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  4. Recombinant Human Pleckstrin homology domain-containing family A member 8 (PLEKHA8)

Recombinant Human Pleckstrin homology domain-containing family A member 8 (PLEKHA8)

  • 中文名称：
    人PLEKHA8重组蛋白
  • 货号：
    CSB-YP856957HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人PLEKHA8重组蛋白
  • 货号：
    CSB-EP856957HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人PLEKHA8重组蛋白
  • 货号：
    CSB-EP856957HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人PLEKHA8重组蛋白
  • 货号：
    CSB-BP856957HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人PLEKHA8重组蛋白
  • 货号：
    CSB-MP856957HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    PLEKHA8
  • Uniprot No.：
  • 别名：
    FAPP-2; FAPP2; hFAPP2; MGC3358; PH domain-containing family A member 8; Phosphatidylinositol-four-phosphate adapter protein 2; Phosphoinositide binding specificmember 8 ; Phosphoinositol 4 phosphate adaptor protein 2; Phosphoinositol 4-phosphate adapter protein 2; PKHA8_HUMAN; Pleckstrin homology domain containing A8; Pleckstrin homology domain containing family A (Phosphoinositide binding specific) member 8; Pleckstrin homology domain containing family A; Pleckstrin homology domain-containing family A member 8; Plekha8; PLEKHA8 protein ; Serologically defined breast cancer antigen NY-BR-86
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-519
  • 氨基酸序列
    MEGVLYKWTN YLSGWQPRWF LLCGGILSYY DSPEDAWKGC KGSIQMAVCE IQVHSVDNTR MDLIIPGEQY FYLKARSVAE RQRWLVALGS AKACLTDSRT QKEKEFAENT ENLKTKMSEL RLYCDLLVQQ VDKTKEVTTT GVSNSEEGID VGTLLKSTCN TFLKTLEECM QIANAAFTSE LLYRTPPGSP QLAMLKSSKM KHPIIPIHNS LERQMELSTC ENGSLNMEIN GEEEILMKNK NSLYLKSAEI DCSISSEENT DDNITVQGEI RKEDGMENLK NHDNNLTQSG SDSSCSPECL WEEGKEVIPT FFSTMNTSFS DIELLEDSGI PTEAFLASCY AVVPVLDKLG PTVFAPVKMD LVGNIKKVNQ KYITNKEEFT TLQKIVLHEV EADVAQVRNS ATEALLWLKR GLKFLKGFLT EVKNGEKDIQ TALNNAYGKT LRQHHGWVVR GVFALALRAA PSYEDFVAAL TVKEGDHQKE AFSIGMQRDL SLYLPAMEKQ LAILDTLYEV HGLESDEVV
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Cargo transport protein that is required for apical transport from the Golgi complex. Transports AQP2 from the trans-Golgi network (TGN) to sites of AQP2 phosphorylation. Mediates the non-vesicular transport of glucosylceramide (GlcCer) from the trans-Golgi network (TGN) to the plasma membrane and plays a pivotal role in the synthesis of complex glycosphingolipids. Binding of both phosphatidylinositol 4-phosphate (PIP) and ARF1 are essential for the GlcCer transfer ability. Also required for primary cilium formation, possibly by being involved in the transport of raft lipids to the apical membrane, and for membrane tubulation.
  • 基因功能参考文献：
    1. Altogether, this study implies that hepatitis C virus coopts FAPP2 for virus genome replication via phosphatidylinositol 4-phosphate binding and glycosphingolipid transport to the hepatitis C virus replication complex. PMID: 25122779
    2. FAPP2 functions in both membrane trafficking and lipid metabolism in a fashion that integrates its activities in membrane trafficking and in lipid transfer. (Review) PMID: 22266015
    3. Data demonstrate FAPP2 is required for cilium formation in polarized MDCK cells. PMID: 17116893
    4. Data show that FAPP2 is present in tubules forming from the trans-Golgi in epithelial MDCK cells. PMID: 19940249
    5. FAPP2 plays a specific role in apical transport in MDCK cells. PMID: 16103222
    6. by coupling the synthesis of glycosphingolipids with their export to the cell surface, FAPP2 emerges as crucial in determining the lipid identity and composition of the plasma membrane PMID: 17687330
    7. These data demonstrate a previously unknown role for FAPP2 in conferring resistance to apoptosis and indicate that FAPP2 may be a target for cancer therapy. PMID: 19341712

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  • 亚细胞定位：
    Golgi apparatus, trans-Golgi network membrane. Membrane; Peripheral membrane protein.
  • 组织特异性：
    Expressed in kidney cell lines.
  • 数据库链接：

    HGNC: 30037

    OMIM: 608639

    KEGG: hsa:84725

    STRING: 9606.ENSP00000397947

    UniGene: Hs.233495