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  4. Recombinant Human Peroxisomal membrane protein PEX13 (PEX13), partial

Recombinant Human Peroxisomal membrane protein PEX13 (PEX13), partial

  • 中文名称：
    人PEX13重组蛋白
  • 货号：
    CSB-YP849799HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人PEX13重组蛋白
  • 货号：
    CSB-EP849799HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人PEX13重组蛋白
  • 货号：
    CSB-EP849799HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人PEX13重组蛋白
  • 货号：
    CSB-BP849799HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人PEX13重组蛋白
  • 货号：
    CSB-MP849799HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    PEX13
  • Uniprot No.：
  • 别名：
    2610008O20Rik; NALD; OTTMUSP00000005454; Peroxin 13; Peroxin-13; Peroxin13; Peroxisomal membrane protein PEX 13; Peroxisomal membrane protein PEX13; Peroxisome biogenesis factor 13; PEX 13; pex13; PEX13_HUMAN; RP23-188K3.1; ZWS
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Component of the peroxisomal translocation machinery with PEX14 and PEX17. Functions as a docking factor for the predominantly cytoplasmic PTS1 receptor (PAS10/PEX5). Involved in the import of PTS1 and PTS2 proteins.
  • 基因功能参考文献：
    1. Data suggest that soluble/cytosolic PEX5 interacts with PEX14/PEX13 complex, a model for the docking/translocation module (DTM) of the peroxisomal matrix protein translocon; PEX14/PEX13 complex appears to function in peroxisomal membrane as large cavity into which cytosolic PEX5 can enter to release its cargo. (PEX = peroxisomal biogenesis factor) PMID: 28765278
    2. our results demonstrate that PEX13 is required for selective autophagy, and suggest that dysregulation of PEX13-mediated mitophagy may contribute to ZSS pathogenesis. PMID: 27827795
    3. Results show PEX13 interacts with itself in peroxisomes in living cells and the import of PTS1 (peroxisomal targeting signal 1) proteins is specifically disrupted when homooligomerization of PEX13 is interrupted. PMID: 23716570
    4. Pex13p has a role in determining the peroxisomal localization of Pex14p PMID: 14715663
    5. analysis of PEX13 substitution of Ile326 by threonine in a patient with peroxisomal biogenesis disorder [case report] PMID: 16006427
    6. Zellweger syndrome caused by PEX13 deficiency: report of two novel mutations. PMID: 19449432

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  • 相关疾病：
    Peroxisome biogenesis disorder complementation group 13 (PBD-CG13); Peroxisome biogenesis disorder 11A (PBD11A); Peroxisome biogenesis disorder 11B (PBD11B)
  • 亚细胞定位：
    Peroxisome membrane; Single-pass membrane protein.
  • 蛋白家族：
    Peroxin-13 family
  • 数据库链接：

    HGNC: 8855

    OMIM: 601789

    KEGG: hsa:5194

    STRING: 9606.ENSP00000295030

    UniGene: Hs.161377