional function of the rough endoplasmic reticulum protein complex prolyl 3-hydroxylase 1.cartilage-associated protein.cyclophilin B: the CXXXC motif reveals disulfide isomerase activity in vitro. PMID: 24043621
    16. Cyclophilin B activity regulated secretion and activity of ADAMTS13. PMID: 23144461
    17. CypB has an essential function in protecting hepatoma cells against oxidative stress through binding to CD147 and regulating the ERK pathway PMID: 22555451
    18. these findings suggest an unexpected role for cyclophilin B in attenuation of the responses of proinflammatory macrophages PMID: 22798670
    19. CypB interacts with these proteins and is involved in ribosome biogenesis and RNA transcription. PMID: 22426501
    20. Cyclophilin B is a candidate pancreatic cancer biomarker. PMID: 22484812
    21. CypB induced by hypoxia stimulates the survival of hepatocellular carcinoma via a positive feedback loop with HIF-1alpha. PMID: 21748762
    22. CAHL is a CsA associated helicase-like protein, which would form trimer complex with cyclophilin B and NS5B of HCV PMID: 21559518
    23. peptidylprolyl cis-trans isomerase B may be required to effectively fold the proline-rich regions of the C-terminal propeptide of procollagen PMID: 21282188
    24. cyclophilin isoform B is likely responsible for down-regulation of carrier expression by CsA and that it does so via its chaperone activity on NaDC1 (by direct interaction) rather than its rotamase activity. PMID: 21257749
    25. These results suggest that CypB plays a crucial role in the replication of Japanese encephalitis virus through an interaction with NS4A. PMID: 21281954
    26. Data indicate that CypB through its interaction with Na/K-beta1 might regulate maturation and trafficking of the pump through the secretory pathway. PMID: 21085665
    27. Results reveal the P-domain functions as a unique protein-protein interaction domain and implicate a peptidyl prolyl isomerase as a new element in the calnexin cycle. PMID: 20801878
    28. Cyclophilin B significantly modulate prolactin-induced function in breast cancer cells, ultimately resulting in enhanced levels of prolactin-responsive gene expression, cell growth, and migration. PMID: 20237142
    29. a regulatory mechanism in which cell type-specific expression of certain heparan sulfate sulfotransferases determines the specific binding of CyPB to target cells PMID: 19940140
    30. calcium signaling through CD147 receptor; induces neutrophil chemotaxis PMID: 11688976
    31. act in the context of t lymphocyte recruitment and function PMID: 11867726
    32. Different regions of CyPB are involved in peripheral blood T-lymphocyte activation and imply an important physiological function for peptidylprolyl isomerase activity. PMID: 11955071
    33. Inhibition of the PT-pore (ANT-1) via up-regulation of cyclophilin D plays a role in tumorigenesis PMID: 14729611
    34. Cyclophilin B plays a critical role in the activation of interferon regulatory factor-3. PMID: 15764595
    35. CYPB is a functional rfegulator of hepacivirus RNA polymerase. PMID: 15989969
    36. results strongly support the hypothesis that 3-O-sulfation of GlcNH2 residues could be a key modification that provides specialized HS structures for CyPB binding to responsive cells PMID: 17588944
    37. Altogether, our results support a model whereby CyPB induces integrin-mediated adhesion via interaction with a multimolecular unit formed by the association between CD147, CD98 and beta1 integrins. PMID: 18054915
    38. CypB is a new TRPV6 accessory protein with potential involvement in TRPV6 channel activation through its peptidyl-prolyl cis/trans isomerase activity PMID: 18445599
    39. the enhanced expression of CypB in malignant breast epithelium may contribute to the pathogenesis of this disease PMID: 19056847
    40. PPIB mutations cause severe osteogenesis imperfecta PMID: 19781681

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  • 相关疾病：
    Osteogenesis imperfecta 9 (OI9)
  • 亚细胞定位：
    Virion.
  • 蛋白家族：
    Cyclophilin-type PPIase family, PPIase B subfamily
  • 数据库链接：

    HGNC: 9255

    OMIM: 123841

    KEGG: hsa:5479

    STRING: 9606.ENSP00000300026

    UniGene: Hs.434937