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  4. Recombinant Human Phosphoinositide-3-kinase-interacting protein 1 (PIK3IP1), partial

Recombinant Human Phosphoinositide-3-kinase-interacting protein 1 (PIK3IP1), partial

  • 中文名称：
    人PIK3IP1重组蛋白
  • 货号：
    CSB-YP850293HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人PIK3IP1重组蛋白
  • 货号：
    CSB-EP850293HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人PIK3IP1重组蛋白
  • 货号：
    CSB-EP850293HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人PIK3IP1重组蛋白
  • 货号：
    CSB-BP850293HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人PIK3IP1重组蛋白
  • 货号：
    CSB-MP850293HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    PIK3IP1
  • Uniprot No.：
  • 别名：
    HGFL; hHGFL(S); Kringle domain containing protein HGFL ; Kringle domain-containing protein HGFL; MGC17330; P3IP1_HUMAN; Phosphoinositide 3 kinase interacting protein 1; Phosphoinositide-3-kinase-interacting protein 1; PIK3IP1
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Negative regulator of hepatic phosphatidylinositol 3-kinase (PI3K) activity.
  • 基因功能参考文献：
    1. Findings indicate that colon cancer associated transcript 1 (non-protein coding) (CCAT1) was upregulated in osteosarcoma tissues and cells, and was involved in the proliferation and migration of osteosarcoma via regulating miR-148a/phosphatidyl inositol 3-kinase interacting protein 1 (PIK3IP1) signal pathway. PMID: 28549102
    2. These results suggest that the novel PI3K regulator PIK3IP1 plays an inhibitory role in T-cell activation. PMID: 22706993
    3. PIK3IP1-v1 is a novel splicing isoform of PIK3IP1. Both of them are located on cell membrane and can induce cell apoptosis. PMID: 19088825
    4. PIK3IP1 directly binds to the p110 catalytic subunit and down modulates PI3K activity. Suggested that PIK3IP1 is a new type of PI3K regulator. PMID: 17475214
    5. PIK3IP1 is an important regulator of PI3K in vivo, and its dysregulation can contribute to liver carcinogenesis PMID: 18632611

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  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein.
  • 数据库链接：

    HGNC: 24942

    KEGG: hsa:113791

    STRING: 9606.ENSP00000215912

    UniGene: Hs.26670