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  4. Recombinant Human Plastin-3 (PLS3)

Recombinant Human Plastin-3 (PLS3)

  • 货号：
    CSB-YP018206HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP018206HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP018206HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP018206HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP018206HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    PLS3
  • Uniprot No.：
  • 别名：
    BMND18; Plastin 3 (T isoform); Plastin 3; Plastin-3; PLS3; PLST_HUMAN; T fimbrin; T-plastin
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-630
  • 氨基酸序列
    MDEMATTQIS KDELDELKEA FAKVDLNSNG FICDYELHEL FKEANMPLPG YKVREIIQKL MLDGDRNKDG KISFDEFVYI FQEVKSSDIA KTFRKAINRK EGICALGGTS ELSSEGTQHS YSEEEKYAFV NWINKALEND PDCRHVIPMN PNTDDLFKAV GDGIVLCKMI NLSVPDTIDE RAINKKKLTP FIIQENLNLA LNSASAIGCH VVNIGAEDLR AGKPHLVLGL LWQIIKIGLF ADIELSRNEA LAALLRDGET LEELMKLSPE ELLLRWANFH LENSGWQKIN NFSADIKDSK AYFHLLNQIA PKGQKEGEPR IDINMSGFNE TDDLKRAESM LQQADKLGCR QFVTPADVVS GNPKLNLAFV ANLFNKYPAL TKPENQDIDW TLLEGETREE RTFRNWMNSL GVNPHVNHLY ADLQDALVIL QLYERIKVPV DWSKVNKPPY PKLGANMKKL ENCNYAVELG KHPAKFSLVG IGGQDLNDGN QTLTLALVWQ LMRRYTLNVL EDLGDGQKAN DDIIVNWVNR TLSEAGKSTS IQSFKDKTIS SSLAVVDLID AIQPGCINYD LVKSGNLTED DKHNNAKYAV SMARRIGARV YALPEDLVEV KPKMVMTVFA CLMGRGMKRV
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Actin-bundling protein found in intestinal microvilli, hair cell stereocilia, and fibroblast filopodia. May play a role in the regulation of bone development.
  • 基因功能参考文献：
    1. PLS3 deletions lead to severe childhood-onset osteoporosis resulting from defective bone matrix mineralization. PMID: 28777485
    2. PLS3 sequencing in childhood-onset primary osteoporosis identifies two novel disease-causing variants. PMID: 28748388
    3. T-plastin mediates the hypoxia-induced membrane trafficking PMID: 28218996
    4. PLS3 mutation plays a role in low turnover osteoporosis pathophysiology. PMID: 28379384
    5. Patients with PLS3 mutation-related osteoporosis respond to teriparatide treatment. PMID: 27732335
    6. We show that genes of the classical apoptosis pathway are involved in the smn-1-mediated neuronal death, and that this phenotype can be rescued by the expression of human SMN1, indicating a functional conservation between the two orthologs. Finally, we determined that Plastin3/plst-1 genetically interacts with smn-1 to prevent degeneration, and that treatment with valproic acid is able to rescue the degenerative phenotype PMID: 27260405
    7. PLS3 expression does not always modify SMA phenotype PMID: 27279027
    8. findings emphasize the power of genetic modifiers, PLS3 and CORO1C, to unravel the cellular pathomechanisms underlying spinal muscular atrophy (SMA)--and the power of combinatorial therapy based on splice correction of SMN2 and endocytosis improvement to efficiently treat SMA PMID: 27499521
    9. t is beyond doubt that PL S3 must be further investigated to determine its role in diagnostics, prediction, treatment and monitoring of treatment of colorectal cancer. PMID: 26146096
    10. PLS3 is a genuine spinal muscular atrophy protective modifier in SMN1-deleted individuals PMID: 26573968
    11. Measurements of SMN and PLS3 transcript and protein levels in induced pluripotent stem cell-derived motor neurons show limited value as Spinal muscular atrophy biomarkers. PMID: 26114395
    12. High levels of recombinant hPLS3 mRNA were expressed in motor neurons of SMA mice and an increased level of PLS3 protein in total spinal cord, yet neither survival nor the fundamental electrophysiological aspects of the neuromuscular junction improved. PMID: 26134627
    13. results confirm the role of PLS3 mutations in early onset osteoporosis. The mechanism whereby PLS3 affects bone health is unclear, but it may be linked to osteocyte dendrite function and skeletal mechanosensing PMID: 25209159
    14. plastin 3 is a regulator of actin microfilament bundles at the ES in which it dictates the configuration of the filamentous actin network PMID: 26048141
    15. PLS3 was expressed in circulating tumor cells undergoing the epithelial-mesenchymal transition in patients with breast cancer; an excellent biomarker for identifying groups at risk of recurrence or with a poor prognosis PMID: 25880010
    16. PLS3 overexpression is associated with colorectal cancer. PMID: 24217791
    17. T-plastin expression downstream to the calcineurin/NFAT pathway is involved in keratinocyte migration. PMID: 25226517
    18. Data suggest that several single-nucleotide polymorphisms (SNPs) of the plastin genes PLS3 and LCP1 could serve as gender- and/or stage-specific molecular predictors of tumor recurrence in stage II/III colorectal cancer as well as therapeutic targets. PMID: 24170770
    19. Loss of PLS3 is associated with spinal muscular atrophy. PMID: 24271012
    20. PLS3 expression and SMA phenotype: a commentary on correlation of PLS3 expression with disease severity in children with spinal muscular atrophy. PMID: 24284364
    21. PLS3 gene may have an age- and gender-specific role in the clinical severity of SMA in children afflicted with this condition. PMID: 24172247
    22. Plastin 3 (PLS3) appears to be important in human bone health, on the basis of pathogenic variants in PLS3 in five families with X-linked osteoporosis and osteoporotic fractures that we report here. PMID: 24088043
    23. study identified a common gene variant in PLS3 as an independent prognostic marker in female patients with stage II and III colon cancer PMID: 23549633
    24. PLS3 over-expression led to a stabilization of axons which, in turn, results in a significant delay of axon pruning, counteracting poor axonal connectivity in spinal muscular atrophy neuromuscular junctions. PMID: 23263861
    25. Overexpression of PLS3 is associated with epithelial-mesenchymal transition and is associated with metastasis in colorectal cancer PMID: 23378342
    26. PLS3, Twist, KIR3DL2 and NKp46 gene expression can model efficient molecular Sezary syndrome diagnosis. PMID: 23429988
    27. PLS3 is expressed in the majority of SS patients and provide insight into the molecular regulation of PLS3 expression in CTCL PMID: 22495182
    28. T-plastin is a marker restricted to malignant lymphocytes from Sezary syndrome patients and plays a role for cell survival and migration. PMID: 22627769
    29. The PLS3 gene may be an age- and/or puberty-specific and sex-specific modifier of spinal muscular atrophy. PMID: 20937953
    30. expression of T-plastin in the placental context may indeed be associated with the enhanced replicative potential of placental trophoblasts. PMID: 14567899
    31. T-plastin has the potential to be a Sezary cell-specific marker valuable for diagnostic and treatment of Sezary syndrome. PMID: 14612505
    32. T-plastin increases Arp2/3-mediated actin-based movement PMID: 15741236
    33. T-fimbrin has a role in the response to DNA damage PMID: 16142308
    34. unaffected SMN1-deleted females exhibit significantly higher expression of PLS3 than their spinal muscular atrophy-affected counterparts PMID: 18440926
    35. Increased T-plastin is associated with leukemic cutaneous T-cell lymphoma PMID: 18569641

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  • 相关疾病：
    Osteoporosis (OSTEOP)
  • 亚细胞定位：
    Cytoplasm.
  • 组织特异性：
    Expressed in a variety of organs, including muscle, brain, uterus and esophagus.
  • 数据库链接：

    HGNC: 9091

    OMIM: 166710

    KEGG: hsa:5358

    STRING: 9606.ENSP00000348163

    UniGene: Hs.496622