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  4. Recombinant Human Phosphatidylethanolamine-binding protein 4 (PEBP4)

Recombinant Human Phosphatidylethanolamine-binding protein 4 (PEBP4)

  • 中文名称：
    人PEBP4重组蛋白
  • 货号：
    CSB-YP857025HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人PEBP4重组蛋白
  • 货号：
    CSB-EP857025HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人PEBP4重组蛋白
  • 货号：
    CSB-EP857025HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人PEBP4重组蛋白
  • 货号：
    CSB-BP857025HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人PEBP4重组蛋白
  • 货号：
    CSB-MP857025HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    PEBP4
  • Uniprot No.：
  • 别名：
    PEBP4; CORK1; UNQ1933/PRO4408; Phosphatidylethanolamine-binding protein 4; PEBP-4; hPEBP4; Protein cousin-of-RKIP 1
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    23-227
  • 氨基酸序列
    DEDENSPC AHEALLDEDT LFCQGLEVFY PELGNIGCKV VPDCNNYRQK ITSWMEPIVK FPGAVDGATY ILVMVDPDAP SRAEPRQRFW RHWLVTDIKG ADLKKGKIQG QELSAYQAPS PPAHSGFHRY QFFVYLQEGK VISLLPKENK TRGSWKMDRF LNRFHLGEPE ASTQFMTQNY QDSPTLQAPR ERASEPKHKN QAEIAAC
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Promotes AKT phosphorylation, suggesting a possible role in the PI3K-AKT signaling pathway.
  • 基因功能参考文献：
    1. PEBP4 was associated with the development and invasion of gastric cancer cells through activation of the PI3K/Akt signaling pathway PMID: 28193908
    2. knockdown of PEBP4 inhibited hypoxia-induced epithelial-to-mesenchymal transition in prostate cancer cells. PMID: 27261570
    3. this study suggested that PEBP4 might promote the progression of pancreatic ductal adenocarcinoma PMID: 26311050
    4. Increased expression of phosphatidylethanolamine-binding protein 4 strongly associates with gliomas grade. PMID: 26725095
    5. PEBP4 is a secreted protein and has multiple functions, including a role in Akt phosphorylation. PMID: 27033522
    6. Increased miR-15b expression in lung adenocarcinoma patients treated with cisplatin-based chemotherapy was correlated with low expression of PEBP4, decreased sensitivity to cisplatin and poor prognosis. PMID: 25721211
    7. concluded that hPEBP4, specifically expressed in rectal cancer cells, is associated with radioresistance of rectal cancer PMID: 24594691
    8. overexpression of PEBP4, which we show to be a target of miR-34a, reduces the sensitivity of lung cancer cells to cisplatin PMID: 25038915
    9. in human breast cancer hPEBP4 is a novel and clinically relevant metastasis accelerator gene PMID: 24276246
    10. Human PEBP4 expression correlates negatively with estrogen and progesterone receptors in endometrial carcinoma. PMID: 23818363
    11. hPEBP4 knockdown potentiated the chemosensitization of the rituximab in B-cell lymphoma cells by regulating the expression of Bcl-xl, Cycline E, p21(waf/cip1) and p53 and the activation of caspase-3 and caspase-9. PMID: 23451095
    12. the independent predictive values of hPEBP4 in response of rectal cancer to preoperative radiotherapy, are reported. PMID: 22801881
    13. PEBP4 enhanced cell proliferation and invasion ability and inhibited apoptosis. Decreased PEBP4 expression may play a role in the reduced invasion ability and increased apoptosis of the human non-small cell lung cancer cell line HCC827. PMID: 22983920
    14. PEBP4 over-expression may promote the invasion and metastasis of non-small cell lung cancer. PMID: 22076923
    15. The over-expression of PEBP4 protein may be related to the tumorigenesis, development, metastasis, and invasion of colorectal cancer. PMID: 22125029
    16. Data show that PEBP4 protein overexpression was associated with the occurrence, invasion, and metastasis of lung squamous cell carcinoma. PMID: 21887552
    17. hPEBP4 inhibits proteasome-dependent ERalpha degradation through the Src pathway. PMID: 20460377
    18. hPEBP4 promotes cellular resistance to TNF-induced apoptosis by inhibiting activation of the Raf-1/MEK/ERK pathway, JNK, and PE externalization. PMID: 15302887
    19. Silencing of hPEBP4, an important potential target, may be a promising approach for the treatment of ovarian cancer. PMID: 16865237
    20. Data show that PEBP4 participates in the control of muscle cell differentiation by modulating the activity of MEK and ERK. PMID: 19197339

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Phosphatidylethanolamine-binding protein family
  • 数据库链接：

    HGNC: 28319

    OMIM: 612473

    KEGG: hsa:157310

    STRING: 9606.ENSP00000256404

    UniGene: Hs.491242