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  4. Recombinant Human Phosphatidylserine synthase 1 (PTDSS1), partial

Recombinant Human Phosphatidylserine synthase 1 (PTDSS1), partial

In Stock
  • 中文名称：
    人PTDSS1重组蛋白
  • 货号：
    CSB-RP043054h
  • 规格：
    ￥1344
  • 图片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

产品详情

  • 纯度：
    Greater than 90% as determined by SDS-PAGE.
  • 基因名：
    PTDSS1
  • Uniprot No.：
  • 别名：
    PTDSS1; KIAA0024; PSSA; Phosphatidylserine synthase 1; PSS-1; PtdSer synthase 1; EC 2.7.8.29; Serine-exchange enzyme I
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 来源：
    E.coli
  • 分子量：
    31.1kDa
  • 表达区域：
    1-35aa
  • 氨基酸序列
    MASCVGSRTLSKDDVNYKMHFRMINEQQVEDITID
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal GST-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Tris-based buffer,50% glycerol
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    3-7 business days
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) or phosphatidylcholine (PC) is replaced by L-serine. Catalyzes mainly the conversion of phosphatidylcholine. Also converts, in vitro and to a lesser extent, phosphatidylethanolamine.
  • 基因功能参考文献：
    1. RYR2, PTDSS1 and AREG are autism susceptibility genes that are implicated in a Lebanese population-based study of copy number variations in this disease. PMID: 26742492
    2. PSS1 mutations not only affect cellular PS levels and distribution but also lead to a more complex imbalance in lipid homeostasis by disturbing PI4P metabolism. PMID: 27044099
    3. Gain-of-function missense mutations in the phosphatidylserine synthase 1 (PTDSS1) gene cause Lenz-Majewski syndrome. PMID: 24241535
    4. Purification and characterization of human phosphatidylserine synthases 1 and 2. PMID: 19014349
  • 相关疾病：
    Lenz-Majewski hyperostotic dwarfism (LMHD)
  • 亚细胞定位：
    Endoplasmic reticulum membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Phosphatidyl serine synthase family
  • 数据库链接：

    HGNC: 9587

    OMIM: 151050

    KEGG: hsa:9791

    STRING: 9606.ENSP00000430548

    UniGene: Hs.292579