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  4. Recombinant Human Peptidyl-prolyl cis-trans isomerase FKBP1B (FKBP1B)

Recombinant Human Peptidyl-prolyl cis-trans isomerase FKBP1B (FKBP1B)

  • 货号：
    CSB-YP008692HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP008692HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP008692HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP008692HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP008692HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    FKBP1B
  • Uniprot No.：
  • 别名：
    12.6 kDa FK506-binding protein; 12.6 kDa FKBP; Calstabin 2; FK506 binding protein 1 like; FK506 binding protein 12.6; FK506 binding protein 1B 12.6 kDa; FK506 binding protein 1B; FK506-binding protein 1B; FKB1B_HUMAN; FKBP 12.6; FKBP 1B; FKBP 1L; FKBP 9; FKBP-12.6; FKBP-1B; FKBP12.6; Fkbp1b; FKBP1L; FKBP9; h FKBP 12; h-FKBP-12; Immunophilin FKBP12.6; OTK 4; OTK4; Peptidyl prolyl cis trans isomerase 1B; Peptidyl prolyl cis trans isomerase; Peptidyl-prolyl cis-trans isomerase FKBP1B; PKBP 1L; PKBP1L; PPIase 1B; PPIase; PPIase FKBP1B; Rotamase 1B; Rotamase
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-108
  • 氨基酸序列
    GVEIETISP GDGRTFPKKG QTCVVHYTGM LQNGKKFDSS RDRNKPFKFR IGKQEVIKGF EEGAAQMSLG QRAKLTCTPD VAYGATGHPG VIPPNATLIF DVELLNLE
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Has the potential to contribute to the immunosuppressive and toxic effects of FK506 and rapamycin. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
  • 基因功能参考文献：
    1. Our FRET-based HTS detects RyR binding of accessory proteins calmodulin (CaM) or FKBP12.6...One compound increased FRET and inhibited RyR1, which was only significant at nM [Ca(2+)], and accentuated without CaM present. PMID: 27760856
    2. Total chemical synthesis, refolding, and crystallographic structure of fully active immunophilin calstabin 2 PMID: 27670942
    3. results suggest that both FKBP12.6 and FKBP12 play critical roles in regulating RyR2 function by facilitating the termination of SOICR. PMID: 27154203
    4. Sirolimus-FKBP12.6 impairs endothelial barrier function by activation of protein kinase C-alpha and downstream disruption of the p120-VE cadherin interaction in vascular endothelium. PMID: 23887639
    5. FKBP12.6-deficient mice with cardiac hypertrophy do not display exercise-induced arrhythmia and/or sudden cardiac death. PMID: 22087651
    6. analysis of the ryanodine receptor FK506-binding protein subunit PMID: 20404344
    7. Characterize the kinetics of FKBP12/12.6 binding to RyR2 in ventricular myocytes and effects on calcium signaling. PMID: 20431056
    8. localization of binding site to the NH2-terminal domain of the cardiac Ca2+ release channel PMID: 12446682
    9. Data show that VTSIP- and ARVD2-associated point mutations influence positively and negatively, respectively, the binding of RyR2 to its gating protein FKBP12.6. PMID: 12459180
    10. data demonstrate that defective regulation of ryanodine receptor 2 causes altered cellular phenotype via profound perturbations in intracellular calcium signaling and highlight a key modulatory role of FK506 binding protein 12.6 PMID: 12754204
    11. FKBP1B gene is involved in the genetic susceptibility to the AITDs development in the studied family. PMID: 15497458
    12. novel interaction site for FKBP12.6 may be present at the RyR2 C terminus, proximal to the channel pore, a sterically appropriate location that would enable this protein to play a central role in the modulation of this critical ion channel PMID: 15591045
    13. FKBP12.6 plays a critical role in Ca channel gating, the R2401H mutation can be expected to alter Ca-induced Ca release and E-C coupling resulting in CPVT. PMID: 15749201
    14. Enhancing calstabin binding to ryanodine receptors improves cardiac and skeletal muscle function in heart failure. PMID: 15972811
    15. the redox state of the RyR is intimately connected with FKBP binding affinity. PMID: 17200109
    16. Data show that K201 abolished spontaneous calcium release in cardiac myocytes, and that treating ventricular myocytes with FK506 to dissociate FKBP12.6 from ryanodine receptor RyR2 did not affect the suppression of spontaneous Ca2+ release by K201. PMID: 17313373
    17. Results describe abrupt changes in the expression of FKBP12.6, SERCA2a, PKA, and ECE on reperfusion against ischemia, which are responsible for the rapid occurrence of ventricular fibrillation, and their prevention by CPU86017. PMID: 17506935
    18. the loss of FKBP12.6 has no significant effect on the conduction and activation of RyR2 or the propensity for spontaneous Ca(2+) release and stress-induced ventricular arrhythmias PMID: 17921453
    19. The findings suggest that FKBP12.6 regulation of RyR2 is unlikely to be the primary defect in inherited arrhythmogenic cardiac disease. PMID: 19226252

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  • 亚细胞定位：
    Cytoplasm. Sarcoplasmic reticulum.
  • 蛋白家族：
    FKBP-type PPIase family, FKBP1 subfamily
  • 组织特异性：
    Detected in heart muscle (at protein level). Isoform 1 and isoform 2 are ubiquitous with highest levels in brain and thymus.
  • 数据库链接：

    HGNC: 3712

    OMIM: 600620

    KEGG: hsa:2281

    STRING: 9606.ENSP00000370373

    UniGene: Hs.709461