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  4. Recombinant Human Phosphatidylinositol transfer protein alpha isoform (PITPNA)

Recombinant Human Phosphatidylinositol transfer protein alpha isoform (PITPNA)

  • 中文名称：
    人PITPNA重组蛋白
  • 货号：
    CSB-YP018035HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人PITPNA重组蛋白
  • 货号：
    CSB-EP018035HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人PITPNA重组蛋白
  • 货号：
    CSB-EP018035HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人PITPNA重组蛋白
  • 货号：
    CSB-BP018035HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人PITPNA重组蛋白
  • 货号：
    CSB-MP018035HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    PITPNA
  • Uniprot No.：
  • 别名：
    MGC99649; Phosphatidylinositol transfer protein alpha; Phosphatidylinositol transfer protein alpha isoform; Phosphotidylinositol transfer protein; PI-TP-alpha; PIPNA_HUMAN; PITP alpha; Pitpna; PITPNB; PtdIns transfer protein alpha; PtdInsTP alpha; PtdInsTP; Vb; VIB1A; Vibrator
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-270
  • 氨基酸序列
    VLLKEYRVI LPVSVDEYQV GQLYSVAEAS KNETGGGEGV EVLVNEPYEK DGEKGQYTHK IYHLQSKVPT FVRMLAPEGA LNIHEKAWNA YPYCRTVITN EYMKEDFLIK IETWHKPDLG TQENVHKLEP EAWKHVEAVY IDIADRSQVL SKDYKAEEDP AKFKSIKTGR GPLGPNWKQE LVNQKDCPYM CAYKLVTVKF KWWGLQNKVE NFIHKQERRL FTNFHRQLFC WLDKWVDLTM DDIRRMEEET KRQLDEMRQK DPVKGMTADD
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Catalyzes the transfer of phosphatidylinositol (PI) and phosphatidylcholine (PC) between membranes. Shows a preference for PI and PC containing shorter saturated or monosaturated acyl chains at the sn-1 and sn-2 positions. Preference order for PC is C16:1 > C16:0 > C18:1 > C18:0 > C20:4 and for PI is C16:1 > C16:0 > C18:1 > C18:0 > C20:4 > C20:3.
  • 基因功能参考文献：
    1. Data show that phosphatidylinositol transfer protein alpha (PITPalpha) is involved in the function of mixed lineage kinase domain-like protein (MLKL) in necroptosis. PMID: 29104146
    2. the PITPalpha structure has to relax to allow access to the Ser166 site, and this may occur at the membrane surface where PI delivery is required for receptor-mediated PLC signaling PMID: 15322105
    3. the apparent occurrence of an unusual TG 3' splice site in intron 4 is discussed PMID: 17672918
  • 亚细胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    PtdIns transfer protein family, PI transfer class I subfamily
  • 数据库链接：

    HGNC: 9001

    OMIM: 600174

    KEGG: hsa:5306

    STRING: 9606.ENSP00000316809

    UniGene: Hs.429819