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  4. Recombinant Human Plasmalemma vesicle-associated protein (PLVAP), partial

Recombinant Human Plasmalemma vesicle-associated protein (PLVAP), partial

  • 货号：
    CSB-YP871596HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP871596HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP871596HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP871596HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP871596HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    PLVAP
  • Uniprot No.：
  • 别名：
    FELS; Fenestrated endothelial linked structure protein; Fenestrated endothelial-linked structure protein; gp68; Hypothetical protein DKFZp667O074; Meca 32 antigen; MECA32 antigen; Panendothelial cell antigen; Plasmalemma vesicle associated protein; Plasmalemma vesicle protein 1; Plasmalemma vesicle-associated protein; Plvap; PLVAP_HUMAN; PV 1; PV-1; PV1; PV1 protein
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Endothelial cell-specific membrane protein involved in the formation of the diaphragms that bridge endothelial fenestrae. It is also required for the formation of stomata of caveolae and transendothelial channels. Functions in microvascular permeability, endothelial fenestrae contributing to the passage of water and solutes and regulating transcellular versus paracellular flow in different organs. Plays a specific role in embryonic development.
  • 基因功能参考文献：
    1. PV-1 transcription was markedly induced in diabetic retina and by VEGF in retinal endothelial cells PMID: 19284967
    2. Expression of plasmalemma vesicle-associated protein (PLVAP) is increased in endothelial cells in the presence of VEGF PMID: 22200486
    3. In Kimba and Akimba mice fluorescein leakage was associated with focal angiogenesis and correlated significantly with Plvap gene expression. PMID: 24703908
    4. Plasmalemma vesicle-associated protein has a role in vascular permeability PMID: 26878208
    5. The molecule recognized by PAL-E and anti-PV-1 antibodies is not NRP-1 but PV-1. PMID: 22627768
    6. These results suggest that PV1 protein is able to block SV40 infectivity at low but not at high viral concentration either by interfering with the infective internalization pathway at the cell surface or at a post internalization step. PMID: 21827737
    7. Case Report: Suggest activated platelets, enhanced coagulation state, glomerular expression of PV-1 and endothelial damage may contribute to glomerulonephropathy associated with polycythemia vera. PMID: 20979949
    8. PV1 is a key structural component, necessary for the biogenesis of the stomatal and fenestral diaphragms. PMID: 15155804
    9. Plasmalemmal vesicle associated protein-1 has a role in brain tumor angiogenesis PMID: 16278383
    10. leukocyte transendothelial migration is the first known function for PV-1 PMID: 19420356

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  • 亚细胞定位：
    Cell membrane; Single-pass type II membrane protein. Membrane, caveola; Single-pass type II membrane protein. Cytoplasm, perinuclear region.
  • 组织特异性：
    Expressed in lung, kidney, heart, aorta, placenta, muscle, pituitary gland, adrenals, mammary gland, bladder, lymph node, bone marrow, trachea, digestive tract, liver and tumor-associated endothelium.
  • 数据库链接：

    HGNC: 13635

    OMIM: 607647

    KEGG: hsa:83483

    STRING: 9606.ENSP00000252590

    UniGene: Hs.107125